En
  • دکتری (1384)

    مهندسی شیمی - بیوتکنولوژی

    دانشگاه تربیت مدرس،

  • کارشناسی‌ارشد (1378)

    مهندسی شیمی - بیوتکنولوژی

    دانشگاه تربیت مدرس،

  • کارشناسی (1375)

    مهندسی شیمی - صنایع پتروشیمی

    دانشگاه صنعتی امیرکبیر،

  • مهندسی بافت
  • سلول درمانی
  • آزمایشگاه مهندسی بافت و دارورسانی

    زمینه های پژوهشی:

    کارشناس مسئول:

    تلفن:

    مکان: جلال آل احمد-دانشگاه تربیت مدرس-دانشکده فنی مهندسی-طبقه منفی 1-اتاق 25/2-4

دکتر سمیره هاشمی نجف آبادی، دانشیار گروه مهندسی زیست پزشکی. اخذ مدرک کارشناسی مهندسی شیمی- پتروشیمی: دانشگاه صنعتی امیرکبیر، تهران، 1375. اخذ مدرک کارشناسی ارشد مهندسی شیمی- بیوتکنولوژی: دانشگاه تربیت مدرس، تهران، 1378. اخذ مدرک دکتری مهندسی شیمی- بیوتکنولوژی: دانشگاه تربیت مدرس، تهران، 1384. دوره فرصت مطالعاتی دوره دکتری: دانشگاه کیوتو، ژاپن. زمینه های تحقیقاتی: مهندسی بافت، سلول درمانی، مینی بیوراکتورها

ارتباط

رزومه

Surface Modification of Electrospun Wound Dressing Material by Fe2O3 Nanoparticles Incorporating Lactobacillus Strains for Enhanced Antimicrobial and Antibiofilm Activity

FN Harandi, AC Khorasani, SA Shojaosadati, S Hashemi-Najafabadi
Journal Papers , , {Pages }

Abstract

Living Lactobacillus–ZnO nanoparticles hybrids as antimicrobial and antibiofilm coatings for wound dressing application

FN Harandi, AC Khorasani, SA Shojaosadati, S Hashemi-Najafabadi
Journal Papers , , {Pages }

Abstract

High cell density culture of recombinant E. coli in the miniaturized bubble columns

S Khanchezar, S Hashemi-Najafabadi, SA Shojaosadati, V Babaeipour
Journal Papers , , {Pages }

Abstract

Indirect Tumor Inhibitory Effects of MicroRNA-124 through Targeting EZH2 in The Multiple Myeloma Cell Line

Javid Sabour Takanlu, Arad Aghaie Fard, Saeed Mohammdi, Mohsen Nikbakht, Negin Afrang, Rezvan Tavakoli, Nooshin Tasharrofi, Fatemeh Kouhkan, Farnaz Razmkhah, Sorayya Ghasemi, Masoud Soleimani, Sedigheh Amini Kafi-abad, Arezou Mehrabi, Nafiseh Baheiraei, M
Journal PapersCell Journal (Yakhteh) , Volume 22 , Issue 1, 2020 March 1, {Pages }

Abstract

Objective: Multiple myeloma (MM) is an incurable plasma cell malignancy. Several genetic and epigenetic changes affect numerous critical genes expression status in this disorder. CDKN2A gene is expressed at low level in almost all cases with MM disease. The mechanism of this gene down-regulation has remained controversial. In the present study, we targeted EZH2 by microRNA-124 (miR-124) in L-363 cells and assessed following possible impact on CDKN2A gene expression and phenotypic changes.Materials and Methods: In this experimental study, growth inhibitory effects of miR-124 were measured by MTT assay in L-363 cell line. Likewise, cell cycle assay was measured by flowcytometery. The expression levels of EZH2 and CDKN2A were evaluated by real

Synthesis and characterization of antimicrobial wound dressing material based on silver nanoparticles loaded gum Arabic nanofibers

Naeimeh Eghbalifam, Seyed Abbas Shojaosadati, Sameereh Hashemi-Najafabadi, Alireza Chackoshian Khorasani
Journal PapersInternational Journal of Biological Macromolecules , 2020 March 26, {Pages }

Abstract

Gum Arabic (GA) is a biocompatible polymer with the necessary requirements for a wound dressing. However, electrospinning of GA is a bottleneck due to its physico-chemical properties. The aim of this study was to fabricate an antimicrobial nanofibers mat from GA with suitable porosity, water absorption, water vapor permeability and mechanical strength. For this purpose, the composition of polycaprolacton (PCL)-coated GA-polyvinyl alcohol (PVA) nanofibers mat was optimized based on the possible highest porosity, water absorption and water vapor permeability, and then silver nanoparticles (AgNPs) loaded nanofibers mat was prepared based on this composition. The synthesis of AgNPs was supported by UV–vis and ICP analyses. The structure of ma

The effect of modified electrospun PCL‐nHA‐nZnO scaffolds on osteogenesis and angiogenesis

Amin Rahmani, Sameereh Hashemi‐Najafabadi, Mohamadreza Baghaban Eslaminejad, Fatemeh Bagheri, Forough Azam Sayahpour
Journal PapersJournal of Biomedical Materials Research Part A , 2019 May 11, {Pages }

Abstract

Large bone defects treatment is one of the challenges in current bone tissue engineering approaches. Various strategies have been proposed to address this issue, among which, pre‐vascularization by co‐culturing of angiogenic and osteogenic cells on the scaffolds can alleviate this problem. In the present study, modified fibrous scaffolds were prepared by electrospinning and subsequent ultrasonication of polycaprolactone (PCL) containing nano‐hydroxyapatite (n‐HA), with/without nano‐zinc oxide (n‐ZnO), and polyethylene oxide (PEO) as a sacrificial agent. The physical, mechanical and chemical characteristics of the scaffolds were evaluated. The results showed the presence of n‐ZnO, which in turn increased Young's module of the

Osteogenic induction of human mesenchymal stem cells in multilayered electrospun scaffolds at different flow rates and configurations in a perfusion bioreactor

Maliheh Yaghoobi, Sameereh Hashemi-Najafabadi, Masoud Soleimani, Ebrahim Vasheghani-Farahani
Journal PapersJournal of bioscience and bioengineering , 2019 May 10, {Pages }

Abstract

Electrospun scaffolds are potentially interesting in bone tissue engineering due to a strong structural similarity to the natural bone matrix. To investigate the osteogenic behavior of cells on the scaffolds, dynamic culture of cells is essential to simulate the biological environment. In the present study, human mesenchymal stem cells (hMSCs) were cultured on multilayer nanohydroxyapatite-polycaprolactone electrospun scaffolds at different configurations (horizontal with or without pressure and parallel with the medium flow) and flow rates in a perfusion bioreactor. Alkaline phosphatase (ALP) activity, cell viability, Ca deposition and RUNX2 expression were determined in three different dynamic states, and compared with static culture afte

A benchmark-driven approach to reconstruct metabolic networks for studying cancer metabolism

Oveis Jamialahmadi, Sameereh Hashemi-Najafabadi, Ehsan Motamedian, Stefano Romeo, Fatemeh Bagheri
Journal PapersPLoS computational biology , Volume 15 , Issue 4, 2019 April 22, {Pages e1006936 }

Abstract

Genome-scale metabolic modeling has emerged as a promising way to study the metabolic alterations underlying cancer by identifying novel drug targets and biomarkers. To date, several computational methods have been developed to integrate high-throughput data with existing human metabolic reconstructions to generate context-specific cancer metabolic models. Despite a number of studies focusing on benchmarking the context-specific algorithms, no quantitative assessment has been made to compare the predictive performance of these methods. Here, we integrated various and different datasets used in previous works to design a quantitative platform to examine functional and consistency performance of several existing genome-scale cancer modeling a

Preparation and Characterization of Nanocomposite Scaffolds (Collagen/β-TCP/SrO) for Bone Tissue Engineering

Hamid Goodarzi, Sameereh Hashemi-Najafabadi, Nafiseh Baheiraei, Fatemeh Bagheri
Journal PapersTissue engineering and regenerative medicine , 2019 June 1, {Pages 15-Jan }

Abstract

Background:Nowadays, production of nanocomposite scaffolds based on natural biopolymer, bioceramic, and metal ions is a growing field of research due to the potential for bone tissue engineering applications.Methods:In this study, a nanocomposite scaffold for bone tissue engineering was successfully prepared using collagen (COL), beta-tricalcium phosphate (β-TCP) and strontium oxide (SrO). A composition of β-TCP (4.9 g) was prepared by doping with SrO (0.05 g). Biocompatible porous nanocomposite scaffolds were prepared by freeze-drying in different formulations [COL, COL/β-TCP (1: 2 w/w), and COL/β-TCP-Sr (1: 2 w/w)] to be used as a provisional matrix or scaffold for bone tissue engineering. The nanoparticles were characterized by X-ray

Preparation of an enzyme catalyzed in situ forming hydrogel based on chemically modified tragacanth for cartilage tissue engineering

Moslem Tavakol, Ebrahim Vasheghani-Farahani, Masoud Soleimani, Sameereh Hashemi-Najafabadi, Atena Hajizadeh
Journal PapersJournal of Cellular and Molecular Research (Iranian Journal of Biology) , Volume 32 , Issue 3, 2019 October 23, {Pages 292-304 }

Abstract

In the present study, an enzyme catalyzed in situ forming hydrogel based on chemically modified tragacanth was prepared and then evaluated for use in cartilage tissue engineering. For this purpose, firstly tyramine was conjugated on the galacturonic acid methyl ester units of gum tragacanth (GT) via ammonolysis of methyl ester groups in heterogeneous media. Then, the hydrogel was prepared by mixing of functionalized polymer, horseradish peroxidase (HRP) and hydrogen peroxide using a double syringe equipped with a mixing chamber. Then, cell viability of the encapsulated human mesenchymal stem cells (hMSCs) and in vitro chondrocyte differentiation of them, incubated in the presence of differentiation medium, were investigated. After mixing of

Preparation and Investigation of the Effect of Alginate Nanoparticles Coated by Trimethylchitosan (TMC) and Polyethylene Glycol (PEG) for Oral Delivery of Insulin

S Komijani, S Hashemi Najafabadi, M Rafiee Tehrani
Journal Papers , , {Pages }

Abstract

Immunoisolation of stem cells by simultaneous encapsulation and PEGylation

Roya Ramezanzadeh Andevari, Sameereh Hashemi-Najafabadi, Fatemeh Bagheri
Journal PapersProgress in biomaterials , Volume 7 , Issue 1, 2018 March 1, {Pages 55-60 }

Abstract

Today, cell therapy is known as an important tool in the treatment of chronic diseases where cells lose their normal function. Immunoisolation systems using microencapsulation or PEGylation have been developed to evade the problem of rejection by the immune system. The aim of the present study was to investigate a combination of microencapsulation and PEGylation methods in coating mouse embryonic stem cells (mESCs) to determine its effect in reducing the host’s immune response. Therefore, methoxy polyethylene glycol (mPEG) binding on alginate–trimethyl chitosan (TMC) microcapsules was investigated using FTIR. Furthermore, survival of the microencapsulated mESCs was confirmed using AO/PI staining and MTT assays. In addition,

Determination of Biological Activity of Recombinant Reteplase Using Clot Lysis Time and Activated Partial Thromboplastin Time (APTT) Lysis Methods: A Comparative Study

Tahereh Babaee, Ahmad Fazeli, Sameereh Hashemi-Najafabadi, Hosein Rastegar, Ali Mohammadi, Mohammad Reza Khoshayand, Mahmoud Alebouyeh, Mohammad Reza Fazeli
Journal PapersIranian journal of pharmaceutical research: IJPR , Volume 17 , Issue 4, 2018 January , {Pages 1503 }

Abstract

Recombinant plasminogen activator (reteplase) is a third generation thrombolytic agent which has been used on coronary artery thrombosis and acute myocardial infarction. Clot lysis assay is usually considered as a unique method to evaluate biological activity of reteplase. In this study biological activity of reteplase was determined by APTT (activated partial thromboplastin time) lysis method. Validity of this method was evaluated in comparison with reference method, clot lysis time assay. Results of APTT lysis test showed good reproducibility (relative standard deviation (RSD) 3-5% for within day analysis and 4-7% for between day analysis), and accuracy (101.3-102.7%). APTT lysis responses were linear in range of 0.001-0.1 mg/mL reteplase

Self-assembled and pH-sensitive mixed micelles as an intracellular doxorubicin delivery system

Samira Jafarzadeh-Holagh, Sameereh Hashemi-Najafabadi, Hossein Shaki, Ebrahim Vasheghani-Farahani
Journal PapersJournal of colloid and interface science , Volume 523 , 2018 August 1, {Pages 179-190 }

Abstract

Nanocarrier-based drug delivery systems have been explored extensively in cancer therapy. Among the vast number of different nanocarrier systems applied to deliver chemotherapeutics to cancer tumor, intelligent systems which deliver drug to various sites in the body have attracted considerable attentions. Finding a specific stimulant that triggers the carrier to release its payload in the target tissue is a key parameter for efficacy of delivery systems. Acidic pH of cancer tumor helps a pH-sensitive carrier to release drug at the tumor site. In this study, a pH-sensitive mixed micellar system was developed using Dextran-Stearic Acid (Dex-SA) and Dextran-Histidine (Dex-His) conjugated polymers to deliver doxorubicin (DOX) to cancer cells. D

Hydrodynamics and mass transfer in miniaturized bubble column bioreactors

Sirwan Khanchezar, Sameereh Hashemi-Najafabadi, Seyed Abbas Shojaosadati, Valiollah Babaeipour
Journal PapersBioprocess and biosystems engineering , 2018 October 25, {Pages 10-Jan }

Abstract

Miniaturized bubble columns (MBCs) have different hydrodynamics in comparison with the larger ones, but there is a lack of scientific data on MBCs. Hence, in this study, the effect of gas hold-up, flow regimes, bubble size distribution on volumetric oxygen mass transfer coefficient at different pore size spargers and gas flow rates in MBCs in the presence and absence of microorganisms were investigated. It was found that flow regime transition occurred around low gas flow rates of 1.18 and 0.85 cm/s for small (16–40 ?m) and large (40–100 ?m) pore size spargers, respectively. Gas hold-up and K L a in MBC with small size sparger were higher than those with larger one, with an increasing effect in the presence of microorganisms. A comparis

Normal nsulin Secretion from the Immune-protected Islets of Langerhans by PEGylation and Encapsulation in the Alginate-chitosan-PEG

Nahid Najafikhah, Sameereh Hashemi-Najafabadi, Saleh Zahediasl, Mohammad Mahdi Nabavimanesh, Khadijeh Farrokhfall
Journal PapersIranian Journal of Biotechnology , Volume 16 , Issue 4, 2018 December 12, {Pages 258-263 }

Abstract

Background: Pancreatic islet transplantation is one of the most promising strategies for treating patients with type I diabetes mellitus.Objective: We aimed to assess the immunoisolation properties of the multilayer encapsulated islets using alginate-chitosan-PEG for immunoprotection and insulin secretion from the encapsulated islets induced under different glucose concentrations in vitro.Materials and Methods: In this study, the islets were isolated from Wistar rats. The biological function (insulin secretion) of the immunoisolated islets following to PEGylation and encapsulation in the alginate-chitosan-PEG, separately, in addition to their immuno-protection in a co-culturing with the lymphocytes isolated from the male C57BL/6 mice were i

Normal Insulin Secretion from Immune-Protected Islets of Langerhans by PEGylation and Encapsulation in the Alginate-Chitosan-PEG

N Najafikhah, S Hashemi-Najafabadi, S Zahediasl, MM Nabavimanesh, ...
Journal Papers , , {Pages }

Abstract

Cell laden hydrogel construct on-a-chip for mimicry of cardiac tissue in-vitro study

Ali Ghiaseddin, Hossein Pouri, Masoud Soleimani, Ebrahim Vasheghani-Farahani, Hossein Ahmadi Tafti, Sameereh Hashemi-Najafabadi
Journal PapersBiochemical and biophysical research communications , Volume 484 , Issue 2, 2017 March 4, {Pages 225-230 }

Abstract

Since the leading cause of death are cardiac diseases, engineered heart tissue (EHT) is one of the most appealing topics defined in tissue engineering and regenerative medicine fields. The importance of EHT is not only for heart regeneration but also for in?vitro developing of cardiology. Cardiomyocytes could grow and commit more naturally in their microenvironment rather than traditional cultivation. Thus, this research tried to develop a set up on-a-chip to produce EHT based on chitosan hydrogel.Micro-bioreactor was hydrodynamically designed and simulated by COMSOL and produced via soft lithography process. Chitosan hydrogel was also prepared, adjusted, and assessed by XRD, FTIR and also its degradation rate and swelling ratio were determ

The effect of increasing the pore size of nanofibrous scaffolds on the osteogenic cell culture using a combination of sacrificial agent electrospinning and ultrasonication

Mahdiyeh Aghajanpoor, Sameereh Hashemi‐Najafabadi, Mohamadreza Baghaban‐Eslaminejad, Fatemeh Bagheri, Seyyed Mohammad Mousavi, Foruogh Azam Sayyahpour
Journal PapersJournal of Biomedical Materials Research Part A , Volume 105 , Issue 7, 2017 July , {Pages 1887-1899 }

Abstract

One of the major problems associated with the electrospun scaffolds is their small pore size, which limits the cellular infiltration for bone tissue engineering. In this study, the effect of increasing the pore size on cellular infiltration was studied in poly/nanohydroxyapatite electrospun scaffolds, which were modified using ultrasonication, co‐electrospinning with poly (ethylene oxide), and a combination of both. Ultrasonic process was optimized by central composite design. The ultrasonic output power and time of the process were considered as the effective parameters. The pore size of the scaffolds was evaluated by scanning electron microscope. The optimum conditions, according to the pore area and mechanical properties of the scaffo

Synergistic effect of PEGylation and pentoxifylline addition on immunoprotection of pancreatic islets

Javad Hashemi, Sameereh Hashemi-Najafabadi, Ebrahim Vasheghani-Farahani
Journal PapersJournal of Biomaterials science, Polymer edition , Volume 28 , Issue 1, 2017 January 2, {Pages 33-49 }

Abstract

In this study, a method is proposed to reduce immunological response of immune system against Langerhans islets by PEGylation of islets combined with adjuvant therapy. For this purpose, the best composition for a mixture of succinimidyl valeric acid activated mPEG (mPEG-SVA) with different molecular weights (MWs) and for a mixture of succinimidyl carbonate activated mPEG (mPEG-SC) with different MWs was determined separately. Then, the effect of pentoxifylline (PTX) as an adjuvant drug on immunological response against PEGylated islets at best mPEG composition was studied. The extent of mPEGs reaction, the amount of interlukin-2 (IL-2) and perforin secretion, and the viability of lymphocytes and islets in homo and co-cultures in the presenc

دروس نیمسال جاری

  • كارشناسي ارشد
    مهندسي بافت ( واحد)
    دانشکده مهندسی شیمی، گروه مهندسي شيمي - زيست پزشكي

دروس نیمسال قبل

  • كارشناسي ارشد
    بيو راكتور ( واحد)
    دانشکده مهندسی شیمی، گروه مهندسي شيمي - زيست پزشكي
  • 1397
    عابدي درچه, كيوان
    بررسي كارايي ريزپوشينه دارهاي هسته-پوسته چندلايه با هسته مايع يا نيمه مايع براي سلول درماني
  • 1397
    كاظميان نجف ابادي, زهرا
  • 1398
    دبيري سطري, مريم
  • 1398
    قاسمي, زهرا
  • 1395
    مقدم ديمه, سعيد
    بررسي همزمان استخوان زايي و رگ زايي روي داربست هاي چند لايه اي الكتروريسي شده (با اصلاح اندازه منافذ) در زيست واكنش گاه جريان اجباري
  • 1396
    مهدوي, رضا
  • - مدیر گروه بیوتکنولوژی و زیست پزشکی: اردیبهشت 90 تا مهر 94
  • - معاون پژوهشی دانشکده مهندسی شیمی: مهر 94 تا مهر 96
  • - مدیر گروه زیست پزشکی: شهریور 97 تاکنون
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