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  • دکتری (1382)

    فیزیولوژی پزشکی

    دانشگاه علوم پزشکی شهید بهشتی ،

  • کارشناسی‌ارشد (1375)

    زیست شناسی - فیزیولوژی

    دانشگاه شهید بهشتی، تهران، ایران

  • کارشناسی (1373)

    زیست شناسی

    دانشگاه فردوسی مشهد، مشهد، ایران

  • ترمیم و حفاظت میلین و آکسون در بیماری MS
  • کاربرد فناوری سلولهای بنیادی عصبی در بیماریهای نورودژنراتیو
  • آزمایشگاه ترمیم عصبی

متولد شهر انابد در شهرستان برداسکن در خراسان رضوی می باشم. دوره کارشتاسی ریست شناسی را در دانشگاه فردوسی مشهد، کارشناسی ارشد را در دانشگاه شهید بهشتی و دوره دکتری را در دانشگاه علوم پزشکی شهید بهشتی گذراندم. پس از طی دوره فرادکتری در دانشگاه کیورین در توکیو، از سال ۱۳۸۳ در گروه فیزیولوژی پزشکی دانشگاه تربیت مدرس شروع به کار نمودم.

ارتباط

رزومه

An optimized animal model of lysolecithin induced demyelination in optic nerve; more feasible, more reproducible, promising for studying the progressive forms of multiple sclerosis

Samaneh Dehghan, Ehsan Aref, Mohammad Reza Raoufy, Mohammad Javan
Journal PapersJournal of Neuroscience Methods , Volume 352 , 2021 March 15, {Pages 109088 }

Abstract

BackgroundMultiple Sclerosis (MS) is a demyelinating disease leading to long-term neurological deficit due to unsuccessful remyelination and axonal loss. Currently, there are no satisfactory treatments for progressive MS somewhat due to the lack of an adequate animal model for studying the mechanisms of disease progression and screening new drugs.New methodLysolecithin (LPC) or agarose-gel loaded LPC (AL-LPC) were applied to mouse optic nerve behind the globe via a minor surgery. Agarose loading was used to achieve longer time of LPC exposure and subsequently long-lasting demyelination.ResultsThe lesion sites characterized by luxol fast blue (LFB), FluoroMyelin, Bielschowsky’s staining, and immunostaining showed extensive demyelination an

Targeting the Brain Lesions Using Peptides: A Review Focused on the Possibility of Targeted Drug Delivery to Multiple Sclerosis Lesions

Atefeh Rayatpour, Mohammad Javan
Journal Papers , 2021 January 24, {Pages 105441 }

Abstract

As described by Jean Martin Charcot in 1868, multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS) which leads to permanent disability in patients. Following CNS insults, astrocytes and microglial cells undergo changes, which lead to scar formation in the site of injury. Owning to the pathophysiology of MS lesions, changes in both cellular and extracellular matrix (ECM) components occur over the progression of disease. In spite of advances in therapeutic approaches, drug delivery to MS lesions appears of great interest with big challenges and limitations. Targeting with peptides is a novel promising approach in the field of drug delivery. Recently peptides have been used

Metformin Protects Myelin from Degeneration in A Mouse Model of Iysophosphatidylcholine-Induced Demyelination in The Optic Chiasm

Saman Esmaeilnejad, Saeed Semnanian, Mohammad Javan
Journal PapersCell Journal , Volume 23 , Issue 1, 2021 January 1, {Pages 119-128 }

Abstract

Objective: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. The autoimmune pathology and long-term inflammation lead to substantial demyelination. These events lead to a substantial loss of oligodendrocytes (OLs), which in a longer period, results in axonal loss and long-term disabilities. Neural cells protection approaches decelerate or inhibit the disease progress to avoid further disability. Previous studies showed that metformin has beneficial effects against neurodegenerative conditions. In this study, we examined possible protective effects of metformin on toxin-induced myelin destruction in adult mice brains.Materials and Methods: In this experimental study, lysophosphatidylcholine (LPC) was used to i

Deep brain stimulation effects on learning, memory and glutamate and GABAA receptor subunit gene expression in kindled rats

Mona Faraz, Nastaran Kosarmadar, Mahmoud Rezaei, Meysam Zare, Mohammad Javan, Victoria Barkley, Amir Shojaei, Javad Mirnajafi‑Zadeh
Journal PapersActa Neurobiol Exp , Volume 81 , 2021 January 1, {Pages 43-57 }

Abstract

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. TLE is characterized by recur‑rent, spontaneous seizures that originate from the temporal lobe (Falconer et al., 1964). The main thera‑peutic intervention for epileptic patients is antiepilep‑tic drugs, but 20–30% of epileptic patients are drug re‑sistant (Schmidt and Schachter, 2014). Therefore, more research has been dedicated to finding new therapies for epilepsy.Over the last decade, deep brain stimulation has been suggested as a treatment for patients with drug‑resistant epilepsy and patients who are not sur‑gical resection candidates (Jobst et al., 2010). Low fre‑quency stimulation (LFS), in the range of 0.5 to 5 Hz, has been shown to suppress seiz

The cross talk between underlying mechanisms of multiple sclerosis and epilepsy may provide new insights for more efficient therapies

A Rayatpour, S Farhangi, E Verdaguer, J Olloquequi, J Ureña, C Auladell, ...
Journal Papers , , {Pages }

Abstract

Unconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits

G Ghamkharinejad, SH Marashi, F Foolad, M Javan, Y Fathollahi
Journal Papers , , {Pages }

Abstract

Promising application of metformin in Alzheimer's disease

S Rabiei Poor, M Ettcheto Arriola, A Cano Fernández, E Sánchez-López, ...
Journal Papers , , {Pages }

Abstract

Metformin a potential pharmacological strategy in late onset Alzheimer’s disease treatment

SR Poor, M Ettcheto, A Cano, E Sanchez-Lopez, PR Manzine, ...
Journal Papers , , {Pages }

Abstract

Molecular Properties of Ca2+ Transport Through TRPV2 Channel: A Molecular Dynamic Simulations Study

M Alipour, B Hajipour-Verdom, P Abdolmaleki, M Javan
Journal Papers , , {Pages }

Abstract

Fingolimod Regulates BDNF-AS and HOTAIR Expression in Multiple Sclerosis Patients

MA Sahraian, M Javan, M Behmanesh
Journal Papers , , {Pages }

Abstract

Corrigendum to" Enhanced Remyelination Following Lysolecithin-induced Demyelination in Mice Under Treatment with Fingolimod (FTY720)"[Neuroscience 311 (2015) 34-44]

A Yazdi, H Baharvand, M Javan
Journal Papers , , {Pages }

Abstract

Hotair and Malat1 Long Noncoding RNAs regulate Bdnf Expression and Oligodendrocyte Precursor Cells Differentiation

L Zare, MA Sahraian, M Javan, M Behmanesh
Journal Papers , , {Pages }

Abstract

Fingolimod Regulates BDNF-AS and HOTAIR Expression in Multiple Sclerosis Patients

F khani Habibabadi, MA Sahraian, M Javan, M Behmanesh
Journal Papers , , {Pages }

Abstract

Prenatal stress promotes icv-STZ-induced sporadic Alzheimer's pathology through central insulin signaling change

Farzaneh Rostami, Mohammad Javan, Ali Moghimi, Aliakbar Haddad-Mashadrizeh, Masoud Fereidoni
Journal PapersLife Sciences , Volume 241 , 2020 January 15, {Pages 117154 }

Abstract

AimInsulin resistance and neuroinflammation play roles in Alzheimer's (AD) etiology. Insulin receptors (IR) are developmentally expressed in neurons as well as astrocytes. Moreover, prolonged stress can induce brain insulin resistance and astrogliosis. Also, prenatal stress could advance AD-related abnormalities in a transgenic model of AD. Besides, postnatal maternal care (PMC) has antagonistic effects on prenatal stress (PS)-induced neuronal and immunological malfunctions. Using an icv-STZ subclinical model of sAD, we assessed PS and/or abnormal PMC impacts on advancing sAD-like pathology in adult male rats. We also sought astrocyte- and/or neuron-oriented change in central insulin programming.Main methodsPregnant rats were exposed to PS.

Enhancing myelin repair in experimental model of multiple sclerosis using immobilized chondroitinase ABC I on porous silicon nanoparticles

Safoura Rezaei, Bahareh Dabirmanesh, Leila Zare, Abolfazl Golestani, Mohammad Javan, Khosro Khajeh
Journal PapersInternational Journal of Biological Macromolecules , Volume 146 , 2020 March 1, {Pages 162-170 }

Abstract

Removal of chondroitin sulfate proteoglycans (CSPGs) with chondroitinase ABC I (ChABC) facilitates axonal plasticity, axonal regeneration and remyelination, following injury to the central nervous system (CNS). However, the ChABC rapidly undergoes thermal inactivity and needs to be injected repeatedly. Here this limitation was overcame by immobilizing the ChABC on porous silicon (PSi) nanoparticles (ChABC@PSi). The efficacy of immobilized ChABC on CSPGs level and the demyelination insult was assessed in mice corpora callosa demyelinated by 6?weeks cuprizone (CPZ) feeding. ChABC@PSi was able to reduce the amount of CSPGs two weeks after animals treatment. CSPGs digestion by ChABC@PSi reduced the extent of demyelinated area as well as the ast

Long-term potentiation enhancing effect of epileptic insult in the CA1 area is dependent on prior-application of primed-burst stimulation

Masoumeh Gholami, Narges Hosseinmardi, Javad Mirnajafi-Zadeh, Mohamad Javan, Saeed Semnanian, Nasser Naghdi, Yaghoub Fathollahi
Journal PapersExperimental Brain Research , 2020 March 12, {Pages 07-Jan }

Abstract

Herein field recordings were utilized to test the effects of a transient period of pentylenetetrazol (PTZ) treatment on theta-burst long-term potentiation (LTP) at the Schaffer collateral-CA1 synapses as well as RT-PCR was used to investigate the effects of the combination of the pharmacological treatment and the theta-burst LTP induction on the expression of NMDA subunit mRNA in hippocampal slices. The slope of field excitatory postsynaptic potential (fEPSP) was unaffected while the population spike amplitude and area were increased by a transient period of PTZ treatment (3?mM, 10?min). After a theta burst, a brief PTZ exposure can lead to an enhancement of LTP as documented by fEPSP recording. The effect can be blocked by a s

Sub-threshold electrical stimulation improves winglesstype3 and eukaryotic initiation factor-2α expression in the presence of exogenous astrocyte in the rat model of spinal?…

Meysam Ghorbani, Parviz Shahabi, Pouran Karimi, Mohammad Javan, Soheila Bani, Saba Hoseini, Hamid Soltani-Zangbar, Behnaz Sadeghzadeh-Oskouei
Journal PapersPhysiology & Pharmacology , Volume 24 , Issue 1, 2020 March 1, {Pages }

Abstract

Introduction: Spinal cord injury (SCI) is a condition which can lead to permanent loss of neurons, glial and precursor cells. According to the positive influences of electrical stimulation in the neurogenesis, we hypothesized that sub-threshold electrical stimulation in the presence of exogenous astrocyte may trigger the differential regulation of wingless-type3 (Wnt-3) and eukaryotic initiation factor-2α (eIF2α) mediators in spinal cord injured rats. Results: The results show that expression of Wnt-3 and eIF2α proteins significantly enhanced after 14 days in the electrical stimulation+ SCI+ astrocyte group in comparison with SCI and SCI+ astrocyte groups. Also, the expression of GFAP cells was significantly increased after 14 days by el

Inhibition of orexin receptor 1 contributes to the development of morphine dependence via attenuation of cAMP response element-binding protein and phospholipase Cβ3

Masoumeh Kourosh-Arami, Mohammad Javan, Saeed Semnanian
Journal PapersJournal of Chemical Neuroanatomy , 2020 May 11, {Pages 101801 }

Abstract

Noradrenergic neurons of the locus coeruleus (LC) receive projection from hypothalamus orexinergic neurons and express orexin 1 receptor (Orx1). Orx in the locus coeruleus nucleus is involved in the development of morphine dependence. The downstream signaling of Orx contribution to the development of morphine dependence in LC neurons of morphine-dependent rats was studied. Therefore, we evaluated cyclic adenosine monophosphate (cAMP), cAMP response element-binding protein (CREB) and phospholipase Cβ3 (PLCβ3) levels by the application of immunohistochemistry. Results showed that cAMP, CREB and PLCβ3 levels were suppressed by the application of SB-334867 (as a selective Orx1 antagonist) in morphine-dependent rats. Our results unraveled tha

Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination

Hannaneh Roshanbakhsh, Mahmoud Elahdadi Salmani, Samaneh Dehghan, Atena Nazari, Mohammad Javan, Fereshteh Pourabdolhossein
Journal PapersLife Sciences , 2020 April 24, {Pages 117671 }

Abstract

AimsWe still do not have effective treatment for hippocampal demyelination and memory deficit, the two common comorbidities in multiple sclerosis (MS). This study aimed to assess the therapeutic effect of Piperine (the main alkaloid of black pepper) in an experimental model of demyelination.Main methodsDemyelination was induced in male Wistar rats by bilateral injection of lysolecithin (LPC) into the CA1 region of the hippocampus. Piperine (5, 10, 20 mg/kg) was daily injected intraperitoneally three days post LPC injection for ten days. The spatial memory was examined by the Morris water maze task. Demyelination and astrocyte activation were assessed by an immunohistological study. The gene expression analysis of TNF-α, IL1-β, NF-κB, I

Changes in mitochondrial function in patients with neuromyelitis optica; correlations with motor and cognitive disabilities

Forough Foolad, Fariba Khodagholi, Seyed Massood Nabavi, Mohammad Javan
Journal PapersPloS one , Volume 15 , Issue 3, 2020 March 26, {Pages e0230691 }

Abstract

Background Neuromyelitis Optica (NMO) is an inflammatory demyelinating disease that mainly affects optic nerves and spinal cord. Besides, loss of motor and cognitive function has been reported as important symptoms of disease. Objective Here we investigated the mitochondrial dysfunction and metabolic alterations in NMO patients and evaluate their correlation with disease progress, disability and cognitive impairment. Methods The individuals (12 controls and 12 NMO) were assessed for disease severity by expanded disease status scale (EDSS), cognitive function via symbol digit modalities test (SDMT) and fine motor disability by 9-hole peg test (9-HPT). We have measured Sirtuin 1 (SIRT1), SIRT3, mitochondrial complex I, complex IV, aconita

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دروس نیمسال جاری

  • دكتري
    مباحث جديد و پيشرفته در فيزيولوژي سلول ( واحد)
    دانشکده علوم پزشکی، گروه فيزيولوژي
  • دكتري
    مباحث جديد و پيشرفته در اعصاب و حواس ويژه ( واحد)
  • دكتري
    بيولوژي سلولي - مولكولي ( واحد)
  • دكتري
    بيولوژي سلولي - مولكولي ( واحد)
  • دكتري
    علوم اعصاب شناختي 2 ( واحد)

دروس نیمسال قبل

  • دكتري
    علوم اعصاب شناختي زبان ( واحد)
    دانشکده علوم پزشکی، گروه زبان شناسي
  • كارشناسي ارشد
    فيزيولوژي سلول ( واحد)
  • كارشناسي ارشد
    بيولوژي مولكولي ( واحد)
  • دكتري
    نوروبيولو ژي سلولي و ملكولي ( واحد)
  • 1400
    دوست, ريحانه
    بررسي اثر دفريپرون بر توزيع آهن بين سلولهاي ميكروگليا و اليگودندروسيت و فنوتيپ ميكروگلياها در مدل حيواني تخريبميلين عصب بينايي
  • 1394
    شريفي كليشادي, محسن
    تبديل سلولهاي آستروسيت به سلول هاي دودمان اليگودندروسيتي با استفاده از ريز مولكول هاي موثر بر مسيرهاي سيگنالينگ سلول هاي گليال
  • 1397
    باجووند, شيرين
  • 1400
    توكلي يركي, مليكا
  • مدیر گروه فیزیولوژی
  • عضو شورای پژوهشی دانشکده علوم پزشکی
  • عضو کمیته داوران و طراحان سوال المپیاد علوم پزشکی
  • سردبیر مجله Physiology and Pharmacology
  • دبیر اجرایی مجله Physiology and Pharmacology
  • معاون پژوهشی و فناوری دانشکده علوم پزشکی
  • دبیر انجمن فیزیولوژی و فارماکولوژی ایران
  • رئیس انجمن فیزیولوژی و فارماکولوژی ایران
  • دبیر کمیته اخلاق در تحقیقات زیست پزشکی دانشگاه
  • استاد سرآمد آموزشی

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