En
  • دکتری (1392)

    علوم سلولی ومولکولی

    دانشگاه تهران، تهران، ایران

  • کارشناسی‌ارشد (1385)

    علوم سلولی و مولکولی

    دانشگاه تهران، تهران، ایران

  • کارشناسی (1383)

    میکروبیولوژی

    دلنشگاه اصفهان، اصفهان، ایران

  • مهندسی بافت
  • سلولهای بنیادی
  • نانوتکنولوژی در درمان سرطان
  • پروتئین نوترکیب

    دکتر فاطمه باقری دانش آموخته ممتاز مقطع دکتری علوم سلولی و مولکولی از دانشگاه تهران بوده و از سال 1393به عنوان استادیار در دانشکده مهندسی شیمی گروه بیوتکنولوژی دانشگاه تربیت مدرس مشغول به فعالیت است. زمینه های پژوهشی مورد علاقه وی مهندسی بافت با استفاده از سلول های بنیادی و نانوبیوتکنولوژی در بازسازی بافت و دارو رسانی است. همچنین ایشان اخیرا در زمینه تولید پروتئین های نوترکیب فعالیت هایی را آغاز نموده اند.

    ارتباط

    رزومه

    Electrospun PCL scaffold modified with chitosan nanoparticles for enhanced bone regeneration

    Ameneh Seddighian, Fariba Ganji, Mohamadreza Baghaban-Eslaminejad, Fatemeh Bagheri
    Journal PapersProgress in Biomaterials , 2021 March 13, {Pages 12-Jan }

    Abstract

    The encapsulation of ascorbic acid within chitosan nanoparticles (CHNs), embedded in a fibrous structure of a dexamethasone (Dex)-loaded PCL scaffold, provides a new plan for osteogenic differentiation of mesenchymal stem cells. This electrospun PCL fibrous scaffold can release Dex, as bone differentiation initiator, and ascorbic acid, as bone differentiation enhancer, in an approximately sustained release pattern for about 2 weeks. Ascorbic acid-loaded CHNs were prepared by electrospraying a mixture of chitosan and ascorbic acid, and Dex-containing PCL fibers were prepared by electrospinning a mixture of PCL and Dex. The final PCL/chitosan bilayer scaffolds were obtained by the sequential employment of electrospinning and electrospraying m

    The effect of 5-fluorouracil loaded albumin magnetic nanoparticles on viability and cell cycle of human breast cancer MCF-7 cell line

    Z Rajabi, F Bagheri, SA Shojaosadati
    Journal Papers , , {Pages }

    Abstract

    Effects of Kartogenin/PLGA Nanoparticles on Silk Scaffold Properties and Stem Cell Fate

    MR Nia, F Bagheri, N Baheiraei
    Journal Papers , , {Pages }

    Abstract

    Electrospun PCL scaffold modified with chitosan nanoparticles for enhanced bone regeneration

    A Seddighian, F Ganji, M Baghaban-Eslaminejad, F Bagheri
    Journal Papers , , {Pages }

    Abstract

    Quantum dots-βcyclodextrin-histidine labeled human adipose stem cells-laden chitosan hydrogel for bone tissue engineering

    Vahid Jahed, Ebrahim Vasheghani-Farahani, Fatemeh Bagheri, Ali Zarrabi, Helene Halkj?r Jensen, Kim Lambertsen Larsen
    Journal PapersNanomedicine: Nanotechnology, Biology and Medicine , 2020 May 8, {Pages 102217 }

    Abstract

    Mesenchymal stem cells with differentiation ability to diverse cells play a crucial role in tissue engineering. Tracking the fate of these cells during the regeneration of tissue helps to obtain more information about their function. In this study, histidine conjugated β-cyclodextrin as a cell-penetrating carrier with drug loading ability was attached to QDs nanoparticle (QD-βCD-His) for stem cell labeling. Traceability of QD-βCD-His labeled human adipose stem cells (hASCs) was monitored in 2D cell culture and 3D temperature-sensitive chitosan hydrogel scaffold. Dexamethason (Dex) as an osteoinductive drug was loaded into QD-βCD-His nano-carrier (QD-βCD-His@Dex) to induce bone differentiation of labeled cells. Overall results indicated

    Physicomechanical, rheological and in vitro cytocompatibility properties of the electron beam irradiated blend hydrogels of tyramine conjugated gum tragacanth and poly (vinyl?…

    Maryam Dehghan-Niri, Ebrahim Vasheghani-Farahani, Mohamadreza Baghaban Eslaminejad, Moslem Tavakol, Fatemeh Bagheri
    Journal PapersMaterials Science and Engineering: C , 2020 May 11, {Pages 111073 }

    Abstract

    In the present study, preparation of blend hydrogels of tyramine conjugated gum tragacanth and poly (vinyl alcohol) was carried out by electron beam irradiation, and modification of hydrogel properties with poly (vinyl alcohol) was demonstrated. Gel content, swelling behavior, pore size and mechanical and rheological properties of hydrogels prepared at 14, 28 and 56 kilogray (kGy) with different ratios of polymers were investigated. Gel content increased from 67 ? 2% for pure tyramine conjugated gum tragacanth hydrogel to >92% for blend hydrogels. However, the corresponding equilibrium swelling degree decreased from 35.21 ? 1.51 to 9.14 ? 1.66 due to the higher crosslink density of blend hydrogel. The mechanical strength of the

    Self-assembled formation of chondroitin sulfate-based micellar nanogel for curcumin delivery to breast cancer cells

    Arezoo Setayesh, Fatemeh Bagheri, Soheil Boddohi
    Journal PapersInternational Journal of Biological Macromolecules , 2020 June 13, {Pages }

    Abstract

    Nanogel based drug delivery systems have been broadly used for cancer treatment. In this research, octadecylamine was grafted to chondroitin sulfate using three different mole ratios (10, 20, and 30) and named CS-ODA1, 2, and 3, respectively. The amide bond formation between chondroitin sulfate and octadecylamine was confirmed by 1H-nuclear magnetic resonance (HNMR) in the CS-ODA3 sample; therefore, further analysis was performed on this sample. Curcumin was loaded at defined Cur/CS-ODA ratios (5, 10 and 15%) and CS-ODA3 with 10% curcumin was selected for further experiments due to more entrapment efficiency (79.56% ? 5.56). In vitro release profile of the curcumin loaded nanogels showed >80% release after 70 h. In addition, the resul

    Dual functional construct containing kartogenin releasing microtissues and curcumin for cartilage regeneration

    Forogh Azam Sayahpour and Amir Mohammad Ghafari Negin Asgari , Fatemeh Bagheri, Mohamadreza Baghaban Eslaminejad, Mohammad Hossein Ghanian
    Journal PapersStem Cell Research & Therapy , Volume 11 , 2020 January , {Pages }

    Abstract

    Regeneration of articular cartilage poses a tremendous challenge due to its limited self-repair capability and inflammation at the damaged site. To generate the desired structures that mimic the structure of native tissue, microtissues with repeated functional units such as cell aggregates have been developed. Multicellular aggregates of mesenchymal stem cells (MSCs) can be used as microscale building blocks of cartilage due to their potential for cell-cell contact, cell proliferation, and differentiation. Chondrogenic microtissues were developed through incorporation of kartogenin-releasing poly (lactic-co-glycolic acid) (PLGA) microparticles (KGN-MP) within the MSC aggregates. The chondrogenic potential of KGN-MP treated MSC aggregates wa

    Inhibiting the Degeneration of Injured Cartilage Matrix by Using the RNA Interference Technology: New Horizons in Osteoarthritis Treatment

    Naghmeh Akbari Moghadam, Fatemeh Bagheri, Mohammadreza Baghaban Eslaminejad
    Journal Papers , Volume 23 , Issue 3, 2020 July 10, {Pages 0-0 }

    Abstract

    Osteoarthritis is the most common articular disease that has significantly affected the patients’ quality of life. As cartilage doesn’t have any blood vessels and neurons, its treatment is a difficult task to do. Traditional therapeutic approaches, including the use of non-steroidal anti-inflammatory drugs (NSAIDs) and surgical interventions, can only control the disease, and the joint will lose its functionality after a short period. Consequently, modern methods such as cell therapy and tissue engineering along with using various biomaterials are being attempted to repair degenerated cartilage tissue. Using interfering RNAs is another approach that targets specific destructive or malfunctioned RNA sequences and suppresses the responsib

    Physicomechanical, rheological and in vitro cytocompatibility properties of the electron beam irradiated blend hydrogels of tyramine conjugated gum tragacanth and poly (vinyl …

    M Dehghan-Niri, E Vasheghani-Farahani, MB Eslaminejad, M Tavakol, ...
    Journal Papers , , {Pages }

    Abstract

    The effect of modified electrospun PCL‐nHA‐nZnO scaffolds on osteogenesis and angiogenesis

    Amin Rahmani, Sameereh Hashemi‐Najafabadi, Mohamadreza Baghaban Eslaminejad, Fatemeh Bagheri, Forough Azam Sayahpour
    Journal PapersJournal of Biomedical Materials Research Part A , 2019 May 11, {Pages }

    Abstract

    Large bone defects treatment is one of the challenges in current bone tissue engineering approaches. Various strategies have been proposed to address this issue, among which, pre‐vascularization by co‐culturing of angiogenic and osteogenic cells on the scaffolds can alleviate this problem. In the present study, modified fibrous scaffolds were prepared by electrospinning and subsequent ultrasonication of polycaprolactone (PCL) containing nano‐hydroxyapatite (n‐HA), with/without nano‐zinc oxide (n‐ZnO), and polyethylene oxide (PEO) as a sacrificial agent. The physical, mechanical and chemical characteristics of the scaffolds were evaluated. The results showed the presence of n‐ZnO, which in turn increased Young's module of the

    A benchmark-driven approach to reconstruct metabolic networks for studying cancer metabolism

    Oveis Jamialahmadi, Sameereh Hashemi-Najafabadi, Ehsan Motamedian, Stefano Romeo, Fatemeh Bagheri
    Journal PapersPLOS Computational Biology , Volume 15 , Issue 4, 2019 April 22, {Pages e1006936 }

    Abstract

    Genome-scale metabolic modeling has emerged as a promising way to study the metabolic alterations underlying cancer by identifying novel drug targets and biomarkers. To date, several computational methods have been developed to integrate high-throughput data with existing human metabolic reconstructions to generate context-specific cancer metabolic models. Despite a number of studies focusing on benchmarking the context-specific algorithms, no quantitative assessment has been made to compare the predictive performance of these methods. Here, we integrated various and different datasets used in previous works to design a quantitative platform to examine functional and consistency performance of several existing genome-scale cancer modeling a

    Surface engineering of titanium-based implants using electrospraying and dip coating methods

    Akbar Javadi, Atefeh Solouk, Masoumeh Haghbin Nazarpak, Fatemeh Bagheri
    Journal PapersMaterials Science and Engineering: C , Volume 99 , 2019 January 25, {Pages 620-630 }

    Abstract

    Titanium and its alloys due to their low density, good mechanical and biological properties are of the most common orthopedic metals. One of the main challenges regarding to titanium implants is their loosening after long term implantation in patient's body. Many methods such as alteration in surface topography with focus on improving osseointegration or biocompatibility in overall are supposed to overcome this issue. In this research, titanium surface topography is altered via electrospraying a solution of titanium salt, carrier polymer (polyvinylpyrrolidone) and solvents. The dip coated samples in the same solution are prepared and investigated as control. The electrosprayed or dip coated samples were pyrolysised in furnace at 500 ?C to

    Efficacy of mechanical vibration in regulating mesenchymal stem cells gene expression

    Frough Azam Sayahpour Atiyeh Sadat Safavi, Gholamreza Rouhi, Nooshin Haghighipour,Fatemeh Bagheri,Mohamadreza Baghaban Eslaminejad
    Journal PapersIn Vitro Cellular & Developmental Biology - Animal , Volume 55 , 2019 January , {Pages 387–394 }

    Abstract

    This study aimed at investigating the expression of osteoblast and chondrocyte-related genes in mesenchymal stem cells (MSCs), derived from rabbit adipose tissue, under mechanical vibration. The cells were placed securely on a vibrator’s platform and subjected to 300 Hz of sinusoidal vibration, with a maximum amplitude of 10 μm, for 45 min per day, and for 14 consequent days, in the absence of biochemical reagents. The negative control group was placed in the conventional culture medium with no mechanical loading. The expression of osteoblast and chondrocyte-related genes was investigated using real-time polymerase chain reaction (real-time PCR). In addition, F-actin fiber structure and alignment with the help of actin filament fluoresce

    Preparation and Characterization of Nanocomposite Scaffolds (Collagen/β-TCP/SrO) for Bone Tissue Engineering

    Hamid Goodarzi, Sameereh Hashemi-Najafabadi, Nafiseh Baheiraei, Fatemeh Bagheri
    Journal PapersTissue Engineering and Regenerative Medicine , 2019 January , {Pages 15-Jan }

    Abstract

    Background:Nowadays, production of nanocomposite scaffolds based on natural biopolymer, bioceramic, and metal ions is a growing field of research due to the potential for bone tissue engineering applications.Methods:In this study, a nanocomposite scaffold for bone tissue engineering was successfully prepared using collagen (COL), beta-tricalcium phosphate (β-TCP) and strontium oxide (SrO). A composition of β-TCP (4.9 g) was prepared by doping with SrO (0.05 g). Biocompatible porous nanocomposite scaffolds were prepared by freeze-drying in different formulations [COL, COL/β-TCP (1: 2 w/w), and COL/β-TCP-Sr (1: 2 w/w)] to be used as a provisional matrix or scaffold for bone tissue engineering. The nanoparticles were characterized by X-ray

    Enhanced Cellular Uptake Of Phenamil Through Inclusion Complex With Histidine Functionalized β-Cyclodextrin As Penetrative Osteoinductive Agent

    Kim Lambertsen Larsen Vahid Jahed,Ebrahim Vasheghani-Farahani,Fatemeh Bagheri, Ali Zarrabi,Trine Fink
    Journal PapersInternational Journal of Nanomedicine , Volume 14 , 2019 January , {Pages 8221–8234 }

    Abstract

    BackgroundPhenamil (PH) is a small molecule that induces bone formation through upregulation of the TRB3 gene in the bone-regeneration process. β-Cyclodextrins (βCDs) with hydrophilic surfaces and a relatively hydrophobic cavity can form inclusion complexes with primarily hydrophobic small molecules such as PH, and increase their apparent solubility and dissolution rate. The hydrophilic surface of βCDs prevents their interaction with the hydrophobic lipids of the cell membrane for penetration. Therefore, binding of penetrative groups, such as lysine, arginine, and histidine (His), to βCDs for cell penetration is required.AimThe aim of this study was to investigate the effect of His-conjugated βCD on cellular uptake of PH for bone diffe

    Scalable and cost-effective generation of osteogenic micro-tissues through incorporation of inorganic microparticles within mesenchymal stem cell spheroids

    Ibrahim Zarkesh, Majid Halvaei, Mohammad Hossein Ghanian, Fatemeh Bagheri, Forough Azam Sayahpour, Mahmoud Azami, Javad Mohammadi, Hossein Baharvand, Mohamadreza Baghaban Eslaminejad
    Journal PapersBiofabrication , 2019 October 28, {Pages }

    Abstract

    Mesenchymal stem cells (MSCs) are considered primary candidates for treating complex bone defects in cell-based therapy and tissue engineering. Compared with monolayer cultures, spheroid cultures of MSCs (mesenspheres) are favorable due to their increased potential for differentiation, extracellular matrix (ECM) synthesis, paracrine activity, and in vivo engraftment. Here, we present a microparticle incorporation strategy for fabrication of osteognic microtissues from mesenspheres in a cost-effective and scalable manner. A facile method was developed to synthesize mineral microparticles with cell-sized spherical shape, biphasic calcium posphate composition (hydroxyaptite and β-tricalcium phosphate), and a microporous structure. The calcium

    Optimization and characterization of Aspirin Encapsulated nano-Liposomes

    Samira Khodayar, Hassan Bardania, Seyed Abbas Shojaosadati, Fatemeh Bagheri
    Journal PapersIranian journal of pharmaceutical research: IJPR , Volume 17 , Issue 1, 2018 January , {Pages 22-Nov }

    Abstract

    Resistance to aspirin and its cytotoxicity significantly limits its therapeutic applications. Nano-liposomal encapsulation of aspirin can reduce its cytotoxicity. In this study, aspirin encapsulating nano-liposomes (AS-NL) was prepared and its performance in drug delivery and also cytotoxicity was evaluated. The effects of two independent variables including number of freeze/thawing cycles and concentration of aspirin on encapsulation efficiency was investigated using response surface methodology (RSM). A drug profile release was obtained by AS-NL. The concentration of cholesterol as effective for liposome stability and sodium lauryl sulfate (SLS) as a drug release facilitator was also optimized using RSM. The maximum aspirin encapsulation

    Immunoisolation of stem cells by simultaneous encapsulation and PEGylation

    Roya Ramezanzadeh Andevari, Sameereh Hashemi-Najafabadi, Fatemeh Bagheri
    Journal PapersProgress in biomaterials , Volume 7 , Issue 1, 2018 March 1, {Pages 55-60 }

    Abstract

    Today, cell therapy is known as an important tool in the treatment of chronic diseases where cells lose their normal function. Immunoisolation systems using microencapsulation or PEGylation have been developed to evade the problem of rejection by the immune system. The aim of the present study was to investigate a combination of microencapsulation and PEGylation methods in coating mouse embryonic stem cells (mESCs) to determine its effect in reducing the host’s immune response. Therefore, methoxy polyethylene glycol (mPEG) binding on alginate–trimethyl chitosan (TMC) microcapsules was investigated using FTIR. Furthermore, survival of the microencapsulated mESCs was confirmed using AO/PI staining and MTT assays. In addition,

    New Insight into Functional Limb Regeneration: A to Z Approaches

    Leila Taghiyar, Samaneh Hosseini, Fatemeh Safari, Fatemeh Bagheri, Nesa Fani, Martin J Stoddart, Mauro Alini, Mohamadreza Baghaban Eslaminejad
    Journal PapersJournal of tissue engineering and regenerative medicine , Volume 12 , Issue 9, 2018 July 16, {Pages 1925-1943 }

    Abstract

    Limb/digit amputation is a common event in humans caused by trauma, medical illness, or surgery. Although the loss of a digit is not lethal, it affects quality of life and imposes high costs on amputees. In recent years, the increasing interest in limb regeneration has led to enhanced scientific knowledge. However, the limited ability to develop functional limb regeneration in the clinical setting suggests that a challenging issue remains in limb regeneration. Recently, the emergence of regenerative engineering is a promising field to address this challenge and close the gap between science and clinical applications. Cell signalling and molecular mechanisms involved in the limb regeneration process have been extensively studied; however, t

    دروس نیمسال جاری

    • دكتري
      مهندسي ژنتيك ( واحد)
      دانشکده مهندسی شیمی، گروه مهندسي شيمي - بيوتكنولوژي
    • كارشناسي ارشد
      تنظيم اپي ژنتيك سلولهاي بنيادي ( واحد)

    دروس نیمسال قبل

    • كارشناسي ارشد
      بيوشيمي عمومي ( واحد)
      دانشکده مهندسی شیمی، گروه مهندسي شيمي - بيوتكنولوژي
    • كارشناسي ارشد
      ايمونولوژي عمومي ( واحد)
    • كارشناسي ارشد
      ايمونولوژي عمومي ( واحد)
    • كارشناسي ارشد
      فيزيولوژي و آناتومي ( واحد)
    • كارشناسي ارشد
      آزمايشگاه كشت بافت ( واحد)
    • كارشناسي ارشد
      آزمايشگاه كشت بافت ( واحد)
    • 1397
      بهراميان, نگار
      طراحي سيستم دارورسان هدفمند حساس به pH بر پايه ي نانوذرات ابريشم-كيتوسان حامل داروي ضد سرطان
    • 1397
      مهبودي, فرشاد
    • 1397
      نوروزي, فاطمه
    • 1397
      وفاپور, فاطمه
    • 1398
      صمدي, زهره
    • 1398
      ناظم الرعايا, مريم
    • 1398
      احمدي اصل, اميررضا
    • 1397
      صعودي, طوبي
      استفاده از سامانه ليپوزومي هدفمند براي انتقال همزمان دو داروي متابوليكي ضدسرطان
      داده ای یافت نشد
      داده ای یافت نشد
      داده ای یافت نشد
    • دانشجوی ممتاز
    • رتبه اول در آزمون ورودی در مقطع دکتری
    • رتبه اول در مقطع کارشناسي
    • رتبه اول در مقطع کارشناسي ارشد
    • دریافت گرنت برای شرکت در کارگاه “Bioinformatics Approaches for Analysis of High-throughput Biological Data” ،Istanbul Bilgi University, Istanbul, Turkey از طرف مرکز بین المللی ICGEB(International Center for Genetic Engineering and Biotechnology)

    مهم

    جدید

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