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  • دکتری (1378)

    سازگاریهای عصبی-عضلانی به فعالیت بدنی

    مونترال، مونترال، کانادا

  • دکتری (1378)

    فیزیولوژی ورزش

    مونترال، مونترال، کانادا

  • دکتری (1377)

    تربیت بدنی وعلوم ورزشی

    کانادا، کانادا

  • کارشناسی‌ارشد (1368)

    تربیت بدنی وعلوم ورزشی

    دانشگاه تربیت مدرس،

  • کارشناسی (1365)

    تربیت بدنی وعلوم ورزشی

    دانشگاه خوارزمی،

  • سازگاریهای عصبی و عضلانی به فعالیت بدنی
  • فیزیولوژی ورزش

    داده ای یافت نشد

    ارتباط

    رزومه

    Exercise Training Ameliorates Cognitive Dysfunction in Amyloid Beta-injected Rat Model: Possible Mechanisms of Angiostatin/VEGF Signaling

    ALIASGHAR Zarezadehmehrizi, Junyoung Hong, Jong-hae Lee, Hamid Rajabi, Reza Gharakhanlou, Naser Naghdi, Mohammad Azimi, Yoonjung Park
    Journal Papers , 2021 February 19, {Pages }

    Abstract

    Vascular endothelial growth factor (VEGF) regulates angio/neurogenesis and also tightly links to the pathogenesis of Alzheimer’s disease (AD). Although exercise has a bene cial effect on neurovascular function and cognitive function, the direct effect of exercise on VEGF-related signaling and cognitive de cit in AD are incompletely understood. Therefore, the purpose of this study was to investigate the protective effect of exercise on angiostatin/VEGF cascade and cognitive function in AD model rats. Wistar male rats were randomly divided into ve groups: control (CON), injection of DMSO (Sham-CON), CON-exercise (sham-EX), intrahippocampal injection of Aβ (AD), and AD-exercise (AD-EX). Rats in EX groups underwent treadmill exercise for 4 w

    Monitoring training in women's volleyball: Supine or seated heart rate variability?

    M Rabbani, H Agha-Alinejad, R Gharakhanlou, A Rabbani, AA Flatt
    Journal Papers , , {Pages }

    Abstract

    Evaluation of the Frequency of polymorphism rs1815739 (ACTN3) and rs8192678 (PPARGC1A) among professional male soccer players of Iranian Premier League: case-control study

    S Aboubakri, R Ghara Khanlou, M Molanouri Shamsi
    Journal Papers , , {Pages }

    Abstract

    Physical activity may contribute to brain health in multiple sclerosis: An MR volumetric and spectroscopy study

    R Negaresh, R Gharakhanlou, MA Sahraian, M Abolhasani, RW Motl, ...
    Journal Papers , , {Pages }

    Abstract

    Effect of aerobic training and L-carnitine on MDA, GPX and Hippocampal Neurogenesis in Diabetic Rats

    Alireza Shahsavar, Hamid Rajabi, Reza Gharakhanlou, Mohammad Reza Dehkhoda
    Journal PapersIranian journal of diabetes and obesity , 2020 July 7, {Pages }

    Abstract

    Objective: L-carnitine is associated with an increase in antioxidant enzymes activities and reduction in oxidative damage. The aim of this study was to evaluate the effect of aerobic training and Lcarnitine cconsumption on hippocampal oxidative stress and neurogenesis factors in diabetic rats.

    The effect of aerobic exercise on collagen type I and IV gene expression and collagen type I protein changes in the sciatic nerve of diabetic rats

    Nahid Jalilian Hamed, Reza Gharakhanlou, Maghsoud Peeri
    Journal PapersNovelty in Biomedicine , 2020 June 16, {Pages }

    Abstract

    Objectives: Neuropathy is one of the complications of diabetes, probably due to the destruction of the extracellular matrix and the thickening of the peripheral nerve basement membrane. But its mechanisms and the impact of exercise on these disorders are not fully understood. The purpose of the present study was to investigate the effect of aerobic exercise on collagen levels of type I and IV and collagen type I protein changes in the sciatic nerve of diabetic rats.Methods: Eighteen 10-week-old Wistar male rats weighing 250?20 g were randomly divided into three groups of healthy control (n= 6), diabetic (n= 6) and diabetic+ aerobic exercise (n= 6). For this purpose, after introduction and adaptation of rats to new environment, diabetes was

    The Effect of Six Weeks Increasing Endurance Training and Consuming L-Carnitine on Apoptotic Factors of Bax, Bcl-2 and Bax/Bcl-2 in the Hippocampus of Diabetic Rats

    Alireza Shahsavar, Hamid Rajabi, Reza Gharakhanlou, Mohammad Reza Dehkhoda
    Journal PapersJournal of North Khorasan University of Medical Sciences , Volume 11 , Issue 4, 2020 February 10, {Pages 61-67 }

    Abstract

    Introduction: Exercise is an effective factor in the prevention, treatment and rehabilitation of many metabolic disorders. The purpose of this study was to determine the effect of six weeks’ endurance training and consuming L-carnitine on apoptotic factors in the hippocampus of diabetic rats. Methods: In this experimental study, 45 Wistar male rats, weighing between 250 and 300 grams, were randomly divided into six groups. Rats became diabetic by being injected with 95 mg nicotinic amide and after 15 minutes, 55mg streptozotocin (STZ). Rats receiving Lcarnitine, daily received 100 milligrams of l-carnitine orally. The endurance training protocol consisted of five sessions, starting with 20 minutes at 10 speeds in 0 degrees slope in the fi

    How perception of time differs under different situations: Different behaviors of the central nervous system as a complex dynamic system.

    Yashar Sarbaz, Hakimeh Pourakbari
    Journal Papers , 2020 January , {Pages }

    Abstract

    The letter discusses how the perception of time differs under different situations, and as a dynamic response of the CNS. Thus, it is better to consider CNS functions from the perspective of complex dynamic systems and to consider chaotic systems, which are well known as sensitive, to be dependent on initial conditions. Our idea is that CNS function is like chaotic systems and under different states and conditions the parameters of the system change. Parameter changes lead to different outcomes of such systems and different processing of information, and eventually our perception of time alters. It is, however, difficult to quantify CNS behavior; some global features can be employed to characterize complex dynamic systems. More information

    The Effect of Endurance Training on Fibronectin Gene Expression of the Sciatic Nerve in Diabetic Rats

    Nahid Jalilian Hamed, Reza Gharakhanlou, Maghsoud Peeri
    Journal PapersActa Medica Iranica , 2020 July 15, {Pages }

    Abstract

    -Diabetic neuropathy can cause disorders in axon transmission, changes in the extracellular matrix, and peripheral nerve damages. However, its mechanism, along with the beneficial effects of exercise on these disorders is not entirely clear. The aim of the current study was to assess changes in fibronectin mRNA gene expression level of the sciatic nerve in rats with streptozotocin-induced diabetes after endurance training. Eighteen male Wistar rats (10 weeks old with 250?20 gr weight) were randomly assigned to three groups, including healthy, induced diabetes and induced diabetes plus endurance training. Induction of diabetes was conducted using an intraperitoneal injection of a single dose of streptozotocin (STZ). Neuropathy was confirmed

    Effect of 8 weeks of Aerobic Training on Genes Expression of Hypoxia Inducible Factor HIF-1α, Vascular Endothelial Growth Factor (VEGF) and Angiostatin in Hippocampus of Male?…

    Aliasghar Zarezadehmehrizi, Hamid Rajabi, Reza Gharakhanlou, Naser Naghdi, Seyed Mohammad Ali Azimidokht
    Journal PapersSSU_Journals , Volume 27 , Issue 11, 2020 February 10, {Pages 2063-2075 }

    Abstract

    Methods: 18 adult male Wistar rats (190?10 gr) were randomly divided into 3 groups: control, sham and aerobic training. Ratsin the training group performed 8 weeks of aerobic training (5 sessions per week) on a treadmill. 24 hours after the last session of exercise, rats were decapitated and the hippocampus were carefully removed and rapidly frozen in liquid nitrogen, then stored at-80 C for further analysis. Real-Time-PCR method was used to measure the expression of genes in the hippocampus. The data were analyzed by SPSS 18 software. Comparisons between groups were performed by one-way ANOVA and followed by post-hoc analysis Tukey test. All statistically significant was set at P< 0.05.Results: The results showed aerobic training significa

    Exercise training and cognitive performance in persons with multiple sclerosis: A systematic review and multilevel meta-analysis of clinical trials

    Reza Gharakhanlou, Leonie Wesselmann, Annette Rademacher, Amit Lampit, Raoof Negaresh, Mojtaba Kaviani, Max Oberste, Robert W Motl, Brian M Sandroff, Jens Bansi, Julien S Baker, Christoph Heesen, Philipp Zimmer, Florian Javelle
    Journal Papers , 2020 May 11, {Pages 1.3524585209e+15 }

    Abstract

    Background:Cognitive impairment is common, debilitating, and poorly managed in persons with multiple sclerosis (pwMS). Exercise training might have positive effects on cognitive performance in pwMS, yet the overall magnitude, heterogeneity, and potential moderators remain unclear.Objective:This three-level meta-analysis aims to identify the effects of exercise training and those of exercise modalities on global and domain-specific cognitive performance in pwMS.Methods:MEDLINE, PsycInfo, SportDiscus, CENTRAL, and EMBASE were screened for randomized and non-randomized clinical trials from inception to 27 January 2020, yielding 3091 articles. Based on titles and abstracts, 75 articles remained in the selection process. After full-text evaluati

    Effect of a bout of resistance exercise in warm weather on Immune and hormonal responses

    AREZOO ESKANDARI, ALINEJAD HAMID AGHA, REZA GHARAKHANLOU, Mohammad Fashi
    Journal Papers , Volume 8 , Issue 15, 2020 January 1, {Pages 74-84 }

    Abstract

    Background and Aim: Exercise in warm weather can lead to a change in stress hormones and immune factors as compare to normal conditions. The present study aimed to investigate the effects of a bout of resistance exercise in a warm weather on Immune and hormonal responses. Materials and Methods: Eight male students with an average of 27?2 years participated in this study. The exercise program was performed for two conditions, at the first week it done in a normal temperature (20 C) and then it performed in a warm temperature (35 C) in the following week. Blood samples were taken one hour before, immediately after and one hour after of about a resistance exercise including 10 repetition, 3 sets up to 70 percent of 1 repetition moximum. In bot

    The Changes of Heart miR-1 and miR-133 Expressions following Physiological Hypertrophy Due to Endurance Training

    Mohammad Fathi, Reza Gharakhanlou, Razieh Rezaei
    Journal PapersCell Journal (Yakhteh) , Volume 22 , Issue Suppl 1, 2020 January , {Pages 133 }

    Abstract

    ObjectiveMicroRNAs (miRNAs) play a key role in the development of the heart. Recent studies have shown that miR-1 and miR-133 are key regulators of cardiac hypertrophy. Therefore, we aimed to evaluate the effect of an endurance training (ET) program on the expressions of these miRNAs and their transcriptional network.Materials and MethodsIn this experimental study, cardiac hypertrophy was induced by 14 weeks of ET for 1 hour per day, 6 days per week at 75% VO2 max). The rats (221?23 g) in the experimental (n= 7) and control (n= 7) groups were anesthetized to evaluate heart morphology changes by echocardiography. Next, we evaluated expressions of miR-1 and miR-133, and heart and neural crest derivatives express 2 (Hand2), Mef2c, histone deac

    The Concurrent Effect of Eccentric Resistance Training and Blood Flow Occlusion on STAT3 and MyF5 Gene Expressions Affecting the Activation of Satellite Cells Growth in Non?…

    Mohammad Ali Tabibi, Azam Mosavian, Abasali Gaeini, R Ghara Khanlou, Reza Nuri, Mohamadreza Kordi
    Journal PapersJournal of Sport Biosciences , Volume 12 , Issue 2, 2020 August 22, {Pages 143-154 }

    Abstract

    The aim of the present study was to investigate the effect of resistance training and blood flow occlusion on gene expression of signal transfer agent and activator of transcription (STAT3) and muscle-forming agent 5 (Myf5) in non-athlete active young subjects. 20 men (age range 25 ? 5 years) were randomly divided into two groups (ach group 10 subjects): eccentric resistance training with and without blood flow restriction (BFR). Using isokinetic set, eccentric resistance training protocol (ECC RET) including about 70 repetitions of knee extensor muscles was performed. Occlusion was created using pneumatic pressure device. After local anesthesia with lidocaine 1% and norepinephrine, blood samples were collected from active vastus lateralis

    The effect of aerobic training and intake of L-Carnitine on Malonyl-CoA and CPT2 enzymes in hippocampus tissue of diabetic rats

    Mahdi Angouti, Hamid Rajabi, Reza Gharakhanlou, Mohammad Reza Dehkhoda
    Journal PapersRazi Journal of Medical Sciences , Volume 27 , Issue 4, 2020 January , {Pages 122-130 }

    Abstract

    Background: Diabetes is known as one of the diseases that has imposed many health, social and economic problems on human societies and has spread widely in recent decades (1). Glucose metabolism and related disorders for the central nervous system (CNS) and astrocytes, which are the most important glial cells of the central nervous system; It is important. Therefore, disorders of the hypothalamus, cerebral cortex and hippocampus, vascular disorders of the brain, etc. are among the complications of diabetes on the central nervous system (3). Among the brain regions, the hippocampus is one of the most sensitive areas that is vulnerable to harmful factors such as ischemia, stress and especially diabetes, during which it undergoes neurophysiolo

    The Effect of Eight Weeks of Aerobic Training on Some Factors Involved in Cholesterol Metabolism in the Hippocampus and Its Role in Improving the Cognitive Function of Male?…

    Z SARLAK, M MOAZZAMI, HOSSEINI SR ATTARZADEH, R GHARAKHANLOU
    Journal Papers , Volume 12 , Issue 45, 2020 January 1, {Pages 61-78 }

    Abstract

    Although the metabolism of blood lipids has been widely considered in studies, lipid metabolism in the brain has attracted more attention in recent years due to its association with some neurological disorders. Recent studies have shown that a number of risk factors for early onset of Alzheimer's are associated with cholesterol metabolism. Therefore, the purpose of this study was to investigate the effect of eight weeks of aerobic training on some factors involved in the metabolism of cholesterol in the hippocampus and its role in improving the cognitive function of male Wistar rats. The subjects of this study were 26 adult male Wistar 8 weeks old (weight 195?20 g). At first, they were randomly divided into two groups: exercise (training on

    An Investigation of the Effect of Upper Limb Resistance Training after Lower Limb Immobilization on FoxO3a, MuRF1 and MAFbx Gene Expressions of Soleus Muscle in Trained Rats

    Sedigheh Rezaeipour, Mohammad Reza Kordi, Abbas Ali Gaeini, Reza Gharakhanloo
    Journal Papers , Volume 11 , Issue 4001088, 2020 January 1, {Pages 81-90 }

    Abstract

    Inactivity can ultimately lead to obesity and activation of the proteolysis messenger pathways, which decreases muscle mass and skeletal muscle contractile power. The aim of this study was to investigate the effect of resistance training during the period of muscular inactivity on the expressions of atrophy processes regulatory genes of soleus muscle in the trained rats. 18 male Sprague Dawley rats were divided into two groups: control (n= 6) and endurance training (n= 12). Endurance training rats ran on a treadmill for 6 weeks and 5 sessions per week. Then, their lower limbs were immobilized for 7 days by plaster cast method and they were divided into two groups: immobilization (n= 6) and resistance training (n= 6). Resistance training and

    Developing a Strategic Plan for Monitoring the Well-Being and Physical Activity of Students in Iranian Governmental Universities

    Reza Gharakhanlou, Mohammadhossein Ghorbani, Mahdi Bayati, Amir Shams
    Journal PapersResearch on ٍEducational Sport , Volume 8 , Issue 19, 2020 August 22, {Pages 17-38 }

    Abstract

    The purpose of this study was to develop a strategic plan for monitoring the well-being and physical activity of Iranian students. This research is a mixed (qualitative-quantitative) research and has been conducted in the field. The statistical population of the study consisted of all governmental universities throughout the country and all other experts in the field of student sport and student well-being monitoring. In the quantitative section, the sample consisted of 39 elites and supervisors of university well-being and sport counseling centers. According to the findings, the mission of the student well-being and Physical Activity system is "policy making, planning and implementation of student health monitoring, providing sports counse

    Amyloid-beta clearance in Alzheimer’s disease: Does exercise play a role?

    Reza Gharakhanlou, Davar Khodadadi
    Journal PapersAnnals of Alzheimer's and Dementia Care , Volume 4 , Issue 1, 2020 September 14, {Pages 018-020 }

    Abstract

    Alzheimer’s Disease (AD), the most common form of dementia, is characterized by progressive deficits in cognitive function. Amyloid-beta (Aβ) peptides are believed to play a decisive role in the pathology of AD. Improving the clearance of toxic Aβ has, therefore, become a therapeutic strategy for AD. Unfortunately, almost all of the drug candidates tested for AD, including the Aβ centric therapeutic approaches, until now have failed to exhibit any efficacy. Previous evidence suggested that aerobic exercise training contributes to the improvement of cognitive decline and slows down pathogenesis of AD; however, the exact mechanisms for this have not been fully understood. One of the most important beneficial effects of aerobic exercise o

    THE EFFECT OF AEROBIC TRAINING AND INTAKE OF L-CARNITINE ON PROTEIN LEVEL OF HIPPOCAMPUS CNTF AND CNTFR IN DIABETIC RATS

    Mahdi Angouti, Hamid Rajabi, Reza Gharakhanlou, Mohammad Reza Dehkhoda
    Journal PapersIranian Journal of Diabetes and Metabolism , Volume 20 , Issue 2, 2020 December 10, {Pages 83-92 }

    Abstract

    Background: Diabetes causes nerve tissue damage and ultimately death of nerve cells, especially in important areas such as the hippocampus. It seems that exercise training and anti-inflammatory supplements can moderate this condition. Therefore, the aim of this study was to determine the effect of aerobic training exercise and L-carnitine consumption on the levels of hippocampus CNTF and CNTFR proteins in diabetic rat.Methods: 45 Wistar rats between 250 to 300 gr were randomly divided into six groups, including healthy control groups, sham, diabetic control, diabetes+ aerobic exercise, diabetes+ L-carnitine supplementation and diabetes+ aerobic exercise+ L-carnitine supplementation. L-carnitine supplements were divided. Diabetic groups unde

    دروس نیمسال جاری

    • دكتري
      سازگاري هاي عصبي عضلاني با فعاليت ورزشي ( واحد)
      دانشکده علوم انسانی، گروه تربيت بدني

    دروس نیمسال قبل

    • كارشناسي ارشد
      بيو انرژتيك فعاليت ورزشي ( واحد)
      دانشکده علوم انسانی، گروه تربيت بدني
    • دكتري
      سازگاري هاي سلولي و مولكولي با فعاليت ورزشي ( واحد)
    • دكتري
      سمينار در فيزيولوژي ورزشي ( واحد)
    • 1397
      ولدي اطهر, محمد
      نقش پياز بويايي و تمرين هوازي بر شاخص‌هاي پلاستيسيته سيناپسي و عملكرد شناختي در موش‌هاي صحرايي نر بالغ
    • 1394
      قاسمي, پيمان
      تاثير تمرين هوازي قبل و بعد از القاي بيماري آلزايمر بر مقادير GDNF mRNA و TNFa وIL-10 نسبت IL-10 به TNF-a در هيپوكمپ موش هاي صحرايي نر ويستار
    • 1394
      قيوم زاده جويناني, مرتضي
    • 1395
      حسين پور, فاطمه
    • 1395
      حسين زاده, زينب
    • 1395
      زينلي طالخونچه, فرزانه
    • عضویت در شورای علمی بنیاد دانشنامه نگاری ایران
    • عضو کمیسیون تخصصی گروه علوم اجتماعی در هیات ممیزه
    • عضو کمیته ملی ورزش و تربیت بدنی وابسته به کمیسیون ملی یونسکو
    • عضو هیات اجرایی جذب دانشگاه تربیت مدرس
    • عضو هیات اجرایی جذب دانشگاه
    • عضو کمیته تخصصی علوم ورزشی گروه علوم اجتماعی و دفتر برنامه ریزی آموزش عالی
    • عضو شورای راهبری توسعه ورزش دانشگاهی
    • رئیس پژوهشگاه تربیت بدنی
    • عضو هیات تحریریه مجله Iranian Journal of Health Education & Health Promotion
    • عضو هیات تحریریه پژوهشنامه فیزیولوژی ورزشی کاربردی
    • عضو گروه تخصصی علوم ورزشی
    • عضو کارگروه بررسی صلاحیت عمومی دانشگاه تربیت مدرس (تمدید)
    • عضو افتخاری هیات رییسه فدراسیون ملی ورزش های دانشگاهی
    • رییس آکادمی ملی المپیک ج. ا.ایران
    • رییس آکادمی ملی المپیک ج. ا.ایران
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