Fa
  • Ph.D. (1983)

    Human Genetics

    , Newcastle, England

  • Molecular methods in diagnosing genetic diseases and cancers
  • Gene therapy in genetic diseases and cancers

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    Curriculum Vitae (CV)

    Investigation the Role of Autophagy in Non-Small Cell Lung Cancer

    Minoo Pargol, Shima Zare Karizi, Masoumeh Akbari, Bahareh Nourmohammadi, Mohammad Behgam Shadmehr, Morteza Karimipoor, Shohreh Zare Karizi
    Journal PaperAsian Pacific Journal of Cancer Prevention: APJCP , Volume 22 , Issue 3, 2021 March 1, {Pages 947-955 }

    Abstract

    Objective: Recent studies have shown the role of autophagy in different types of cancer including lung cancer. MicroRNAs are considered as key factors in regulation of autophagy related genes. miR-30d, miR-204-5p and miR-20a are regulatory markers which can suppress the expression of beclin1, LC3, bcl2 and ULK1 as their target genes and they lead to decrement of autophagy in human cancer cells. Moreover, epigenetic modifications DNA methylation has been indicated in regulation of autophagy in different stages of cancer. Methods: In this study, the expression levels of miR-30d, miR-204-5p and miR-20a as well as their target genes were analyzed in 30 non-small cell lung cancers (NSCLCs) patients sample and adjacent normal tissues by real-time

    Distribution of HLA Alleles and Genotypes in Patients with Chronic Inflammatory Demyelinating Polyneuropathy

    S Ghafouri-Fard, MT Akbari, H Houlden, M Mazdeh, N Nazer, O Rezaei, ...
    Journal Paper , , {Pages }

    Abstract

    Assessment of DAPK1 and CAVIN3 Gene Promoter Methylation in Breast Invasive Ductal Carcinoma and Metastasis

    E Ghalkhani, MT Akbari, P Izadi, H Mahmoodzadeh, F Kamali
    Journal Paper , , {Pages }

    Abstract

    Intrathecal administration of the extracellular vesicles derived from human Wharton’s jelly stem cells inhibit inflammation and attenuate the activity of inflammasome complexes …

    L Noori, S Arabzadeh, Y Mohamadi, S Mojaverrostami, T Mokhtari, ...
    Journal Paper , , {Pages }

    Abstract

    The Right to be Represented in Court by a Lawyer to the Judiciary in the Iranian LAW and Supranational Trial

    H Abhari, M Pakzad, M Akbari, MT Ghaffari
    Journal Paper , , {Pages }

    Abstract

    A New Feature Selection-Aided Observer for Sensor Fault Diagnosis of an Industrial Gas Turbine

    M Akbari, AM Khoshnood
    Journal Paper , , {Pages }

    Abstract

    Assessment of FMR1 triplet repeats in patients affected with mental retardation, fragile X syndrome and primary ovarian insufficiency

    Zeinab Salimy, Mohammad Taghi Akbari, Faravareh Khordadpoor Deilamani
    Journal PaperJournal of Genetics , Volume 99 , Issue 1, 2020 December , {Pages 05-Jan }

    Abstract

    The CGG repeats in the FMR1 gene expand in patients with fragile X syndrome, fragile X-associated tremour/ataxia syndrome and fragile X-associated primary ovarian failure. In this study, the CGG repeats in the FMR1 gene were studied in 449 males and 207 females using traditional polymerase chain reaction and triplet repeat primed PCR methods, also 18 CVS samples (six males and 12 females) were tested for prenatal diagnosis. Further, methylation sensitive multiplexed ligation dependent probe amplification was performed on some samples to confirm the results. Regarding the male patients, 1.1% and 9.7% had premutation (PM) and full mutation (FM) alleles, respectively. Also three (0.66%) male patients were mosaic for PM and FM alleles. Among fe

    Identification of a Mutation in SPG11 in an Iranian Patient with Spastic Paraplegia and Ears of the Lynx Sign

    Arezou Sayad, Mohammad Taghi Akbari, Omid Hesami, Soudeh Ghafouri-Fard, Mohammad Taheri
    Journal PaperJournal of Molecular Neuroscience , 2020 February 10, {Pages 03-Jan }

    Abstract

    Hereditary spastic paraplegia (HSP) includes a number of inherited disorders which are characterized by stiffness in the lower extremities and progressive gait disturbance. Mutations in terms of spastic gait genes (SPGs) are responsible for occurrence of different types of HPS with autosomal recessive, X-linked recessive, and autosomal dominant modes of inheritance. In the current case report, we identified a mutation in SPG11 gene in a female patient with progressive stiffness of lower extremities and atrophy of corpus callosum and the “lynx ear” sign in brain MRI. Whole exome sequencing (WES) revealed a homozygote frameshift deletion variant in SPG11 gene (NM001160227: exon 28: c. 4746delT, p. N1583Tfs* 23). This variant is a null var

    The Effectiveness of Integrative Acceptance Commitment-Cognitive Behavioral Therapy (ACT-CBT) and Parent Management Training (PMT) on the Post Traumatic Stress Disorder?…

    Mohammad Akbari, Mohsen Golparvar, Mohsen Lali
    Journal PaperJournal of Research in Behavioural Sciences , Volume 18 , Issue 1, 2020 March 10, {Pages 0-0 }

    Abstract

    Objective: Sexual abuse of children and adolescences is a global phenomenon. These behaviors have a destructive effect on the mental health of adolescents. The aim of this study was to determine the effectiveness of ACT-CBT therapy and parent management training (PMT) on the post-traumatic stress disorder symptoms of adolescent boy with sexual abuse.Methods: The research method was semi-experimental, and research design was three groups (one group ACT-CBT therapy, one group PMT and one group of control) with three stages of pre-test, post-test and two months follow-up. Among fifty 14-18 years old adolescent boys with sexual abuse in Isfahan, in the summer 2018, 45 adolescent were selected based on criteria of entry and then randomly assigne

    Subventricular zone-derived extracellular vesicles promote functional recovery in rat model of spinal cord injury by inhibition of NLRP3 inflammasome complex formation

    Ibrahim Mohammed, Sahar Ijaz, Tahmineh Mokhtari, Morteza Gholaminejhad, Marzieh Mahdavipour, Behnamedin Jameie, Mohammad Akbari, Gholamreza Hassanzadeh
    Journal PaperMetabolic Brain Disease , 2020 March 17, {Pages 10-Jan }

    Abstract

    Spinal cord injury (SCI) is the destruction of spinal cord motor and sensory resulted from an attack on the spinal cord, which can cause significant physiological damage. The inflammasome is a multiprotein oligomer resulting in inflammation; the NLRP3 inflammasome composed of NLRP3, apoptosis-associated speck-like protein (ASC), procaspase-1, and cleavage of procaspase-1 into caspase-1 initiates the inflammatory response. Subventricular Zone (SVZ) is the origin of neural stem/progenitor cells (NS/PCs) in the adult brain. Extracellular vesicles (EVs) are tiny lipid membrane bilayer vesicles secreted by different types of cells playing an important role in cell-cell communications. The aim of this study was to investigate the effect of intrat

    Modulating pro-inflammatory cytokines, tissue damage magnitude, and motor deficit in spinal cord injury with subventricular zone-derived extracellular vesicles

    Sahar Ijaz, Ibrahim Mohammed, Morteza Gholaminejhad, Tahmineh Mokhtari, Mohammad Akbari, Gholamreza Hassanzadeh
    Journal PaperJournal of Molecular Neuroscience , Volume 70 , Issue 3, 2020 March , {Pages 458-466 }

    Abstract

    Background The upregulation of TNF-α, IL-1β, IL-18, and IL-6 exacerbates the spinal cord injury by amplifying the neuroinflammation. Impeding the release and activation of these cytokines can stop the progression of lesion and promote healing. Modulating the inflammatory response with subventricular zone-derived extracellular vesicles (SVZ-EVs) is one highly promising approach. Methods and materials SVZ tissue was cultured and EVs were prepared, isolated, and injected intrathecal, in spinal cord-injured (SCI) rats. BBB locomotor scoring, qRT-PCR, Western Blot, H&E, and Nissl staining techniques were applied to record the outcomes. Results The intracisternally injected SVZ-EVs significantly decreased the gene and protein expression o

    Determining the effectiveness of integrative acceptance and commitment-cognitive behavioral therapy and parent management training on the depression and anxiety of adolescent?…

    Mohammad Akbari, Mohsen Golparvar, Mohsen Lali, Parisa Traneh
    Journal PaperJournal of Jiroft University of Medical Sciences , Volume 7 , Issue 1, 2020 March 10, {Pages 313-322 }

    Abstract

    Materials and Methods: The research method was quasi-experimental, and research design was a three group design. 45 male adolescents were selected by purposive sampling method in Isfahan in 2018 and were randomly assigned to two experimental and one control group (each group 15 persons). Data were collected through depression and anxiety questionnaires at three time points before, after and two months later (follow up). The integrative acceptance and commitment-cognitive behavioral therapy and parent management training received treatment in 10 sessions. The data were analyzed through repeated measure analysis of variance and post-hoc Bonferroni test.Results: Results revealed that integrative acceptance and commitment-cognitive behavioral t

    Comprehensive assessment of association between HLA polymorphisms and acute leukemia in Iranian population

    Arezou Sayad, Mohammad Taghi Akbari, Mohammadreza Ostadali Dehaghi, Amir Ali Hamidieh, Shahram Arsang-Jang, Abbas Hajifathali, Soudeh Ghafouri-Fard, Mohammad Taheri
    Journal PaperGene Reports , 2020 April 10, {Pages 100674 }

    Abstract

    Immune system has a prominent role in both prevention and treatment of leukemia. Based on the role of human leukocyte antigen (HLA) in determination of response to therapeutic options and risk of development of leukemia, several studies have addressed association between HLA alleles and this disorder. Here, we conducted a single-center analysis of HLA-A/-B/-DRB1 distribution in Iranian patients with acute leukemia. The study enrolled 92 patients with acute lymphoblastic leukemia (ALL), 76 patients with acute myeloid leukemia (AML) and 90 healthy controls. HLA-A/-B/-DRB1 alleles were identified using PCR method with sequence specific primers. There was no significant difference in distribution of HLA-A/-B/-DRB1 alleles between three study su

    Intrathecal administration of the extracellular vesicles derived from human Wharton’s jelly stem cells inhibit inflammation and attenuate the activity of inflammasome complexes?…

    Leila Noori, Somayeh Arabzadeh, Yousef Mohamadi, Sina Mojaverrostami, Tahmineh Mokhtari, Mohammad Akbari, Gholamreza Hassanzadeh
    Journal PaperNeuroscience Research , 2020 July 25, {Pages }

    Abstract

    Activation of inflammasome complexes during spinal cord injury (SCI) lead to conversion of pro-inflammatory cytokines, interleukin-1beta (IL-1β) and interleukin-18 (IL-18) to their active form to initiates the neuroinflammation. Mesenchymal stem cells (MSCs) showed anti-inflammatory properties through their extracellular vehicles (EVs). We investigated immunomodulatory potential of human Wharton's jelly mesenchymal stem cells derived extracellular vesicles (hWJ-MSC-EVs) on inflammasome activity one week after SCI in rats. The gene expression and protein level of IL-1β, IL-18, tumor necrosis factor alpha (TNF-α) and caspase1, were assessed by QPCR and western blotting. Immunohistochemistry (IHC) was done to measure the glial fibrillary ac

    The Effect of Integrative Acceptance Commitment-Cognitive Behavioral Therapy and Parent Management Training on the Post Traumatic Stress Disorder Symptoms of Adolescent Boy?…

    Mohammad Akbari, Mohsen Golparvar, Mohsen Lali, Parisa Taraneh
    Journal PaperJournal of Research in Behavioural Sciences , Volume 18 , Issue 1, 2020 March 10, {Pages 101-111 }

    Abstract

    Conclusions: According to the research findings, it is suggested that the integrative ACT-CBT should be used in the treatment of boy adolescents who encountered with sexual abuse to reduce the symptoms of post-traumatic stress disorder.

    Identifying and prioritizing challenges related to promoting the health system performance assessment in Iran

    Somayeh Mahdiyan, Mohamad Akbari, Maede Bozorgi, Mostafa Amini-Rarani
    Journal PaperJournal of Education and Health Promotion , Volume 9 , 2020 January , {Pages }

    Abstract

    MATERIALS AND METHODS:There were two approaches in both qualitative and cross-sectional studies. At first, using semi-structured interviews with 52 performance appraisers, data related to the challenges of promoting the health system performance assessment were collected and thematically analyzed. Then, in cross-sectional terms, the performance appraisers were provided with researcher-made checklists which contained a list of challenges to determine the priority of challenges by scoring. The data were handled and analyzed using MAXQDA Plus version 12 and Microsoft Excel.RESULTS:Our results revealed five themes and ten subthemes on the challenges of promoting the health system performance assessment. Themes (subthemes) included infrastructur

    Extracellular Vesicles Derived from Human Umbilical Cord Perivascular Cells Improve Functional Recovery in Brain Ischemic Rat via the Inhibition of Apoptosis

    Elham Seifali, Gholamreza Hassanzadeh, Marzieh Mahdavipour, Keywan Mortezaee, Ashraf Moini, Leila Satarian, Faezeh Shekari, Abdoreza Nazari, Shabnam Movassaghi, Mohammad Akbari
    Journal PaperIranian biomedical journal , Volume 24 , Issue 6, 2020 November , {Pages 347 }

    Abstract

    Background:Ischemic stroke, as a health problem caused by the reduced blood supply to the brain, can lead to the neuronal death. The number of reliable therapies for stroke is limited. MSCs exhibit therapeutic achievement. A major limitation of MSC application in cell therapy is the short survival span. MSCs affect target tissues through the secretion of many paracrine agents including EVs. This study aimed to investigate the effect of HUCPVCs-derived EVs on apoptosis, functional recovery, and neuroprotection.Methods:Ischemia was induced by MCAO in male Wistar rats. Animals were classified into sham, MCAO, MCAO+ HUCPVC, and MCAO+ EV groups. Treatments began at two hours after ischemia. Expressions of apoptotic-related proteins (BAX/BCl-2 an

    Application of platelet-rich plasma (PRP) improves self-renewal of human spermatogonial stem cells in two-dimensional and three-dimensional culture systems

    Farnaz Khadivi, Morteza Koruji, Mohammad Akbari, Ayob Jabari, Ali Talebi, Sepideh Ashouri Movassagh, Amin Panahi Boroujeni, Narjes Feizollahi, Aghbibi Nikmahzar, Mohammad Pourahmadi, Mehdi Abbasi
    Journal PaperActa Histochemica , Volume 122 , Issue 8, 2020 December 1, {Pages 151627 }

    Abstract

    Spermatogonial stem cells (SSCs) are very sensitive to chemotherapy and radiotherapy, so male infertility is a great challenge for prepubertal cancer survivors. Cryoconservation of testicular cells before cancer treatment can preserve SSCs from treatment side effects. Different two-dimensional (2D) and three-dimensional (3D) culture systems of SSCs have been used in many species as a useful technique to in vitro spermatogenesis. We evaluated the proliferation of SSCs in 2D and 3D culture systems of platelet-rich plasma (PRP). testicular cells of four brain-dead patients cultivated in 2D pre-culture system, characterization of SSCs performed by RT-PCR, flow cytometry, immunocytochemistry and their functionality assessed by xenotransplantatio

    Association of Candidate Single Nucleotide Polymorphisms Related to Candidate Genes in Patients With Schizophrenia

    Seyedeh Sara Karimian, Mohammad Taghi Akbari, Seyed Saeed Sadr, Gholamreza Javadi
    Journal PaperBasic and Clinical Neuroscience , Volume 11 , Issue 5, 2020 September 10, {Pages 595-608 }

    Abstract

    Schizophrenia (SCZ) is a chronic mental disorder. Many genes and environmental factors are involved in SCZ development. NrCAM is a candidate gene for schizophrenia and has been reported in many studies with conflicting results (Ayalew, Le-Niculescu, et al. 2012). NrCAM encodes the neuron cells' adhesion protein molecule and is located on 7q31. 1. The Northern Blotting technique showed a 2 kb transcript of NrCAM in all brain tissues. The 7.0 kb transcript of NrCAM is highly expressed in the brain medulla, adrenal, and adrenal cortex (Lane, et al., 1996, Wang, Williams, Du, Terrett, & Kenwrick, 1998). NrCAM owns 36 exons and is involved in WNT and CAM's signaling pathways (Chen & Zhou 2010, Zhang et al., 2015). NrCAM is one of the twelve gene

    COVID-19 Management in Iran as one of the most affected countries in the world: Advantages and Weaknesses

    Maryam Rassouli, Hadis Ashrafizadeh, Azam Shirinabadi Farahani, Mohammad Esmaeil Akbari
    Journal PaperFrontiers in Public Health , Volume 8 , 2020 January , {Pages }

    Abstract

    COVID-19 management is a hot topic due to its extensive spread across the world and the declaration of pandemic status. How a crisis is managed in each country is influenced by several factors, and various strategies are applied in accordance with these factors in order to manage the crisis. Due to the rapid spread and increasing trend of the crisis and the fact that almost more than half of the countries are engaged in this pandemic, it is impossible to apply trial-and-error based strategies. One of the best strategies is to use the experiences of other countries in dealing with COVID-19. This report explores the advantages and weaknesses of the Islamic Republic of Iran in the management of this crisis in regard with political economic and

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