En
  • دکتری (1390)

    نانوفناوری

    دانشگاه صنعتی شریف، تهران، ایران

  • توسعه داربست های هوشمند و نانوسامانه های زیست سازگار برای کاربردهای مهندسی بافت و طب ترمیمی، دارورسانی هدفمند و ردیابی سلولهای بنیادی
  • اصلاح سطح داربست های فلزی زیست فعال و زیست تخریب پذیر برای کاربردهای مهندسی پزشکی
  • نانوبیوتکنولوژی

    زمینه های پژوهشی: نانوپزشکی ترمیمی

    کارشناس مسئول: افسانه احسان دوست

    هیات علمی همکار: الناز تمجید شبستری

    تلفن: 021-82884756

    مکان: دانشکده علوم زیستی-طبقه همکف-آزمایشگاه 5010

دکتر الناز تمجید دکتری خود را در سال ۱۳۹۰ در رشته نانوفناوری با رتبه اول و درجه عالی از پژوهشکده علوم و فناوری نانو دانشگاه صنعتی شریف دریافت کرد. ایشان پس از گذراندن دوره های پسادکتری در دانشگاههای تورنتو و صنعتی شریف، به عنوان استادیار در سال 1393 به دانشگاه تربیت مدرس پیوست. در حال حاضر ایشان دانشیار (از سال 1398) و مدیر گروه نانوزیست فناوری (از سال 1399) دانشگاه تربیت مدرس است. دکتر تمجید با موسسات و دانشگاههای بین المللی ماکس پلانک، فرانهوفر، تورنتو و تامپره همکاری علمی دارد. ایشان عضویت در هیات تحریریه مجله ساینتیفیک ریپورتز، گرنت بین المللی اراسموس پلاس (اتحادیه اروپا)، کمیته علمی و سخنران مدعو کنفرانس های بین المللی، منتخب ساخت نمونه اولیه (نانومچ) در جشنواره نانو، بورس استعدادهای درخشان (دکتری) و جشنواره خوارزمی (بخش دانش آموزی)، چاپ ۴۰ مقاله و ارائه ۳۰ سخنرانی علمی در کنفرانسهای بین المللی و پتنت داخلی را در رزومه کاری خود دارد. حوزه پژوهشی ایشان توسعه نانوزیستمواد برای کاربردهای مهندسی پزشکی و چاپ سه بعدی است.

ارتباط

رزومه

Biomimetic nanoengineered scaffold for enhanced full-thickness cutaneous wound healing

Nooshin Zandi, Banafsheh Dolatyar, Roya Lotfi, Yousef Shallageh, Mohammad Ali Shokrgozar, Elnaz Tamjid, Nasim Annabi, Abdolreza Simchi
Journal PapersActa Biomaterialia , Volume 124 , 2021 April 1, {Pages 191-204 }

Abstract

Wound healing is a complex process based on the coordinated signaling molecules and dynamic interactions between the engineered scaffold and newly formed tissue. So far, most of the engineered scaffolds used for the healing of full-thickness skin wounds do not mimic the natural extracellular matrix (ECM) complexity and therefore are not able to provide an appropriate niche for endogenous tissue regeneration [1]. To address this gap and to accelerate the wound healing process, we present biomimetic bilayer scaffolds compositing of gelatin nanofibers (GFS) and photocrosslinkable composite hydrogels loaded with epidermal growth factors (EGF). The nanofibers operate as the dermis layer, and EGF-loaded composite hydrogels acted as the epidermis

Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings

Mohammad Amin Khalili, Elnaz Tamjid
Journal PapersScientific Reports , Volume 11 , Issue 1, 2021 April 21, {Pages 13-Jan }

Abstract

Magnesium-based implants (MBIs) have recently attracted great attention in bone regeneration due to elastic modulus similar to bone. Nevertheless, the degradation rate and hydrogen release of MBIs in the body have to be tackled for practical applications. In the present study, we present a metal–organic framework (MOF) nanoplates to reduce the degradation rate of AZ91 magnesium alloy. Zeolitic imidazolate frameworks (ZIF-8) with a specific surface area of 1789 m 2 g− 1 were prepared by solvothermal methods, and after dispersion in a chitosan solution (10% w/w), the suspension was electrospun on the surface of AZ91 alloy. Studying the degradation rate in simulated body fluid (SBF) by electrochemical analysis including potentiodynamic pol

In vitro Corrosion Behavior and Biological Properties of Magnesium-Zinc-Calcium Alloy Coated with Polycaprolactone Nanofibers

SH Hadavi, R Soltani, E Tamjid, R Mehdinavaz Aghdam
Journal Papers , , {Pages }

Abstract

The effect of laser frequency on roughness, microstructure, cell viability and attachment of Ti6Al4V alloy

Kimia Rafiee, Homam Naffakh-Moosavy, Elnaz Tamjid
Journal PapersMaterials Science and Engineering: C , Volume 109 , 2020 April 1, {Pages 110637 }

Abstract

Titanium alloys are commonly used in orthopedic devices due to their good corrosion resistance, high specific strength and excellent biological response. The direct contact between the implant surface and the host tissue results in notable effect of surface properties such as surface topography on the biological responses. The aim of this study is to investigate the effect of frequency of pulsed Nd-YAG laser on Ti6Al4V alloy surface topography and its influence on the improvement of biocompatibility while other laser parameters kept constant. The range of applied frequency values were selected from 1 to 20?Hz. The range of surface roughness was found between 452?nm and 3.37?μm. The untreated sample and also samples with the highest and the

Core-sheath gelatin based electrospun nanofibers for dual delivery release of biomolecules and therapeutics

Nooshin Zandi, Roya Lotfi, Elnaz Tamjid, Mohammd Ali Shokrgozar, Abdolreza Simchi
Journal PapersMaterials Science and Engineering: C , Volume 108 , 2020 March 1, {Pages 110432 }

Abstract

Coaxial electrospinning with the ability to use simultaneously two separate solvents provides a promising strategy for drug delivery. Nevertheless, controlled release of hydrophilic and sensitive therapeutics from slow biodegradable polymers is still challenging. To address this gap, we fabricated core-sheath fibers for dual delivery of lysozyme, as a model protein, and phenytoin sodium as a small therapeutic molecule. The sheath was processed by a gelatin solution while the core fibers were fabricated from an aqueous gelatin/PVA solution. Microstructural studies by transmission and scanning electron microscopy reveal the formation of homogeneous core-sheath nanofibers with an outer and inner diameter of 180???48?nm and 106???30?nm, respect

Surface modification of biodegradable AZ91 magnesium alloy by electrospun polymer nanocomposite: Evaluation of in vitro degradation and cytocompatibility

Z Panahi, E Tamjid, M Rezaei
Journal PapersSurface and Coatings Technology , 2020 February 11, {Pages 125461 }

Abstract

Magnesium alloys have recently attracted significant attention for the fabrication of biodegradable orthopedic implants and cardiovascular stents. Nevertheless, the high degradation rate of magnesium alloys under physiological conditions is still challenging. We present a surface modification strategy to tailor the degradation rate and in vitro cell behavior of AZ91 alloy through electrospinning of continuous poly (ε-caprolactone) fibers containing bioactive glass nanoparticles (~30 nm). The average thickness of the nanocomposite film and the fibers are 30 μm ? 5 and 300 ? 31 nm, respectively. Electrochemical studies in simulated body fluid and standard immersion corrosion tests have determined that the degradation rate of t

A study on cytotoxicity, hemocompatibility, and antibacterial properties of tetracycline hydrochloride-loaded PCL-based composite scaffolds for bone tissue engineering

Mahsa Bohlouli, Elnaz Tamjid, Soheila Mohammadi, Maryam Nikkhah
Journal PapersModares Journal of Biotechnology , Volume 11 , Issue 1, 2020 March 10, {Pages 0-0 }

Abstract

Aims: Since one of the main problems in bone tissue repair is bacterial infections, recently the development of drug-eluting nanocomposite scaffolds for bone regenerative medicine applications has attracted significant attention. Materials & Methods: In the present study, polycaprolactone (PCL)-based composite scaffolds containing 10% V titanium dioxide nanoparticles (21nm), and bioactive glass particles (6?m), were prepared without drug and also loaded by tetracycline hydrochloride (TCH) antibiotic (0.57 and 1.15 mg/mL) through solvent casting method for bone tissue engineering applications. Structural characterizations based on scanning electron microscopy and FTIR analysis were utilized to study the chemical bonds of glass/ceramic partic

Sustainable drug release from highly‐porous and architecturally‐engineered composite scaffolds prepared by 3D printing

Elnaz Tamjid, Mahsa Bohlouli, Soheila Mohammadi, Hossein Alipour, Maryam Nikkhah
Journal PapersJournal of Biomedical Materials Research Part A , 2020 March 5, {Pages }

Abstract

Additive manufacturing techniques have evolved novel opportunities for the fabrication of highly‐porous composite scaffolds with well‐controlled and interconnected pore structures which is notably important for tissue engineering. In this work, poly (ԑ‐caprolactone) (PCL)‐based composite scaffolds (average pore diameter of 450 μm, and strut thickness of 400 μm) reinforced with 10 vol% bioactive glass particles (BG; ~6 μm) or TiO2 nanoparticles (~21 nm), containing different concentrations of Tetracycline hydrochloride (TCH) as antimicrobial agent were prepared by 3D printing. In order to investigate the effect of fabrication process and scaffold geometry on the biocompatibility, drug release kinetics and antibacterial

A Study on Cytotoxicity, Hemocompatibility, and Antibacterial Properties of Tetracycline Hydrochloride-Loaded PCL-Based Composite Scaffolds for Bone Tissue Engineering Applications

Mahsa Bohlouli, Elnaz Tamjid, Soheila Mohammadi, Maryam Nikkhah
Journal PapersModares Journal of Biotechnology , Volume 11 , Issue 1, 2020 March 10, {Pages 0-0 }

Abstract

Aims: Since one of the main problems in bone tissue repair is bacterial infections, recently the development of drug-eluting nanocomposite scaffolds for bone regenerative medicine applications has attracted significant attention. Materials & Methods: In the present study, polycaprolactone (PCL)-based composite scaffolds containing 10% V titanium dioxide nanoparticles (21nm), and bioactive glass particles (6?m), were prepared without drug and also loaded by tetracycline hydrochloride (TCH) antibiotic (0.57 and 1.15 mg/mL) through solvent casting method for bone tissue engineering applications. Structural characterizations based on scanning electron microscopy and FTIR analysis were utilized to study the chemical bonds of glass/ceramic partic

Drug-eluting PCL/graphene oxide nanocomposite scaffolds for enhanced osteogenic differentiation of mesenchymal stem cells

Fatemeh Rostami, Elnaz Tamjid, Mehrdad Behmanesh
Journal PapersMaterials Science and Engineering: C , 2020 May 20, {Pages 111102 }

Abstract

Recently, drug-eluting nanofibrous scaffolds have attracted a great attention to enhance the cell differentiation through biomimicking the extracellular matrix (ECM) in regenerative medicine. In this study, electrospun nanocomposite polycaprolactone (PCL)-based scaffolds containing synthesized graphene oxide (GO) nanosheets and osteogenic drugs, i.e. dexamethasone and simvastatin were fabricated. The physicochemical and surface properties of the scaffolds were investigated through FTIR, wettability, pH, and drug release studies. The cell viability, differentiation, and biomineralization were studied on mesenchymal stem cells (MSCs) by Alamar Blue, alkaline phosphatase (ALP) activity, and Alizarin Red-S staining, respectively. Uniformly dist

Sustainable drug release from highly porous and architecturally engineered composite scaffolds prepared by 3D printing

Elnaz Tamjid, Mahsa Bohlouli, Soheila Mohammadi, Hossein Alipour, Maryam Nikkhah
Journal PapersJournal of Biomedical Materials Research Part A , Volume 108 , Issue 6, 2020 June , {Pages 1426-1438 }

Abstract

Additive manufacturing techniques have evolved novel opportunities for the fabrication of highly porous composite scaffolds with well‐controlled and interconnected pore structures which is notably important for tissue engineering. In this work, poly (ε‐caprolactone) (PCL)‐based composite scaffolds (average pore diameter of 450 μm and strut thickness of 400 μm) reinforced with 10 vol% bioactive glass particles (BG; ∼6 μm) or TiO2 nanoparticles (∼21 nm), containing different concentrations of tetracycline hydrochloride (TCH) as an antimicrobial agent, were prepared by 3D printing. In order to investigate the effect of fabrication process and scaffold geometry on the biocompatibility, drug release kinetics, and antibac

Nanoengineered shear-thinning and bioprintable hydrogel as a versatile platform for biomedical applications

Nooshin Zandi, Ehsan Shirzaei Sani, Ebrahim Mostafavi, Dina M Ibrahim, Bahram Saleh, Mohammad Ali Shokrgozar, Elnaz Tamjid, Paul S Weiss, Abdolreza Simchi, Nasim Annabi
Journal PapersBiomaterials , 2020 October 19, {Pages 120476 }

Abstract

The development of bioinks based on shear-thinning and self-healing hydrogels has recently attracted significant attention for constructing complex three-dimensional physiological microenvironments. For extrusion-based bioprinting, it is challenging to provide high structural reliability and resolution of printed structures while protecting cells from shear forces during printing. Herein, we present shear-thinning and printable hydrogels based on silicate nanomaterials, laponite (LA), and glycosaminoglycan nanoparticles (GAGNPs) for bioprinting applications. Nanocomposite hydrogels (GLgels) were rapidly formed within seconds due to the interactions between the negatively charged groups of GAGNPs and the edges of LA. The shear-thinning behav

Sensitive Voltammetric Detection of Melatonin in Pharmaceutical Products by Highly Conductive Porous Graphene-Gold Composites

Reza Rahmati, Amir Hemmati, Rahim Mohammadi, Amir Hatamie, Elnaz Tamjid, Abdolreza Simchi
Journal PapersACS Sustainable Chemistry & Engineering , 2020 December 2, {Pages }

Abstract

This work presents a novel melatonin sensor based on unfunctionalized macroporous graphene networks decorated with gold nanoparticles for the differential pulse voltammetric detection of melatonin in pharmaceutical products. Highly porous graphene structures were prepared by metallic template-assisted chemical vapor deposition, and their active surface area and electrocatalytic activity were improved by electrochemical deposition of gold nanoparticles (50–250 nm) on their struts. The graphene-gold electrodes present a highly sensitive performance toward electro-oxidation of melatonin with a wide linear range of 0.05–50 μM, a low detection limit of 0.0082 μM (3σ/m), and a significant sensitivity of 16.219 μA μM–1 cm–2. Therefore

Modification of the Interface Between Degradable Magnesium Alloy and Physiological Environment for Controlled Biodegradation Using Fibrous Polymer/Metal-Organic Framework?…

Mohammad Amin Khalili, Elnaz Tamjid
Journal Papers , 2020 December 28, {Pages }

Abstract

Magnesium-based implants (MBIs) have recently attracted great attention in bone regeneration due to elastic modulus similar to bone. Nevertheless, the degradation rate and hydrogen release of MBIs in the body have to be tackled for practical applications. In the present study, we present a metal organic framework (MOF) nanoplates to reduce the degradation rate of AZ91 magnesium alloy. Zeolitic imidazolate frameworks (ZIF-8) with speci c surface area of 1789 m2. g-1 were prepared by solvothermal methods, and after dispersion in a chitosan solution (10% w/w), the suspesnsion was electrospun on the surface of AZ91 alloy. Studying of the degradation rate in simulated body uid (SBF) by electrochemical analysis including potentiodynamic polarizat

Modification of the Interface Between Degradable Magnesium Alloy and Physiological Environment for Controlled Biodegradation Using Fibrous Polymer/Metal-Organic Framework …

MA Khalili, E Tamjid
Journal Papers , , {Pages }

Abstract

Modification of bacterial cellulose/keratin nanofibrous mats by a tragacanth gum-conjugated hydrogel for wound healing

Amir Azarniya, Elnaz Tamjid, Niloofar Eslahi, Abdolreza Simchi
Journal PapersInternational journal of biological macromolecules , 2019 May 6, {Pages }

Abstract

To enhance physicomechanical properties and bioactivity of fibrous membranes for wound dressing and tissue engineering applications, novel composite scaffolds consisting of fibrous mats and thermosensitive hydrogel particles were prepared by concurrent electrospinning and electrospraying technique. The composite scaffolds were composed of keratin/bacterial cellulose fibers (150 ? 43 nm) which are hybridized with hydrogel particles (500 nm to 2 μm) based on nonionic triblock copolymers conjugated with Tragacanth gum (TG). FTIR and H-NMR studies indicated ester reactions between carboxylated copolymers and TG through carbodiimide crosslinker chemistry. The hydrogel particles were uniformly embedded into fibrous network at fiber jun

Fabrication of hierarchically porous silk fibroin-bioactive glass composite scaffold via indirect 3D printing: Effect of particle size on physico-mechanical properties and in?…

Mina Razaghzadeh Bidgoli, Iran Alemzadeh, Elnaz Tamjid, Mona Khafaji, Manouchehr Vossoughi
Journal PapersMaterials Science and Engineering: C , Volume 103 , 2019 October 1, {Pages 109688 }

Abstract

In order to regenerate bone defects, bioactive hierarchically scaffolds play a key role due to their multilevel porous structure, high surface area, enhanced nutrient transport and diffusion. In this study, novel hierarchically porous silk fibroin (SF) and silk fibroin-bioactive glass (SF-BG) composite were fabricated with controlled architecture and interconnected structure, by combining indirect three-dimensional (3D) inkjet printing and freeze-drying methods. Further, the effect of 45S5 Bioactive glass particles of different sizes (<100 nm and 6 μm) on mechanical strength and cell behavior was investigated. The results demonstrated that the hierarchical structure in this scaffold was composed of two levels of pores in the order of 5

Preparation of liposomal doxorubicin-graphene nanosheet and evaluation of its in vitro anti-cancer effects

Samira Tajvar, Soheila Mohammadi, Alireza Askari, Sajjad Janfaza, Maryam Nikkhah, Elnaz Tamjid, Saman Hosseinkhani
Journal PapersJournal of liposome research , Volume 29 , Issue 2, 2019 April 3, {Pages 163-170 }

Abstract

In recent years there has been much interest in development of multifunctional drug delivery systems. In this work, liposomes that contain doxorubicin (Dox), a potent anticancer drug, and graphene nanosheets (GNS) were prepared. The GNSs have excellent optical properties, such as photoluminescence which enables tracking of the liposomes, high absorption in ultra violet region of electromagnetic spectrum which can be exploited in photodynamic and photothermal therapy, and low toxicity to mammalian cells. Nanoliposomes were prepared using the thin film hydration method. Dox and GNSs were loaded to the liposomes during the hydration of the lipid film. Liposomes were characterized and the profile of in vitro drug release, cellular uptake, and c

Biomimetic Proteoglycan Nanoparticles for Growth Factor Immobilization and Delivery

Nooshin Zandi, Ebrahim Mostafavi, Mohammad Shokrgozar, Elnaz Tamjid, Thomas Webster, Nasim Annabi, A Simchi
Journal PapersBiomaterials Science , 2019 January , {Pages }

Abstract

The delivery of growth factors is often challenging due to their short half-life, low stability, and rapid disactivation. In native tissues, the sulfated residual of glycosaminoglycan (GAG) polymer chains of proteoglycans immobilizes growth factors through the proteoglycans/proteins’ complexation with nanoscale organization. These biological assemblies can influence growth factor-cell surface receptor interactions, cell differentiation, cell-cell signaling, as well as the mechanical properties of the tissues. Here, we introduce a facile procedure to prepare novel biomimetic proteoglycan nanocarriers, based on naturally-derived polymers, for the immobilization and controlled release of growth factors. We developed polyelectrolyte complex n

A Study on Biofilm Formation, Antibacterial Properties and Cell Viability of Poly (ε-Caprolactone)-Based Electrospun Nanofibrous Scaffold

T Peimaneh Abedi Mohtasab, E Tamjid, R Haji-Hosseini
Journal PapersModares Journal of Biotechnology , Volume 10 , Issue 3, 2019 September 10, {Pages 373-380 }

Abstract

Aims: Recently, polymer-based nanofibrous scaffolds have attracted great attention due to their significant antibacterial properties in the field of dermatological applications. In this study, a polycaprolactone-based nanofibrous scaffold has been fabricated using the electrospinning method. The aim of this study was to evaluate the antibacterial effect of electrospun nanofibrous structures. Materials and Methods: In this experimental study, the structure and bacterial attachment on polymeric nanofibrous scaffolds were studied by Scanning Electron Microscopy (SEM). In addition, antibacterial properties of nanofibrous scaffolds were studied on two gram-negative bacteria of Escherichia coli and Pseudomonas aeruginosa and two gram-positive bac

دروس نیمسال جاری

  • كارشناسي ارشد
    زيست مواد ( واحد)
    دانشکده علوم زیستی، گروه ريز زيست فناوري (نانو بيوتكنولوژي)
  • كارشناسي ارشد
    علوم و مهندسي سطح ( واحد)
  • كارشناسي ارشد
    فلزات و كاربرد آن در مهندسي پزشكي ( واحد)

دروس نیمسال قبل

  • دكتري
    روش هاي آناليز ريززيست ساختارها ( واحد)
    دانشکده علوم زیستی، گروه ريز زيست فناوري (نانو بيوتكنولوژي)
  • 1397
    شاهدي علي اباد, فائزه
    ساخت ومشخصه يابي هيدروژل كامپوزيتي آلژينات فيبروئين ابريشم / لپونيت به منظور كاربرد در مهندسي بافت غضروف
  • 1397
    بهنام نيك, سجاد
  • 1397
    شكوه نژاد, نگار
  • 1397
    كريمي, مهسا
  • 1398
    بزاززاده, الهه
  • 1398
    احمدي, سلمان
  • 1396
    احسان دوست, افسانه
    توليد جوهر زيستي فيبروئين ابريشم حاوي سلول و نانوذرات زيست فعال بيوگلس جهت چاپ سه بعدي در كاربردهاي مهندسي بافت پوست
  • 1397
    نجفي انامقي, پروين
  • عضو هیات تحریریه مجله ساینتیفیک ریپورتز، 1397 تاکنون
  • نماینده دانشکده علوم زیستی در دفتر همکاریهای علمی بین المللی، 1397 تاکنون
  • مدیر گروه نانوزیست فناوری، 1399 تاکنون
  • گرنت بین المللی اراسموس پلاس، اتحادیه اروپا، 2019-2023

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