En
  • دکتری (1385)

    توکسیکولوژی

    شهید بهشتی، تهران، ایران

  • دکتری (1378)

    داروسازی

    جندی شاپور، اهواز، ایران

  • - مکانیسم های سلولی و مولکولی آسیب سلولی با رویکرد نقش میتوکندری
  • - ارزیابی اندامکهای سلولی در مرگ برنامه ریزی شده
  • - سمیت تحریکی و حفاظت عصبی
  • - بررسی نقش میتوکندری در پاتوژنز و درمان بیماری دیابت
  • - ژنوتاکسیسیته و کارسینوژنسیته
  • - بررسی نقش میتوکندری در پاتوژنز و درمان سرطان
  • - بررسی نقش مواد طبیعی و مشتقات آنها در بیماریهای وابسته به میتوکندری

    دکتر محسن رضائی از آغاز سال 1394 به گروه سم شناسی دانشکده علوم پزشکی دانشگاه تربیت مدرس پیوسته است. پیش از آن وی عضو هیئت علمی دانشکده داروسازی جندی شاپور اهواز بوده است. در مدت حضور در دانشگاه جندی شاپور دارای سوابق اجرایی به عنوان معاون مدیر آموزش مداوم دانشگاه، معاون آموزشی دانشکده داروسازی و چند کمیته دانشگاهی بوده است. ایشان عضو انجمن داروسازان، سازمان نظام پزشکی، انجمن سم شناسی کشور و انجمن بین المللی مرگ سلولی می باشد. زمینه های تحقیقاتی وی بررسی مکانیسم های محافظت و آسیب سلولی و ارگانلی با رویکرد بررسی نقش میتوکندری در دیابت، سرطان و بیماریهای نورودژنراتیو می باشد.

    ارتباط

    رزومه

    Intranasal insulin improves mitochondrial function and attenuates motor deficits in a rat 6‐OHDA model of Parkinson's disease

    Farideh Iravanpour, Leila Dargahi, Mohsen Rezaei, Masoud Haghani, Reza Heidari, Neda Valian, Abolhassan Ahmadiani
    Journal PapersCNS Neuroscience & Therapeutics , 2021 January , {Pages }

    Abstract

    Aims Experimental and clinical evidences demonstrate that common dysregulated pathways are involved in Parkinson’s disease (PD) and type 2 diabetes. Recently, insulin treatment through intranasal (IN) approach has gained attention in PD, although the underlying mechanism of its potential therapeutic effects is still unclear. In this study, we investigated the effects of insulin treatment in a rat model of PD with emphasis on mitochondrial function indices in striatum. Methods Rats were treated with a daily low dose (4IU/day) of IN insulin, starting 72?h after 6‐OHDA‐induced lesion and continued for 14?days. Motor performance, dopaminergic cell survival, mitochondrial dehydrogenases activity, mitochondrial swelling, mitochondria pe

    Therapeutic monoclonal antibodies at phase 3 clinical study for management of Covid-19

    Mohsen Rezaei
    Journal Papers , Volume 24 , Issue 1, 2021 March 10, {Pages 51-56 }

    Abstract

    The new coronavirus was firstly identified in the late December 2019 that causes severe respiratory and other organ complications in Covid-19 patients. Although many attempts have beenemployed to introduce and provideeffective medications against this infection, there is still no definitive treatment for the infection. However some agents have shown promising effects in patients and some others are inpreliminaryor clinical studies. Monoclonal antibodies are of great interest in the treatment of Covid-19, but despite the fact that more than 120 clinical trials have been performed or are being completed; only tocilizumab has shown promising results and is sometimes used in therapeutic protocols. In this review, therapeutic monoclonal antibodi

    Arsenic and weight loss: At a crossroad between lipogenesis and lipolysis

    S Handali, M Rezaei
    Journal Papers , , {Pages }

    Abstract

    Lovastatin attenuates glyoxal-induced toxicity on rat liver mitochondria

    A Hosseinzadeh, S Mehrzadi, M Rezaei, M Badavi, A Nesari, M Goudarzi
    Journal Papers , , {Pages }

    Abstract

    N‐acetylcysteine is more effective than ellagic acid in preventing acrolein induced dysfunction in mitochondria isolated from rat liver

    B Shafie, J Pourahmad, M Rezaei
    Journal Papers , , {Pages }

    Abstract

    Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation

    F Khodaei, SM Hosseini, M Omidi, SF Hosseini, M Rezaei
    Journal Papers , , {Pages }

    Abstract

    Evaluation of Molecular and Cellular Alterations Induced by Neuropathic Pain in Rat Brain Glial cells

    M Rezaei, L Karimian, B Shafaghi, M Noubarani, M Salecheh, ...
    Journal Papers , , {Pages }

    Abstract

    Mitochondria and cancer therapy

    S Handali, M Rezaei, J Pourahmad
    Journal Papers , , {Pages }

    Abstract

    Mitotherapy, an attractive avenue for the future medicine

    J Pourahmad, S Handali, M Rezaei
    Journal Papers , , {Pages }

    Abstract

    Mitochondria as balancers of reduction/oxidation for intracellular environment

    M Rezaei, S Handali, J Pourahmad
    Journal Papers , , {Pages }

    Abstract

    Interlink between improved formulations, inhibitory concentrations and cell death mechanism investigations of cytotoxic drugs: What really matters?

    Somayeh Handali, Mohsen Rezaei
    Journal Papers , 2020 February 4, {Pages }

    Abstract

    In this article, IC50 concentrations derived from MTT assay for further evaluating of cell death induced by new formulations were discussed. This review attempts to introduce an enhanced approach for evaluation of cell death mechanisms based on routine cytotoxicity assays for anti-cancer medications. It is highly desirable for anti-cancer drugs to induce apoptotic cell death in order to have better efficacy and less complications. According to our previous results and other comparable studies, cell death mechanisms and phenotypes followed by cytotoxic drugs are rigorously concentration dependent; therefore, calculated IC50s obtained through cytotoxicity assays should be exactly employed for evaluating of cell death mechanisms. More appropri

    Subcellular Organelle Toxicity Caused by Arsenic Nanoparticles in Isolated Rat Hepatocytes

    Rashid Jahangirnejad, Mehdi Goudarzi, Heibatullah Kalantari, Hossein Najafzadeh, Mohsen Rezaei
    Journal PapersInt J Occup Environ Med (The IJOEM) , Volume 11 , Issue 01-Jan, 2020 January 5, {Pages 1614-41-52 }

    Abstract

    Methods: Freshly isolated rat hepatocytes were exposed to 0, 20, 40, and 100 μM of arsenic nanoparticles and its bulk counterpart. Their viability, reactive oxygen species level, glutathione depletion, mitochondrial and lysosomal damage, and apoptosis were evaluated.Results: By all concentrations, lysosomal damage and apoptosis were clearly evident in hepatocytes exposed to arsenic nanoparticles. Evaluation of mitochondria and lysosomes revealed that lysosomes were highly damaged.Conclusion: Exposure to arsenic nanoparticles causes apoptosis and organelle impairment. The nanoparticles have potentially higher toxicity than the bulk arsenic. Lysosomes are highly affected. It seems that, instead of mitochondria, lysosomes are the first target

    Mesobuthus eupeus venom induced injury in the colorectal carcinoma cell line (HT29) through altering the mitochondria membrane stability

    Massood Valizade, Atefeh Raesi Vanani, Mohsen Rezaei, Layasadat Khorsandi, Leila Zeidooni, Masoud Mahdavinia
    Journal PapersIranian Journal of Basic Medical Sciences , Volume 23 , Issue 6, 2020 June 1, {Pages 760-767 }

    Abstract

    Objective(s): The purpose of this study was to investigate cytotoxicity and membrane toxicity effects induced by Mesobuthus eupeus venom (MEV) on the HT-29 cell line. Materials and Methods: To determine the in vitro cytotoxicity via MTT assays, HT-29 (as cancer cell line) and Hek-293T (as normal cell) were treated through different concentrations of MEV, and cytotoxicity effects were then measured through assessment of mitochondrial membrane potential (ΔΨm), reactive oxygen species (ROS) generation, and apoptosis induction. The colony formation assay was performed to measure the antiproliferative effect of MEV on HT-29 cells. Nuclei alterations were also observed during apoptosis following DAPI staining. Besides, atomic force microscopy (

    Toxicity of fluoride on isolated rat liver mitochondria

    Sohrab Rahmani, Mohsen Rezaei
    Journal PapersJournal of Fluorine Chemistry , Volume 239 , 2020 November 1, {Pages 109636 }

    Abstract

    Fluoride is abundant in the environment and exists mostly in combination with other elements as fluoride compounds. Several studies showed that exposing to irregular level of fluoride could impair the normal function of mitochondria that have major contribution for producing of reactive oxygen species (ROS). However, information about the exact mechanism behind the fluoride-induced mitochondrial damage has not been fully understood. In the present study, isolated rat liver mitochondria were exposed to different concentrations of sodium fluoride (NaF) for 30 min and their functionality was assessed at the presence of different concentrations of N-acetylcysteine (NAC) and IC50 concentration of NaF. Mitochondrial dehydrogenase activity, glutat

    Mitochondria-Targeted Polyamidoamine Dendrimer–Curcumin Construct for Hepatocellular Cancer Treatment

    Shahla Kianamiri, Ali Dinari, Majid Sadeghizadeh, Mohsen Rezaei, Bahram Daraei, Noor El-Huda Bahsoun, Alireza Nomani
    Journal PapersMolecular Pharmaceutics , 2020 November 18, {Pages }

    Abstract

    Mitochondrial malfunction plays a crucial role in cancer development and progression. Cancer cells show a substantially higher mitochondrial activity and greater mitochondrial transmembrane potential than normal cells. This concept can be exploited for targeting cytotoxic drugs to the mitochondria of cancer cells using mitochondrial-targeting compounds. In this study, a polyamidoamine dendrimer-based mitochondrial delivery system was prepared for curcumin using triphenylphosphonium ligands to improve the anticancer efficacy of the drug in vitro and in vivo. For the in vitro evaluations, various methods, such as viability assay, confocal microscopy, flow cytometry, reactive oxygen species (ROS), and real-time polymerase chain reaction analys

    Measuring and comparing the ethanol level in traditional and industrial vinegars in Halal food industry

    Marzieh Jafari, Mohsen Rezaei
    Journal PapersIslam And Health Journal , Volume 5 , Issue 2, 2020 August 10, {Pages 12-Jul }

    Abstract

    Methods: To measure the amount of alcohol in vinegars, the samples were diluted and filtrated, then injected into a gas chromatography. In order to investigate the effect of time on the amount of alcohol production and conversion, the measurements were carried out at different time intervals.Findings: Some amounts of alcohol were found both in industrial and traditional vinegar. The alcohol percentage was higher in traditional than industrial vinegars.Conclusion: The high alcohol content of traditional vinegars compared to the industrial ones can be related to the difference in the methods of preparation of these two types of vinegars. Moreover, since over time, there is a significant difference in the amount of alcohol in vinegar, in the p

    Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation

    Forouzan Khodaei, Sayed M Hosseini, Mahmoud Omidi, Seyede F Hosseini, Mohsen Rezaei
    Journal PapersJournal of Biochemical and Molecular Toxicology , 2020 November 4, {Pages e22662 }

    Abstract

    Cancer and diabetes, the two mitochondria‐related diseases, have recently been linked to silent mating‐type information regulation 2 homolog 3 (SIRT3) activity irregularities. In this study, the effect of metformin, an antidiabetic with anticancer properties, has been evaluated on mitochondrial functionality markers, cell death pathways, and SIRT3 enzyme activity in the colon cancer cell line,?HT‐29, and human embryonic kidney cells (HEK 293). HT‐29 cells were treated with metformin (5, 10, 20, 40, and 80 ?M) for 24, 48, and 72 h for measuring the IC50 concentration. Reactive oxygen species (ROS) production, apoptosis, mitochondrial membrane potential, SIRT3 activity, and expression were evaluated against the colon cancer cell

    Synergy Effects of Metformin and Berberine on Glyoxal-induced Carbonyl Stress in Isolated Rat Liver Mitochondria

    Mohsen Rezaei, Heibatullah Kalantari, Saeed Mehrzadi, Mehdi Goudarzi
    Journal PapersCurrent Drug Therapy , Volume 15 , Issue 5, 2020 October 1, {Pages 493-502 }

    Abstract

    Objective: Carbonyl stress, resulting from toxic effects of alpha-dicarbonyls such as glyoxal (GO), plays an important role in mitochondrial dysfunction and subsequent development of diabetic complications. This study evaluated the ability of metformin (MET), berberine (BBR), and their combination to prevent GO-induced carbonyl stress in isolated rat liver mitochondria. Methods: Mitochondria (0.5 mg protein/mL) were isolated from the Wistar rat liver and incubated with various concentrations of GO (1, 2.5, 5, 7.5, and 10 mM) for 30 minutes and IC50 for GO was calculated. The suspensions of mitochondria were incubated with various concentrations of MET (2.5, 5, 10, and 20 mM) or BBR (2.5, 5, 10, and 20 μM) for 30 min and then GO in a dose o

    Measuring and comparing the ethanol level in traditional and industrial vinegars in Halal food industry

    Marzieh Jafari, Mohsen Rezaei
    Journal PapersIslam And Health Journal , Volume 5 , Issue 2, 2020 August 10, {Pages 12-Jul }

    Abstract

    Methods: To measure the amount of alcohol in vinegars, the samples were diluted and filtrated, then injected into a gas chromatography. In order to investigate the effect of time on the amount of alcohol production and conversion, the measurements were carried out at different time intervals.Findings: Some amounts of alcohol were found both in industrial and traditional vinegar. The alcohol percentage was higher in traditional than industrial vinegars.Conclusion: The high alcohol content of traditional vinegars compared to the industrial ones can be related to the difference in the methods of preparation of these two types of vinegars. Moreover, since over time, there is a significant difference in the amount of alcohol in vinegar, in the p

    Protective Effect of N-acetyl-cysteine Against Rat Liver Mitochondrial Toxicity Induced by CuSO4

    Sohrab Rahmani, Mohsen Rezaei
    Journal Papers , Volume 14 , Issue 6, 2020 January 1, {Pages 17-Sep }

    Abstract

    Background and Objectives: Copper sulfate (CuSO4) is a toxic substance with a broad range of applications; however, the ingestion of high levels of it cause a wide range of complications in the liver tissue. According to previous studies, mitochondria are potential targets for CuSO4 toxicity. The present study aimed to examine the role of N-acetyl-cysteine as an antioxidant agent in the protection of mitochondria against toxicity induced by CuSO4.Methods: This study was performed on isolated liver mitochondria extracted from male Wistar rats (180-200 g) by multiple centrifuges and finally divided into 5 different groups. Group 1 was the control group, while group 2 received a single dose of 106 ?M of CuSo4. The other groups were pretreated

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    دروس نیمسال جاری

    • دكتري
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      دانشکده علوم پزشکی، گروه انگل شناسي
    • دكتري
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    • كارشناسي ارشد
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    • كارشناسي ارشد
      سم شناسي عملي ( واحد)
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      فارماكولوژي ( واحد)

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      دانشکده علوم پزشکی، گروه سم شناسي
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