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Importance of SARA-COV-2 serological tests in diagnosis, vaccination and treatment

Hoorieh Soleimanjahi
Journal PapersPathobiology Research , Volume 24 , Issue 1, 2021 March 10, {Pages 89-97 }

Abstract

SARS-COV-2, the latest member of Coronaviridea family as the cause of the recent global epidemic, has inflicted sever damages in different fields on most governments. Appropriate strategies such as identifying infected individuals and isolating them, trying to produce an effective vaccine, finding efficient treatment and making correct decisions in the social, economic and health fields are the current priorities of the world. Simultaneous serological tests with molecular tests have led to a reduction in false-negative cases of these tests, which leads to the timely isolation of more patients and less spread of the disease. Evaluation of humoral immune responses by serological tests contribute to effective vaccine production. Serological te

Frequency of Cytomegalovirus Viral Load in Iranian Human Immunodeficiency Virus-1-Infected Patients with CD4+ Counts< 100 Cells/mm3

Mohammad Reza Jabbari, Hoorieh Soleimanjahi, Somayeh Shatizadeh Malekshahi, Mohammad Gholami, Leila Sadeghi, Minoo Mohraz
Journal PapersIntervirology , 2021 March 31, {Pages 05-Jan }

Abstract

Objectives: The aim of present work was to assess cytomegalovirus (CMV) viremia in Iranian human immunodeficiency virus (HIV)-1-infected patients with a CD4+ count< 100 cells/mm 3 and to explore whether CMV DNA loads correlate with CD4+ cell counts or associated retinitis. Methods: This study was conducted at the AIDS research center in Iran on HIV-1-infected patients with CD4+ count< 100 cells/mm 3, antiretroviral therapy-naive, aged≥ 18 years with no previous history of CMV end-organ disease (CMV-EOD). Results: Thirty-nine of 82 patients (47.56%) had detectable CMV viral load ranging from 66 to 485,500 IU/mL. CMV viral load in patients with retinitis ranges from 352 to 2,720 IU/mL, and it was undetectable in 2 patients. No significant a

Evaluation of Mutation Spread in The SARS-CoV2 Genome

Kamal Fakhredini, Hooreih Soleimanjahi, Razieh Sadat Banijamali, Taravat Bamdad
Journal PapersPathobiology Research , Volume 24 , Issue 1, 2021 March 10, {Pages 41-49 }

Abstract

The Coronaviridae family includes viruses that are considered the causative agents of respiratory infections, and among human RNA viruses have the largest genome. Coronaviruses undergo elusive genetic changes through mutation during replication. A gene mutation is a permanent alteration in the nucleic acid sequence; if it occurs in large numbers, it causes changes in the biological features of a species. Fundamentally, viruses adapt to the human body during replication. Several studies have shown that most mutations do not have much effect on pathogenicity. Sequence diversity in new coronaviruses is very low. However, antigen drift has been observed among some coronaviruses. Most coronavirus mutations occur intermittently in Iran and other

MSCs loaded with oncolytic reovirus: migration and in vivo virus delivery potential for evaluating anti-cancer effect in tumor-bearing C57BL/6 mice

Seyed-Mahmood Seyed-Khorrami, Hoorieh Soleimanjahi, Sara Soudi, Ala Habibian
Journal PapersCancer Cell International , Volume 21 , Issue 1, 2021 December , {Pages 19-Jan }

Abstract

Several oncolytic viruses applications have been approved in the clinic or in different phases of clinical trials. However, these methods have some rudimentary problems. Therefore, to enhance the delivery and quality of treatment, considering the advantage of cell carrier-based methods such as Mesenchymal Stem Cells (MSC) have been proposed. This study was designed to evaluate the performance and quality of cancer treatment based on MSCs loaded by oncolytic reovirus in the cancerous C57BL/6 mouse model. Also, we evaluated MSCs migration potency in vitro and in vivo following the oncolytic reovirus infection. C57BL/6 mice were inoculated with TC-1 cell lines and tumors were established in the right flank. Mice were systemically treated with

Low-intensity ultrasound as a novel strategy to improve the cytotoxic effect of oncolytic reovirus on colorectal cancer model cells

N Sharifi, H Soleimanjahi, M Mokhtari-Dizaji, RS Banijamali, ...
Journal Papers , , {Pages }

Abstract

Mesenchymal stem cells loaded with oncolytic reovirus enhances antitumor activity in mice models of colorectal cancer

A Babaei, H Soleimanjahi, M Soleimani, E Arefian
Journal Papers , , {Pages }

Abstract

Mesenchymal stem cells support delivery and boost the efficacy of oncolytic reoviruses in TC‐1 tumor cells

RS Banijamali, H Soleimanjahi, S Soudi, H Karimi
Journal Papers , , {Pages }

Abstract

Comparison of the Effect of Adipose Mesenchymal Stem Cells-derived Secretome with and without Reovirus in CT26 Cells

A Rezazadeh, H Soleimanjahi, S Soudi, A Habibian
Journal Papers , , {Pages }

Abstract

Reovirus and Rotaviruses: Basic General, Molecular, Clinical, and Application Features

H Soleimanjahi, FH Heydarabadi
Journal Papers , , {Pages }

Abstract

Papillomaviruses: Basic General, Molecular, Clinical and Immune Evasion Mechanisms

H Soleimanjahi, A Habibian
Journal Papers , , {Pages }

Abstract

SARS-CoV-2 seroprevalence in asymptomatic or mild symptomatic people and symptomatic patients with negative PCR results: The hidden perspective in epidemiological reports

N Hajiahmadi, A Yari, M Tat, H Soleimanjahi, SA Jamehdar, M Jafari, ...
Journal Papers , , {Pages }

Abstract

Importance of SARA-COV-2 serological tests in diagnosis, vaccine productin and treatment

N Hajiahmadi, H Soleimanjahi, T Bamdad
Journal Papers , , {Pages }

Abstract

Kinetics of Oncolytic Reovirus T3D Replication and Growth Pattern in Mesenchymal Stem Cells

Razieh Sadat Banijamali, Hoorieh Soleimanjahi, Sara Soudi, Hesam Karimi, Asghar Abdoli, Seyed Mahmood Seyed Khorrami, Keivan Zandi
Journal PapersCell journal , Volume 22 , Issue 3, 2020 October , {Pages 283 }

Abstract

Objective: Currently, application of oncolytic-virus in cancer treatment of clinical trials are growing. Oncolytic-reovirus is an attractive anti-cancer therapeutic agent for clinical testing. Many studies used mesenchymal stem cells (MSCs) as a carrier cell to enhance the delivery and quality of treatment with oncolytic-virotherapy. But, biosynthetic capacity and behavior of cells in response to viral infections are different. The infecting process of reoviruses takes from two-hours to one-week, depends on host cell and the duration of different stages of virus replication cycle. The latter includes the binding of virus particle, entry, uncoating, assembly and release of progeny-viruses. We evaluated the timing and infection cycle of reovi

The Convenient and Economical Method to Collect Adipose Mesenchymal Stem Cells

Hoorieh Soleimanjahi
Journal PapersArchives of Medical Laboratory Sciences , Volume 5 , Issue 1, 2020 May 3, {Pages }

Abstract

Background: Enzymatic digestion is an essential stage for culturing Mesenchymal Stem Cells (MSCs) and their therapeutic application. Several factors such as being cost-benefit, efficiency, safety, yield and amount of produced cells are determinant for choosing the appropriate enzyme. Collagenase is a conventional enzyme commonly used for enzymatic digestion. However, other enzymes like trypsin and even combination of these enzymes can be used as an alternative strategy in different situations.Materials and Methods: Abdominal subcutaneous adipose tissue was obtained from male BALB/c mice and digested under three different enzymatic processes: collagenase and collagenase/trypsin and trypsin. Cell culture process was performed under standard c

combination therapy using human papillomavirus L1/E6/E7 genes and archaeosome: a nanovaccine confer immuneadjuvanting effects to fight cervical cancer

Hesam Karimi, Hoorieh Soleimanjahi, Asghar Abdoli, Razieh Sadat Banijamali
Journal PapersScientific reports , Volume 10 , Issue 1, 2020 April 1, {Pages 15-Jan }

Abstract

Cancer is a leading cause of death worldwide. Cervical cancer caused by human papillomavirus (HPV) is a major health problem in women. DNA vaccines are a perfect approach to immunization, but their potency in clinical trials has been insufficient for generating effective immunity, which may be related to the degradation of the DNA via nucleases, poor delivery to antigen-presenting cells (APCs), and insufficient uptake of DNA plasmids by cells upon injection. Archaeosome is a nano-delivery systems based on liposomes with their immunological role have been developed for gene delivery. In this study, human papillomavirus type 16 genes, containing truncated L1, E6, and E7, were simultaneously used in combination therapy with archaeosome and ass

The synergistic anticancer effects of ReoT3D, CPT-11, and BBI608 on murine colorectal cancer cells

Abouzar Babaei, Hoorieh Soleimanjahi, Masoud Soleimani, Ehsan Arefian
Journal PapersDARU Journal of Pharmaceutical Sciences , 2020 August 15, {Pages 11-Jan }

Abstract

BackgroundMany types of oncolytic viruses (OVs) were enrolled in clinical trials. Recently, an OV named Talimogene laherparepvec approved for the treatment of melanoma. This achievement highlighted the clinical application of OVs. Scientists focus on using these anticancer agents in combination with the current or/and new anticancer chemotherapeutics. They aim to increase the oncolytic effect of a new approach for the treatment of cancer cells.ObjectivesThe present study aimed to assess the anticancer impacts of ReoT3D, irinotecan (CPT-11), and napabucasin (BBI608) against murine colorectal cancer cells (CT26). They are assessed alone and in combination with each other.MethodsHere, oncolytic reovirus was propagated and titrated. Then MTT as

HSV-TK Expressing Mesenchymal Stem Cells Exert Inhibitory Effect on Cervical Cancer Model

Azra Kenarkoohi, Taravat Bamdad, Masoud Soleimani, Hoorieh Soleimanjahi, Ali Fallah, Shahab Falahi
Journal PapersInternational Journal of Molecular and Cellular Medicine , Volume 9 , Issue 2, 2020 January , {Pages 146 }

Abstract

A growing area of research is focused on cancer therapy, and new therapeutic approaches are welcomed. Mesenchymal stem cell (MSC)-based gene therapy is a promising strategy in oncology. Intrinsic tropism and migration to tumor microenvironment with off lights are attractive features of this type of cell carrier. In this way, suicide genes have also found a good platform for better performance and have shown a stronger anti-tumor mechanism by riding on mesenchymal cells. In this study, we investigated the anti-tumor activity of intratumoral injected MSCs transduced with a lentivector expressing the HSV/TK in a mouse cervical cancer model. Following the injection of MSCs transduced with lentivector carrying TK, MSCs alone or PBS into the mice

The evaluation of viral fusion proteins structure and mechanism in different viruses

Roya Kianfar, Hoorieh Soleimanjahi
Journal PapersPathobiology Research , Volume 23 , Issue 3, 2020 July 10, {Pages 0-0 }

Abstract

Conclusion: The changes in fusion protein in the levels before and after fusion, description of fusion proteins in viruses such as Influenza, Filo, and Reoviruses as a prototype of fusion protein viruses and their therapeutic applications of fusion protein as a potential drugs such as Lactoferrin and Enfuvertide in preventing the occurrence of fusion phenomenon is important issue for consideration about multiplication and virus entry.

Lack of human coronaviruses in patients with upper respiratory tract infections symptoms

Somayeh Alipour, Hoorieh Soleimanjahi, Fatemeh Fotouhi
Journal Papersمجله ویروس شناسی ایران , Volume 14 , Issue 1, 2020 June 10, {Pages 0-0 }

Abstract

OBJECTIVE: Coronaviridae family cause respiratory diseases ranging from common cold to severe Respiratory diseases such as SARS, MERS and new emerging coronavirus disease COVID-19. Also the family including four other human coronaviruses (HCoV-229E, HCoV-HKU1, HCoV-NL63, and HCoV-OC43) with flu likes symptoms. Coronaviruses cannot be distinguished clinically from other respiratory infectious agents. Based on the health importance and widespread distribution of respiratory infections, the current study was designed for diagnosis of Pancoronaviruses.MATERIALS AND METHODS: Nasopharyngeal swabs from 200 patient suspected viral upper respiratory tract infection analyzed using optimized RT-PCR assay. The constructive specific degenerate primers w

Distribution of the most common types of HPV in Iranian women with and without cervical cancer

Zohreh Farahmand, Hoorieh Soleimanjahi, Masoud Garshasbi, Malihe Hasanzadeh, Ehsan Zafari
Journal PapersWomen & Health , 2020 September 23, {Pages 10-Jan }

Abstract

Cervical cancer is an important cause of death in women worldwide. About 99.7% of all cervical cancers have been related to human papillomavirus, especially types 16 and 18. Types 6 and 11 cause genital warts. We aimed to determine the prevalence of common HPV genotypes among women in the general population and women with cervical cancer. A total of 571 healthy women cytology specimens and 113 tissue samples of cervical cancer were investigated using HPV type-specific primers. HPV DNA was detected in 24% of healthy women: 3.3% were positive for high-risk HPV and 11.6% for low-risk HPV. HPV6 (9.3%) had the highest prevalence followed by HPV11 (2.3%), HPV16 (1.8%), HPV18 (1.2%), and 9.1% of samples were positive for unknown types

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