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  • دکتری (1391)

    فیزیولوژی پزشکی

    دانشگاه تربیت مدرس، تهران، ایران

  • دکتری (1387)

    پزشکی

    دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران

  • تنفس و عملکرد مغز
  • علوم اعصاب محاسباتی
  • سیستم های پیچیده در پزشکی
  • آزمایشگاه تنفس و فعالیت مغز

    زمینه های پژوهشی:

    کارشناس مسئول: مهدی سلیمی

    تلفن:

    مکان: ساختمان جدید طبقه ششم اتاق 608و609

داده ای یافت نشد

An optimized animal model of lysolecithin induced demyelination in optic nerve; more feasible, more reproducible, promising for studying the progressive forms of multiple sclerosis

Samaneh Dehghan, Ehsan Aref, Mohammad Reza Raoufy, Mohammad Javan
Journal PapersJournal of Neuroscience Methods , Volume 352 , 2021 March 15, {Pages 109088 }

Abstract

BackgroundMultiple Sclerosis (MS) is a demyelinating disease leading to long-term neurological deficit due to unsuccessful remyelination and axonal loss. Currently, there are no satisfactory treatments for progressive MS somewhat due to the lack of an adequate animal model for studying the mechanisms of disease progression and screening new drugs.New methodLysolecithin (LPC) or agarose-gel loaded LPC (AL-LPC) were applied to mouse optic nerve behind the globe via a minor surgery. Agarose loading was used to achieve longer time of LPC exposure and subsequently long-lasting demyelination.ResultsThe lesion sites characterized by luxol fast blue (LFB), FluoroMyelin, Bielschowsky’s staining, and immunostaining showed extensive demyelination an

Rhythmic air-puff into nasal cavity modulates activity across multiple brain areas: A non-invasive brain stimulation method to reduce ventilator-induced memory impairment

Sepideh Ghazvineh, Morteza Salimi, Milad Nazari, Mani Garousi, Farhad Tabasi, Kolsoum Dehdar, Alireza Salimi, Hamidreza Jamaati, Javad Mirnajafi-Zadeh, Ehsan Arabzadeh, Mohammad Reza Raoufy
Journal PapersRespiratory Physiology & Neurobiology , Volume 287 , 2021 May 1, {Pages 103627 }

Abstract

Mechanical ventilation (MV) can result in long-term brain impairments that are resistant to treatment. The mechanisms underlying MV-induced brain function impairment remain unclear. Since nasal airflow modulates brain activity, here we evaluated whether reinstating airflow during MV could influence the memory performance of rats after recovery. Rats were allocated into two study groups: one group received rhythmic air-puff into the nasal cavity during MV and a control group that underwent ventilation without air-puff. During MV, air-puffs induced time-locked event potentials in OB, mPFC and vHPC and significantly increased the oscillatory activity at the air-puff frequency. Furthermore, in mPFC and vHPC, (but not in OB), delta and theta osc

Allergic rhinitis impairs working memory in association with drop of hippocampal–prefrontal coupling

Morteza Salimi, Sepideh Ghazvineh, Milad Nazari, Kolsoum Dehdar, Mani Garousi, Meysam Zare, Farhad Tabasi, Hamidreza Jamaati, Alireza Salimi, Victoria Barkley, Javad Mirnajafi-Zadeh, Mohammad Reza Raoufy
Journal PapersBrain Research , 2021 February 11, {Pages 147368 }

Abstract

Allergic rhinitis (AR) is a chronic inflammatory disease frequently associated with a deficit in learning and memory. Working memory is an important system for decision making and guidance, which depends on interactions between the ventral hippocampus (vHipp) and the prelimbic prefrontal cortex (plPFC). It is still unclear whether AR influences the activity and coupling of these brain areas, which consequently may impair working memory. The current study aimed to examine alterations of the vHipp-plPFC circuit in a rat model of AR. Our results show decreased working memory performance in AR animals, accompanied by a reduction of theta and gamma oscillations in plPFC. Also, AR reduces coherence between vHipp and plPFC in both theta and gamma

The trend of disruption in the functional brain network topology of Alzheimer’s disease

Alireza Fathian, Yousef Jamali, Mohammad Reza Raoufy
Journal Papers , 2021 April 21, {Pages }

Abstract

Alzheimer’s disease (AD) is a progressive disorder associated with cognitive dysfunction that alters the brain’s functional connectivity. Assessing these alterations has become a topic of increasing interest. However, a few studies have examined different stages of AD from a complex network perspective that cover different topological scales. This study analyzed the trend of functional connectivity alterations from a cognitively normal (CN) state through early and late mild cognitive impairment (EMCI and LMCI) and to Alzheimer’s disease. The analyses had been done at the local (hubs and activated links and areas), meso (clustering, assortativity, and rich-club), and global (small-world, small-worldness, and efficiency) topological sca

The olfactory bulb modulates entorhinal cortex oscillations during spatial working memory

M Salimi, F Tabasi, M Nazari, S Ghazvineh, A Salimi, H Jamaati, ...
Journal Papers , , {Pages }

Abstract

Group I metabotropic glutamate receptors contribute to the antiepileptic effect of electrical stimulation in hippocampal CA1 pyramidal neurons

Z Ghasemi, N Naderi, A Shojaei, MR Raoufy, N Ahmadirad, V Barkley, ...
Journal Papers , , {Pages }

Abstract

Paternal preconception exposure to chronic morphine alters respiratory pattern in response to morphine in male offspring

M Azadi, E Aref, S Pazhoohan, MR Raoufy, S Semnanian, H Azizi
Journal Papers , , {Pages }

Abstract

Alpha adrenergic receptors have role in the inhibitory effect of electrical low frequency stimulation on epileptiform activity in rats

M Rezaei, N Ahmadirad, Z Ghasemi, A Shojaei, MR Raoufy, V Barkley, ...
Journal Papers , , {Pages }

Abstract

Online analysis of local field potentials for seizure detection in freely moving rats

Meysam Zare, Milad Nazari, Amir Shojaei, Mohammad Reza Raoufy, Javad Mirnajafi-Zadeh
Journal PapersIranian Journal of Basic Medical Sciences , Volume 23 , Issue 2, 2020 February 1, {Pages 173-177 }

Abstract

Objective (s): Seizure detection during online recording of electrophysiological parameters is very important in epileptic patients. In the present study, online analysis of field potential recordings was used for detecting spontaneous seizures in epileptic animals.Materials and Methods: Epilepsy was induced in rats by pilocarpine injection. During the chronic period of the pilocarpine model, local field potential (LFP) recording was run for at least 24 hr. At the same time, video monitoring of the animals was done to determine the real time of seizure occurrence. Both power and sample entropy of LFP were used for online analysis.Results: Obtained results showed that changes in LFP power are a better index for seizure detection. In addition

The role of dopamine D2-like receptors in a “depotentiation-like effect” of deep brain stimulation in kindled rats

Azam Sadeghian, Zahra Salari, Hossein Azizi, Mohammad Reza Raoufy, Amir Shojaei, Nastaran Kosarmadar, Meysam Zare, Mahmoud Rezaei, Victoria Barkley, Mohammad Javad, Yaghoub Fathollahi, Javad Mirnajafi-Zadeh
Journal PapersBrain Research , 2020 April 3, {Pages 146820 }

Abstract

The mechanisms involved in the anti-seizure effects of low-frequency stimulation (LFS) have not been completely determined. However, Gi-protein-coupled receptors, including D2-like receptors, may have a role in mediating these effects. In the present study, the role of D2-like receptors in LFS’ anti-seizure action was investigated. Rats were kindled with semi-rapid (6 stimulations per day), electrical stimulation of the hippocampal CA1 area. In LFS-treated groups, subjects received four trials of LFS at 5 min, 6 h, 24 h, and 30 h following the last kindling stimulation. Each LFS set occurred at 5 minute intervals, and consisted of 4 trains. Each train contained 200, 0/1 ms long, monophasic square wave pulses at 1 Hz. Haloperidol (D2-like

Cardiac function and tolerance to ischemia/reperfusion injury in a rat model of polycystic ovary syndrome during the postmenopausal period

Mahsa Noroozzadeh, Mohammad Reza Raoufy, Razieh Bidhendi Yarandi, Farzaneh Faraji Shahrivar, Naghmeh Moghimi, Fahimeh Ramezani Tehrani
Journal PapersLife Sciences , Volume 262 , 2020 December 1, {Pages 118394 }

Abstract

AimsThere is much controversy regarding whether cardiovascular events increase in women with polycystic ovary syndrome (PCOS) with aging. Considering the lack of possibility of certain investigations in humans, animal models of PCOS may be suitable resources to obtain the useful data needed. In this study; we aimed to investigate whether cardiac function and tolerance to ischemia/reperfusion (I/R) injury worsen in postmenopausal rats, who had PCOS at younger ages, compared to controls.Main methodsThe hearts of aged rats with a history of PCOS and their controls were isolated and perfused in a Langendorff apparatus. Values of hemodynamic parameters, including left ventricular systolic pressure (LVSP), left ventricular developed pressure (LVD

Inhibition of Rho-kinase improves response to deep inspiration in ovalbumin-sensitized guinea pigs

Saeed Pazhoohan, Ehsan Aref, Leila Zare, Samaneh Dehghan, Mohammad Javan, Sohrab Hajizadeh, Mohammad Reza Raoufy
Journal PapersIranian Journal of Basic Medical Sciences , Volume 23 , Issue 12, 2020 December , {Pages 1584 }

Abstract

Objective (s):The modulatory effect of deep inspiration (DI) on airway constriction is impaired in asthma. However, mechanisms underlying this impairment are not clear. Since there is evidence indicating that Rho-kinase activation mediates force maintenance under oscillatory strain, we investigated the impact of Rho-kinase inhibition on the bronchodilatory effect of DI in ovalbumin (OVA) sensitized guinea pigs.Materials and Methods:forty-eight male Dunkin Hartley guinea pigs were divided into 8 groups including saline/constant, saline/DI, OVA/constant, OVA/DI, Rho-I/OVA/constant, Rho-I/OVA/DI, OVA-Rho-I/MCh/constant, and OVA-Rho-I/MCh/DI. Animals were subjected to 12 inhalations of OVA or saline aerosol. Guinea pigs in Rho-I/OVA/constant or

Premature Ventricular Contraction (PVC) Detection System Based on Tunable Q-Factor Wavelet Transform

MH Mazidi, M Eshghi, MR Raoufy
Journal PapersJournal of Biomedical Physics and Engineering , 2020 December 30, {Pages }

Abstract

Background: The Electrocardiogram (ECG) is an important measure for diagnosing the presence or absence of heart arrhythmias. Premature ventricular contractions (PVC) is a relatively large arrhythmia occurring outside the normal tract and being triggered outside the Sino atrial (SA) node of heart. Objective: This study has focused on tunable Q-factor wavelet transform (TQWT) algorithm and statistical methods to detect PVC.Material and Methods: In this analytical and statistical study, 22 ECGs records were selected from the MIT/BIH arrhythmia database. In the first stage the noise of signal remove and then five sub-bands create by TQWT. In the second stage nine features (minimum, maximum, root mean square, mean, interquartile range, standard

Clinical Features and Outcomes of ICU Patients with COVID-19 Infection in Tehran, Iran: a Single-Centered Retrospective Cohort Study

Arshia Vahedi, Farhad Tabasi, Fateme Monjazebi, Seyed Mohammad Reza Hashemian, Payam Tabarsi, Behrooz Farzanegan, Majid Malekmohammad, Alireza Salimi, Morteza Salimi, Mohammad Reza Raoufy, Hamidreza Jamaati, Ali Akbar Velayati
Journal PapersTanaffos , Volume 19 , Issue 4, 2020 December , {Pages 300 }

Abstract

Background:The clinical characteristics of the novel coronavirus disease (COVID-19) were diverse and unspecific. Here, we identified the associated factors with surviving of COVID-19 ICU patients based on the clinical characteristics of patients admitted to one of the Corona Centre Hospitals of Iran.Materials and Methods:This cohort study was performed retrospectively from February to June 2020 on 133 COVID-19 patients admitted to 4 intensive care units of Masih Daneshvari Hospital in Tehran, Iran. Demographic, medical, clinical manifestation at admission, laboratory parameters and outcome data were obtained from medical records. Also the SOFA and APACHE II scores were calculated. All data were analyzed using SPSS (version 23, IBM Corp.) so

The effects of prenatal androgen exposure on cardiac function and tolerance to ischemia/reperfusion injury in male and female rats during adulthood

Mahsa Noroozzadeh, Mohammad Reza Raoufy, Razieh Bidhendi Yarandi, Farzaneh Faraji Shahrivar, Fahimeh Ramezani Tehrani
Journal PapersLife sciences , Volume 229 , 2019 July 15, {Pages 251-260 }

Abstract

AimsCardiovascular diseases may originate from suboptimal intrauterine environments. We aimed to examine the effects of prenatal androgen exposure (PAE) on heart basal hemodynamic parameters and tolerance to ischemia/reperfusion (I/R) injury, in PAE adult females and males.Main methodsPregnant Wistar rats in the experimental group (n = 8) received 5 mg of testosterone (s.c. injection) on the 20th day of pregnancy, while controls received solvent. The hearts of adult female and male offspring were isolated and perfused in a Langendorff apparatus, values of left ventricular systolic pressure(LVSP), left ventricular developed pressure(LVDP), rate pressure product(RPP) and peak rates of positive and negative changes in left ventricular pr

Modulating proteoglycan receptor PTPσ using intracellular sigma peptide improves remyelination and functional recovery in mice with demyelinated optic chiasm

Parvin Niknam, Mohammad Reza Raoufy, Yaghoub Fatholahi, Mohammad Javan
Journal PapersMolecular and Cellular Neuroscience , 2019 July 2, {Pages 103391 }

Abstract

Multiple sclerosis (MS) is an autoimmune disease characterized by myelin and axonal damage in the central nervous system (CNS). Glial scar which is a hallmark of MS contains repair inhibitory molecules including chondroitin sulfate proteoglycans (CSPGs). CSPGs inhibit repair of damaged area through various receptors including protein tyrosine phosphatase sigma (PTPσ). In the current study we use intracellular sigma peptide (ISP), an inhibitor of PTPσ signaling, in LPC-induced focal demyelination of mouse optic chiasm. ISP treatment resulted in decreased demyelination, reduced astrogliosis, and increased newly generated oligodendrocytes which subsequently led to enhanced remyelination. Analyzing of electrophysiological (as performed by vis

Brain wave disturbance and cognitive impairment after CPR

Yahya Jand, Mohammad Reza Raoufy, Ahmad Reza Dehpour
Journal PapersMedical hypotheses , Volume 126 , 2019 May 1, {Pages 129-130 }

Abstract

Cognitive impairment (CI) is a common morbidity after cardio-pulmonary resuscitation (CPR) with long time persistence. Brain hypoxia is believed to be the main but not the single etiology of post CPR cognitive impairment. Theta and lower theta waves of the EEG have essential role in proper functioning of the memory performance. Both endotracheal intubation and atropine administration in CPR process can abolish these waves. We hypothesize that CI in CPR survivors can be caused by disturbance in aforementioned waves due to endotracheal intubation and atropine administration.

Protective effect of heart rate variability biofeedback on stress-induced lung function impairment in asthma

Niloofar Taghizadeh, Alireza Eslaminejad, Mohammad Reza Raoufy
Journal PapersRespiratory physiology & neurobiology , Volume 262 , 2019 April 1, {Pages 49-56 }

Abstract

Psychological stress can provoke airway constriction in asthmatic patients, which may be because of autonomic nervous system dysfunction in asthma. We investigated the effect of enhancing respiratory sinus arrhythmia using heart rate variability biofeedback (HRV-BF) on spirometry performance and HRV indices during stress induced by Stroop Color-Word interference test in asthmatic patients and healthy volunteers. Stress caused decrease in FEV1%, FVC%, and PEF% compared to baseline in asthmatic patients, but not in healthy subjects. A single short duration episode of HRV-BF not only had a protective effect on stress-induced airway constriction, but also significantly augmented the level of FEV1% and FVC% as compared with their own baseline. A

The inhibitory effect of different patterns of low frequency stimulation on neuronal firing following epileptiform activity in rat hippocampal slices

Zahra Ghasemi, Nima Naderi, Amir Shojaei, Mohammad Reza Raoufy, Nooshin Ahmadirad, Victoria Barkley, Javad Mirnajafi-Zadeh
Journal PapersBrain research , Volume 1706 , 2019 March 1, {Pages 184-195 }

Abstract

Low frequency stimulation (LFS) has inhibitory effect on hyperexcitability during epileptic states. However, knowledge is lacking about LFS patterns that can exert an optimal antiepileptic effect. In this study, the effect of different numbers of pulses and current intensities of 1 Hz LFS applied at various time points of epileptiform activity was evaluated in high-K+ model of epileptiform activity (EA). LFS was applied to the Schaffer collaterals, and changes in the excitability of CA1 pyramidal neurons were measured using whole-cell patch-clamp recording. Six hundred and 900 pulses of LFS at two current intensities (equal to and 1.5 times greater than the current intensity sufficient to elicit a 5 mV EPSP) administered at the beginnin

The application of the extended Poincar? plot in the analysis of physiological variabilities

Reem Satti, Noor-Ul-Hoda Abid, Matteo Bottaro, Michele De Rui, Maria Garrido, Mohammad Reza Rauofy, Sara Montagnese, Alireza Mani
Journal PapersFrontiers in physiology , Volume 10 , 2019 January , {Pages 116 }

Abstract

The Poincar? plot is a geometrical technique used to visualise and quantify the correlation between two consecutive data points in a time-series. Since the dynamics of fluctuations in physiological rhythms exhibit long-term correlation and memory, this study aimed to extend the Poincar? plot by calculating the correlation between sequential data points in a time-series, rather than between two consecutive points. By incorporating this so-called lag, we hope to integrate a temporal aspect into quantifying the correlation, to depict whether a physiological system holds prolonged association between events separated by time. In doing so, it attempts to instantaneously characterise the intrinsic behaviour of a complex system. We tested this hyp

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