- BS/BA: Biology
- MS: Biochemistry
- PhD: Biochemistry
- Phone: 82883428
- Fax:
- Email: khajeh@modares.ac.ir
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Name: Khosro Khajeh Professor Biochemistry Department Faculty of Biological Science Tarbiat Modares University, P.O. Box: 14115-175
Phone: 82884717 Mobile: 09123157174 Email: khajeh@modares.ac.ir and khajeh_k@yahoo.com
Education 1374-1380 University of Tehran, IBB * Ph. D. Biochemistry 1370-1374 University of Tehran, IBB * M. S. Biochemistry 1366-1370 University of Shiraz * B.S. Biology Language: English
Graduate Student Advisor 2000-2005, Tarbiat Modares University 15 Master and 3 Ph. D. students
Lecturer, Tarbiat Modares University
Projects: 1) Use of antibodies for stabilization of α-amylase 2) Isolation, purification and cloning of laccase, protease and glucose isomerase from microorganisms of hot spring 3) Purification of FMN-NADH oxidoreductase from a new bacterial sp. 4) Biosensor for phenolic compounds 5) Identification and determination of pollutants in the soil 6) Bioremediation of the soil pollutants Gene discoveries
1) Geobacillus sp. LH8 16S ribosomal RNA gene, partial sequence
2) Bacillus sp. HR-08 16S ribosomal RNA gene, partial sequence
3) Bacillus sp. KR-8104 alpha-amylase precursor, gene, partial cds
4) Bacillus sp. HR03 16S ribosomal RNA gene, partial sequence
5) Geobacillus sp. LH8 thermostable DNA polymerase I (polI) gene, complete cds
6) Geobacillus sp. MKK-2005 16S ribosomal RNA gene, partial sequence
7) Bacillus sp. STG-83 16S ribosomal RNA gene, partial sequence
8) Geobacillus sp. L14 16S ribosomal RNA gene, partial sequence
9) Klebsiella pneumoniae strain TM100 16S ribosomal RNA gene, partial seq.
10) Bacillus sp. WHO 16S ribosomal RNA gene, partial sequence
11) Thermus sp. GH5 16S ribosomal RNA gene, partial sequence Protein discovery
1) Alpha-amylase precursor [Bacillus sp. KR-8104]
2) Bacillus sp. hr08 serine protease gene, partial cds
3) thermostable DNA polymerase I [Geobacillus sp. LH8] 4) Crystal structure of native alpha-amylase from Bacillus sp. KR-8104 PDBID: 3dc0 5)High resolution crystal structure of Bacillus amyloliquefaciens alpha-amylase PDBID: 3bh4
Awards and Honours: Razi Student Award, 1374 Tehran University Award, 1380 Razi Medical Award, 1387
Publications Books: 1) Biology, First edition (publisher: Manshor Danesh) 2) Biology, Second edition (publisher: Manshor Danesh) 3) Translation and final advisor of “Stryer Biochemistry” (publisher: Biology House) 4) Translation and final advisor of “Campbell Biology” (publisher: Biology House) 5) Industrial Enzymology (publisher: University of Tehran) 6) Isolation and purification of proteins, in preparation 7) Translation and final advisor of “Molecular Biology of the Gene, Watson
Abstracts: About 200 abstracts in national and international congresses
Recent Publications:
1) Sadeghi, L., Khajeh, K., Mollania, N., Dabirmanesh, B., Ranjbar, B. Extra EF Hand Unit (DX) Mediated Stabilization and Calcium Independency of α-Amylase. Mol Biotechnol 1-8 , Article in Press. 2) Dabirmanesh, B., Khajeh, K., Ranjbar, B., Ghazi, F., Heydari, A. Inhibition mediated stabilization effect of imidazolium based ionic liquids on alcohol dehydrogenase. J Mol Liq, Article in Press 3) Gill, P., Ranjbar, B., Saber, R., Khajeh, K., Mohammadian, M. Biomolecular and structural analyses of cauliflower-like DNAs by ultraviolet, circular dichroism, and fluorescence spectroscopies in comparison with natural DNA. J Biomol Tech 22 (2012) 60-66 4) Rahimzadeh, M., Khajeh, K., Mirshahi, M., Khayatian, M., Schwarzenbacher, R.Probing the role of asparagine mutation in thermostability of Bacillus KR-8104 α-amylase. Int J Biol Macromol 50 (2012) 1175-1182 5) Haghani, K., Khajeh, K., Naderi-Manesh, H., Ranjbar, B. Evidence regarding the hypothesis that the histidine-histidine contact pairs may affect protein stability. Int J Biol Macromol 50 (2012) 1040-1047 6) Derakhti, S., Shojaosadati, S.A., Hashemi, M., Khajeh, K. Process parameters study of -amylase production in a packed-bed bioreactor under solid-state fermentation with possibility of temperature monitoring. Prep Biochem Biotechnol 42 (2012) 203-216. 7) Ashtari, K., Khajeh, K., Fasihi, J., Ashtari, P., Ramazani, A., Vali, H.Silica-encapsulated magnetic nanoparticles: Enzyme immobilization and cytotoxic study. Int J Biol Macromol 50 (2012) 1063-1069 8) Hashemi, M., Shojaosadati, S.A., Razavi, S.H., Mousavi, S.M., Khajeh, K., Safari, M. The Efficiency of Temperature-Shift Strategy to Improve the Production of α-Amylase by Bacillus sp. in a Solid-State Fermentation System. Food Bioprocess Tech 5 (2012) 1093-1099. 9) Ghiasi, P., Hosseinkhani, S., Noori, A., Nafissi, S., Khajeh, K. Mitochondrial complex I deficiency and ATP/ ADP ratio in lymphocytes of amyotrophic lateral sclerosis patients. Neurol Res 34 (2012) 297-303. 10) Nazari-Robati, M., Khajeh, K., Aminian, M., Fathi-Roudsari, M., Golestani, A. Co-solvent mediated thermal stabilization of chondroitinase ABC I form Proteus vulgaris. Int J Biol Macromol 50 (2012) 487-492. 11) Amini-Bayat, Z., Hosseinkhani, S., Jafari, R., Khajeh, K. Relationship between stability and flexibility in the most flexible region of Photinus pyralis luciferase. Biochimica et Biophysica Acta 1824 (2012) 350-358. 12) Dastgheib, S.M.M., Amoozegar, M.A., Khajeh, K., Shavandi, M., Ventosa, A.Biodegradation of polycyclic aromatic hydrocarbons by a halophilic microbial consortium. Applied Microbiol Biotechnol, In Press. 13) Tohidi MT, Ranjbar B, Khajeh K. Interaction of lysozyme with gold nanorods: conformation and activity investigations, Int J Biol Macromol49 (2011)629-36. 14)Mollania N, Khajeh K, Ranjbar B, Hosseinkhani S. Enhancement of bacterial laccase thermostability through directed mutagenesis of a surface loop, Enzym Microbiol Technol 49 (2011) 446-452. 15) Azizi A, Ranjbar B, Khajeh K. Effects of trehalose and sorbitol on the activity and structure of Pseudomonas cepacia lipase: Spectroscopic insight, Int J Biol Macromol49 (2011)652-6. 16) Yousefi-Nejad Masoumeh; Manesh Hossein Naderi-; Khajeh Khosro. Proteomics of early and late cold shock stress on thermophilic bacterium, Thermus sp. GH5. J proteomics 74 (2011) 2100-11. 17)Dabirmanesh B, Khajeh K, Akbari J, Mesophilic alcohol dehydrogenase behavior in imidazolium based ionic liquids. J Mol Liquids 161(2011) 139-143. 18) Karimeh H, Khajeh K, Salmanian AH, Ranjbar B, Bakhtiyari S. Acid-Induced Formation of Molten Globule States in the wild type Escherichia coli 5-Enolpyruvylshikimate 3-Phosphate Synthase and its three mutated forms: G96A, A183T and G96A/A183T.Protein J 30 (2011) 132–137. 19) Hemmat, J., Yakhchali, B., Khajeh, K., Moosavi-Movahedi, A.A., Karkhane, A.A. Overexpression of full-length core protein of hepatitis C virus by Escherichia coli cultivated in stirred tank fermentor. Iranian J Biotechnol 9 (2011) 245-252. 20) Dabirmanesh B, Daneshjou S, Akhavan Sepahi A, Ranjbar B, Khavarinejad RA, Gill P, Hydari A, Khajeh K. Effect of ionic liquids on the structure, stability and activity of two related α- amylases. Int J Biol Macromol 48 (2011) 93-97. 21) Kazemi SH, Khajeh K. Electrochemical studies of a novel Biosensor Based on the nanoparticles coated with horseradish peroxidase to determine the concentration of phenolic compounds. J Iran chem soc 8 (2011) 152-160. 22) Haghani K, Khajeh K, Salmanian AH, Ranjbar B, Bakhtiary S. Acid – induced of molten Globule state in the wild type Escherichia coil 5- enolpyruvylshikimate 3-phosphate synthase and its three mutated forms: G96A, A183T and G96A/ A183T. Protein J 30 (2011) 132-137. 23) Dastghieb SMM, Amoozagar MA, Khajeh K, Ventosa A. A holtolerant Alcanivorax sp strain with potential application in saline soil remediation. Applied microbiol biotechnol 90 (2011) 305-312. 24) Asad S, Torabi SF, Fathi-Roudsari M, Ghaemi N, Khajeh K. Phosphat buffer effects on thermal stability and H202-resistance of horseradish peroxidase. Int J Biol Macromol 48(2011) 566-570. 25) Asad S, Khajeh K, Ghaemi N. Investigating the structural and functional affected of mutating Asn glycosylation sites of horseradish peroxidase to Asp. Applied Biochem Biotechnol 164 (2011) 454-463. 26) Akbari N, Daneshjoo S, Akbari J, Khajeh K. Isolation, characterization, and catalytic properties of a novel lipase which is activated in ionic liquids and organic solvents. Applied Biochem Biotechnol 165 (2011) 785-794. 27) Daneshjoo S, Akbari N, Sepahi AA, Ranjbar B, Khavrinejad RA, Khajeh K. Imidazolium chloride-based ionic liquid –assisted improvement of lipase activity in organic solvent, 11(2011) 259-263. 28) Gill P, Ranjbar B,Saber R,Khajeh K,Mohammadian M. Biomolecular and Structural Analyses of Cauliflower-like DNAs by Ultraviolet, Circular Dichroism, and Fluorescence Spectroscopies in Comparison with Natural DNA. J Bio Mol Tech 22 (2011) 60-66. 29) Hashemi, M., Shojaosadati, S.A., Razavi, S.H., Mousavi, S.M., Khajeh, K., Safari, M. The Efficiency of Temperature-Shift Strategy to Improve the Production of α-Amylase by Bacillus sp. in a Solid-State Fermentation System. Food and Bioprocess Tech (2010) 1-7.
30) Asghari SM, Pazhang P, Ehtesham S, Karbalaei-Heidari HR, Taghdir M, Sadeghizadeh M, Naderi-Manesh H and Khajeh K. Remarkable improvements of a neutral protease activity and stability share the same structural origins. PEDS (2010) 1-8.
31) Moradzadegan A, Ranaei-siadat SO, Ebrahim-Habibi A, Barshan M, Jalili R, Torabi SF, Khajeh K. Immobilization of acetylcholinesterase in nanofibrous PVA/BSA membranes by Electrospinning. Eng Life Sci 10 (2010) 57-64. 32) Aminzadeh S, Naderi-Manesh H, Khajeh K, Ranjbar B, Farrokhi N. Chracterization of acid- induced partially folded conformation resembling a molten Globule state of polygalacturonase from a filamentous fungus tetracoccosporium sp. Applied Biochem Biotecnol 160 (2010) 1921-1932. 33) Alikhajeh J, Khajeh K, Ranjbar B, Naderi-Manesh H, Lin Y.-H, Liu E, Guan H.-H, Hsieh Y.-C, Chuankhayan P, Huang Y.-C, Jeyaraman J, Liu M.-Y, Chen C.-J. Structure of Bacillus amyloliquefaciens -amylase at high resolution: implications for thermal stability. Structural Biology and Crystallization Communications 66 (2010) 121-129. 34) Mollania N, Khajeh K, Hosseinkhani S, Dabirmanesh B. Purification and characterization of a thermostable phytate resistant α-amylase from Geobacillus sp. LH8. Int J Biol Macromol 46 (2010) 27-36. 35) Akbari N, Khajeh K, Rezaie S, Mirdamadi S, Shavandi M, Ghaemi N. High- level expression of lipase in Escherichia coli and recovery of active recombinant enzyme through in vitro refolding. Protein Expres Pur 70 (2010) 1, 75-80. 36) Akbari N, Kajeh k, Ghaemi N, Salemi Z, Efficiont refolding of recombinant lipase from Escherichia coil inclusion bodies by response surface methodology. Protein Expres pur 70 (2010) 254-259. 37) Ghollasi M, Khajeh K, Naderimanesh H, Ghasemi A. Engineering of Bacillus alpha-Amylase with improved Thermostability and calcium indepenency. Applied Biochem Biotechnol 162 (2010) 444-459. 38) Ahmadi A, Ghobadi S, Khajeh K, Nomanpour B, Dalfard AB. Purification of alpha- amylase from Bacillus sp GHA1 and its partial characterization. J Iran Chem Soc 7(2010) 432-440. 39) Badoei-dalfard,A. Khajeh.K, Asghari SM, Ranjbar B, Karbalaei HR. Eenhanced activity and stability in the presence of organic solvents by increased active site polarity and stabilization of a surface loop in a metalloprotease. J Biochem 148 (2010) 231-238. 40) Shavandi M, Sadeghizadeh M, Khajeh K, mohebali GH, Zomorodipour A. Genomic structure and promoter analysis of the dsa operon for dibenzothiophene biodesulfurization from Gordonia alkanivoration from Gordonia alkanivorans RIP90A. Appl microbial biotechnol 87(2010) 1455-1461. 41) Mohammadian M, FathiRoudsari M, Mollania N, Badoei-Dalfard A, Khajeh K. Enhanced expression of a recombinant bacterial laccase at low temperature and micro aerobic condition: purification and biochemical characterization . J Ind Microbiol Biotechnol 37(2010) 863-869. 42) Pazhang M, Khajeh K, Asghari SM, Falahati H, Naderimanesh H. Cloning, Expression, and characterization of a novel Methylglyoxal synthase from Thermus sp Strain GH5. Appl biochem biotechnol 162(2010) 1519-1528. 43) Zeinoddini M, Khajeh K, Behzadian F, Hosseinkhani S, saeedinia AR, Barjesteh H. Desing and characterization of an Aequorin – based Bacterial biosensor for detection of toluene and related compounds. J Photochem photobiol 86 (2010) 1071-1075. 44) Gholivand K, Farshadian S, Hosseini Z, Khajeh K, Akbari N. Two novel diorganotin phosphonic diamides: syntheses, crystal atructures,spectral propertiesand in vitro antibacterial studies. Appl Organomet Chem 24 (2010) 700-707. 45) Hashemi M, Razavi SH, Shojaosadati SA, Mousavi SM, Khajeh K, Safari M.Development of a solid-state fermentation process for production of an alpha amylase with potentially interesting properties. J Biosci Bioeng 110 (2010) 333-337. 46) Aminzadeh S, Naderi-Manesh H, Khajeh K, Ranjbar B, Farrokhi N. Characterization of Acid-Induced Partially Folded Conformation Resembling a Molten Globule State of Polygalacturonase from a Filamentous Fungus Tetracoccosporium sp. Appl Biochem Biotechnol 160(2010) 2921-1932. 47) Zareian S, Khajeh K, Ranjbar B, Dabirmanesh B, Ghollasi M, Mollania N. Purification and characterization of a novel amylopullulanase that converts pullulan to glucose, maltose, and maltotriose and starch to glucose and maltose. Enzyme Microb Technol 46 (2009) 57-63. 48) Ataei F, Hosseinkhani S, Khajeh K. Luciferase protection against proteolytic degradation: A key for improving signal in nano-system biology. J Biotechnol 144(2009) 83-88. 49) Ataei F, Hosseinkhani S, Khajeh K. Limited proteolysis of luciferase as a reporter in nanosystem biology: a comparative study.Photochem Photobiol 85 (2009) 1162-1167. 50) Yazdani M, Naderi-Manesh H, Khajeh K, Soudi MR, Asghari SM, Sharifzadeh M. Isolation and characterization of a novel gamma-radiation-resistant bacterium from hot spring in Iran. J Basic Microbiol 49(2009) 119-27. 51) Akbari N, Khajeh K, Ghaemi N, Salemi Z. Efficient refolding of recombinant lipase from Escherichia coli inclusion bodies by response surface methodology.Protein Expr Purif 70 (2009) 254-259. 52) Khajeh K, Asghari M, Pazhang M, Ehtesham S, Karbalaei-Heidari HR, Taghdir M. Remarkable improvements of enzyme activity and stability share the same structural origins. N Biotechnol 25 (2009) Page S142. 53) Etezad SM, Khajeh K, Soudi M, Tajer Mohammad Ghazvini P, Dabirmanesh B. Evidence on the presence of two distinct enzymes responsible for the reduction of selenate and tellurite in Bacillus sp. STG-83.Enzyme Microb Technol 45(2009) 1-6. 54) Moradian F, Khajeh K, Naderi-Manesh H, Sadeghizadeh M. Isolation, purification and characterization of a novel thermostable alkaline serine protease resistance to surfactant and active in organic solvent. Appl Biochem Biotechnol 159 (2009) 33-45. 55) Shavandi M, Sadeghizadeh M, Zomorodipour AR, Khajeh K, Biodesulfurization of dibenzothiophene by recombinant Gordonia alkanivorans RIPI90A. Bioresource Technol 100 (2009) 475-479. 56) Soudi MR, Mohammad Ghazvini PT, Khajeh K, GharaviS. Bioprocessing of seleno-oxyanions and tellurite in a novel Bacillus sp. strain STG-83: A solution to removal of toxic oxyanions in presence of nitrate. J Hazard Mater 165 (2009) 71-77. 57) Nasiripourdori A, Naderi-Manesh H, Ranjbar B, Khajeh K. Co-solvent Effects on Structure, Function Properties of Savinase: Solvent Induced Thermal Stabilization.Int J Biol Macromol 44 (2009) 311-315. 58) Maroufi B, Ranjbar B, Khajeh K, Naderi-Manesh H, Yaghoubi H. Structural studies of hen egg-white lysozyme dimer: Comparison with monomer. Biochem BiophysActa1784 (2008) 1043-1049. 59) Ghalanbor Z, Ghaemi N, Marashi SA, Amanlou M, Habibi-Rezaei M, Khajeh K. Ranjbar B.Binding of Tris to Bacillus licheniformis alpha-amylase can affect its starch hydrolysis activity. Protein Pept Lett 15 (2008) 212-214. 60) Haghani K, Salmanian AH, Ranjbar B, Zakikhan-Alang K and Khajeh K. Comparative studies of wild type Escherichia coli 5-enolpyruvylshikimate 3-phosphate synthase with three glyphosate-insensitive mutated forms: Activity, stability and structural characterization. Biochem Biophys Acta 1784 (2008) 1167-1175. 61) Mortazavi M, Hosseinkhani S, Khajeh K, Ranjbar B, Emamzadeh AR.Spectroscopic and functional characterization of Lampyris turkestanicus luciferase: a comparative study. Acta Biochim Biophys 40 (2008) 365-74. 62) Amoozegar MA, Salehghamari E, Khajeh K, Kabiri M, Naddaf S.Production of an extracellular thermohalophilic lipase from a moderately halophilic bacterium, Salinivibrio sp. strain SA-2. J Basic Microbiol.48 (2008)160-167. 63) Parsaie S, Shariatmadari F, Zamiri MJ, Khajeh K. Influence of wheat-based diets supplemented with xylanase, bile acid and antibiotics on performance, digestive tract measurements and gut morphology of broilers compared with a maize-based diet. Br Poult Sci 48 (2007) 594-600. 64) Khalaj-Kondori M, Sadeghizadeh M, Khajeh K, Naderi-Manesh H, Ahadi AM, Emamzadeh A. Cloning, sequence analysis and three-dimensional structure prediction of DNA pol I from thermophilic Geobacillus sp. MKK isolated from an Iranian hot spring. Appl Biochem Biotechnol 142 (2007) 200-208. 65) Alikhajeh J, Khajeh K, Naderi-Manesh M, Ranjbar B, Naderi-Manesh H and Sajedi RH. Kinetic analysis, structural studies and prediction of pKa values of Bacillus KR-8104 α-amylase: the determinants of pH-activity profile. Enzyme Microb Technol 41(2007) 337-345. 66) Ghasemi A., Khajeh K and Ranjbar B. Stabilization of Bacillus licheniformis alpha-amylase by specific antibody which recognizes the N-terminal fragment of the enzyme. Int J Biol Macromol 41 (2007) 162-167. 67) Torabi SF, Khajeh K, Ghasempur S, Ghaemi N and Ranaei SO. Covalent attachment of cholesterol oxidase and horseradish peroxidase on perlite through silanization: activity, stability and co-immobilization. J Biotechnol 131(2007) 111-120. 68) Ghasempur S, Torabi SF, Ranaei SO, Jalali Heravi M, Ghaemi N an Khajeh K. Modeling and optimization of peroxidase-catalyzed oxidative coupling process for phenol removal from aqueous phase using response surface methodology. Environ Science Technol 41(2007) 7073-7079. 69) Sajedi RH, Taghdir M, Naderi-Manesh H, Khajeh K, Ranjbar B.Nucleotide sequence, structural investigation and homology modeling studies of a Ca2+-independentalpha-amylase with acidic pH-profile. J Biochem Mol Biol 40 (2007) 315-24. 70) Rooki H, Khajeh K, Mostafaie A, Kashanian S, Ghobadi S.Partially Folded Conformations of Bovine Liver Glutamate Dehydrogenase Induced by Mild Acidic Conditions. J Biochem 142 (2007) 193-200. 71) Zandi K, Farsangi MH, Nabipour I, Soleimani M, Khajeh K, Sajedi RH and Jafari SM. Isolation of a 60 kDa protein with in vitro anticancer activity against human cancer cell lines from the purple fluid of the Persian Gulf sea hare, Aplysia dactylomela. Afr J Biotechnol 6 (2007) 1280-1283. 72) Yaghoobi H, Khajeh K, Hosseinkhani S, Ranjbar B, Naderi-Manesh H. Application of zero-length cross-linking to form lysozyme, horseradish peroxidase and lysozyme- peroxidase dimers: activity and stability. Int J Biol Macromol41(2007) 624-30. 73) Moradian F, Khajeh K, Naderi-Manesh H, Ahmadvand R, Sajedi RH, Sadeghizadeh M. Isolation, production and characterization of alkaline proteases from Bacillus sp. HS-08 and KR-8102. Appl Biochem Biotechnol 134 (2006) 77-87. 74) Khajeh K, Monsef Shokri M, Asghari M, Ghasemi A, Moradian F, Ranjbar B, Sadeghi M, Hosseinkhani S, Naderi-Manesh H. Acidic and proteolytic digestion of thermophilic and mesophilic α-amylases: stability and flexibility analysis. Enzyme Microbial Technol 38 (2006) 422-428. 75) Badoei Dalfard A, Khajeh K, Soudi M, Naderi-Manesh H, Ranjbar B. Isolation and biochemical characterization of laccase and tyrosinase activities in a novel melanogenic soil bacterium. Enzyme microbial Technol 39 (2006)1409-1416. 76) Hassani L, Ranjbar B, Khajeh K, Naderi-Manesh H, Naderi-Manesh M and Sadeghi M. Horseradish peroxidase Thermostabilization: The combinatorial effects of the surface modification and the polyols. Enzyme Microbial Technol 38 (2006) 118-125. 77) Gholivand K, Mojahed F, Salehi M, Naderi-Manesh H and Khajeh K. Synthesis, characterization and toxicity properties of two oxono and thino analogues of phosphoramidate compounds. J Enzyme Inhib Med Chem 21 (2006) 521-525. 78) Habibi A, Khajeh K, Ranjbar B, Naderi-Manesh H and Nenat-Gorgani M. Thermostabilization of Bacillus amyloliquefaciens α-amylase by chemical crosslinking. J Biotechnol 123 (2006) 434-442. 79) Monsef M, Khajeh K, Hosseinkhani S, Ranjbar B. Comparison of the molten globule states of thermophilic and mesophilic α-amylases. Biophys Chem 122 (2006) 58-65. 80) Mirshahi M, Shamsipour F, Mirshahi T, Khajeh K and Naderi-Manesh H. A novel monoclonal antibody with catalytic activity against beta human chorionic gonadotropin. Immunol Lett 106 (2006) 57-62. 81) Pazhang M ,Khajeh K , Hossenkhani S ,Ranjbar B. Effects of water-miscible solvents and polyhydroxy compounds on the structure and enzymatic activity of thermolysin. J Biotechnol 127 (2006) 45-53. 82) Gholivand K, Alizadegan AM, Firooz AA, Khajeh K, Naderi-Manesh H, Bijanzadeh H. Anticholinesterase activity of some major intermediates in carbacylamidophosphate synthesis: preparation, spectral characterization and inhibitory potency determination. J Enzyme Inhib Med Chem 2 (2006) 105-11. 83) Aminzadeh S, Naderi-Manesh H, Khajeh K and Naderi-Manesh M. Purification, Characterization, Kinetic Properties and Thermal Behavior of the Extracellular Polygalacturonase Produced by a Filamentous Fungus Tetracoccosporium sp. Appl Biochem Biotechnol 135 (2006) 193-208. 84) Gholivand K , Shariatinia Z. , Khajeh Z , Naderi-Manesh H . Synthesis and spectroscopic characterization of some phosphoramidates as reversible inhibitors of human acetylcholinesterase and determination of their IC50 values. J Enzyme Inhib Med Chem 2 (2006) 31-35. 85) Sajedi RH , Naderi-Manesh H , Moradian F, Khajeh K , Ahmadvand R , Ranjbar B , Asoodeh A. A Ca-independent α-amylase that is active and stable at low pH from the Bacillus sp. KR-8104. Enzyme Microbial Technol 36 (2005) 666-671.
86) Jafari-Aghdam J, Khajeh K , Ranjbar B, Nemat-Gorgani M.Deglycosylation of glucoamylase from Aspergillus niger: effects on structure, activity and stability. Biochim Biophys Acta 1750 (2005) 61-8. 87) Madvar AR, Hosseinkhani S, Khajeh K , Ranjbar B, Asoodeh A.Implication of a critical residue (Glu175) in structure and function of bacterial luciferase. FEBS Lett 579 (2005) 4701-6. 88) Sadat Hayatshahi SH, Abdolmaleki P, Safarian S, and KhajehK . Non-linear quantitative structure–activity relationship for adenine derivatives as competitive inhibitors of adenosine deaminase. Biochem. Biophys. Research comun 338 (2005) 1137-1142. 89) S. Mohsen Asghari, Khajeh K , Moradian F , Ranjbar B, Naderi-Manesh H , Acid-induced conformational changes in Bacillus amyloliquefaciens α-amylase:appearance of a molten globule like state. Enzyme Microbial Technol 35 (2004) 51. 90) Mohsen Asghari S , Khajeh K , Ranjbar B , Sajedi R, Naderi-Manesh H , Comparative studies on trifluoroethanol (TFE) state of a thermophilic α-amylase and its mesophilic counterpart: limited proteolysis, conformational analysis, aggregation and reactivation of the enzymes. Int J Biol Macromol 34 (2004) 173. 91) Karbalaei-Heidari HR, Habibi AE, Khajeh K , Ranjbar B, Nemat-Gorgani M. Interaction of an intermediate structure of Bacillus subtilis alpha-amylase with alkyl-substituted sepharose 4B: a model of membrane translocation. Appl Biochem Biotechnol 117 (2004) 123. 92) Ebrahim Habibi A , Khajeh K , Nemat-Gorgani M . Chemical modification of lysine residues in Bacillus licheniformis α-amylase: conversion of an endo- to exo-type enzyme. J Biochem Mol Biol 37 (2004) 5. 93) Sajedi RH , Naderi-Manesh H , Khajeh K , Ranjbar B , Ghaemi N , Naderi-Manesh M . Purification, characterization and structural investigation of a new extracellular α-amylase fro Bacillus sp. TM1: moderate thermophile and partially calcium-dependent. Appl Biochem Biotechnol 119 (2004) 41-50. 94) Gholivand K , Shariatinia Z , Ghadimi S , Mojahed F , Madani Alizadegan A, Khajeh K , Naderi-Manesh H . Acetylcholinesterase inhibition by diaza- and dioxophosphole compounds:synthesis and determination of IC 50 values. J Enzym Inhib Med Chem 19 (2004) 403-407. 95) Khajeh K , Ranjbar B, Naderi-Manesh H, Ebrahim Habibi A, Nemat-Gorgani M.Chemical modification of bacterial alpha-amylases: changes in tertiary structures and the effect of additional calcium. Biochim Biophys Acta 1548 (2001) 229-37. 96) Khajeh K, Khezre-Barati S, Nemat-Gorgani M.Proteolysis of mesophilic and thermophilic alpha-amylases: a comparative study. Appl Biochem Biotechnol 94 (2001) 97-109. 97) Khajeh K , Naderi-Manesh H, Ranjbar B, Moosavi-Movahedi A, Nemat-Gorgani M.Chemical modification of lysine residues in Bacillus alpha-amylases: effect on activity and stability. Enzyme Microb Technol 28 (2001) 543-549. 98) Khajeh K , Nemat-Gorgani M.Comparative studies on a mesophilic and a thermophilic alpha-amylase. Appl Biochem Biotechnol 90 (2001) 47-55. |