Medical Sciences

Personal Information

 

Given Name: Mohammad 
Family Name: Javan
Nationality: Iranian

Birth Year: 1971
Gender: Male
Marital status: Married 


            
Address and position

Associate professor,
Dept. Physiology
School of Medical Sciences
Tarbiat Modares Univ. 
Tehran, Iran
P.O.Box: 14115-331
Fax: +98-21-82884555
Tel:  +98-21-82884522
E-mail: mjavan@modares.ac.ir
Web page: www.modares.ac.ir/~mjavan


Academic Background

2003-2004    Post-doctoral Fellow in Molecular Pharmacology, Dept. Pharmacology and Toxicology, Kyorin University School of Medicine, Shinkawa, Mitaka, Tokyo, Japan.
1998-2003    Ph.D. Student in Medical Physiology, Dept. Physiology, Neuroscience Research Center,  Shaheed Beheshti Univ. Med. Sci., Tehran, Iran
1994-1997 M.Sc. Student in Physiology, Dept. Biology, Shaheed Beheshti Univ., Tehran, Iran.
1990-1994 B.Sc. Student in Biology, Dept. Biology, Mashhad Univ., Mashhad, Iran.
-1990     High School Diploma, Maftouhi High School, Bardaskan, Khorasan Razavi, Iran.
      
Extracurricular Courses

1)    Work Shop of Functional Genomic, IBRO School of Brain Functions, Hong Kong Univ. Hong Kong, Dec. 2000.
2)    Work Shop of Molecular Biology, Shaheed Beheshti Univ. Med. Sci., Tehran, May 2000.
3)    Work shop of Electrophysiology, Neuroscience Research Center, Shaheed Beheshti Univ. Med. Sci., Tehran, Sep. 2002.
4)    Work Shop of Molecular Biology and Recombinant Proteins, National institute for Genetic and Biotechnology, Tehran, Jun. 2003.
5)    Work Shop of Cloning and Hybridization, Research Center for Cellular and Molecular Biology, Shaheed Beheshti Univ. Med. Sci., Tehran, Feb. 2003.




Honors
1)    First ranked student, 2nd festival of research, Shahid Beheshti Univ. Med. Sci. 2001, Tehran, Iran.
2)    Best Presentation Award, Second Annual meeting of the Iranian Pain Society, 2-3 May 2002. Tehran, Iran.  
3)    Best presentation Award, 5th congress of Federation of Asian- Oceanian Neuroscience Societies (FAONS), Lucknow, India, 2010, 25-28 Nov. 

Membership of Scientific Societies
1.    International Brain Research Organization (IBRO)
2.    Iranian Society of Physiology and Pharmacology (Council Member)
3.    Iranian Cell Death Society (Council Member)
4.    Iranian Neuroscience Society
5.    Japanese Pharmacological Society



Publications

 

1.     Mohajeri M, Sadeghizadeh M, Najafi F, Javan M Polymerized Nano-curcumin attenuates neurological symptoms in EAE model of multiple sclerosis through down regulation of inflammatory and oxidative processes and enhancing neuroprotection and myelin repair. Neuropharmacology. 2015 Jul 23. doi: 10.1016/j.neuropharm.2015.07.013.

2.     Ghasemi-Kasman M, Hajikaram M, Baharvand H, Javan M. MicroRNA-Mediated In Vitro and In Vivo Direct Conversion of Astrocytes to Neuroblasts. PLoS One. 2015 Jun 1;10(6):e0127878.

3.     Dokanehiifard S, Soltani BM, Parsi S, Hosseini F, Javan M, Mowla SJ. Experimental verification of a conserved intronic microRNA located in the human TrkC gene with a cell type-dependent apoptotic function. Cell Mol Life Sci. 2015 Jul;72(13):2613-25. doi: 10.1007/s00018-015-1868-4. Epub 2015 Mar 14.

4.     Dehghan S, Asadi S, Hajikaram M, Soleimani M, Mowla SJ, Fathollahi Y, Ahmadiani A, Javan M. Exogenous Oct4 in combination with valproic acid increased neural progenitor markers: an approach for enhancing the repair potential of the brain. Life Sci. 2015 Feb 1;122:108-15. doi: 10.1016/j.lfs.2014.12.007. Epub 2014 Dec 19.

5.     Pourabdolhossein F, Mozafari S, Morvan-Dubois G, Mirnajafi-Zadeh J, Lopez-Juarez A, et al. Nogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm. PLoS ONE 9(9): e106378. doi:10.1371/journal.pone.0106378.

6.     Movaghar B, Tiraihi T, Javan M, Taheri T, Kazemi H. Induced bone marrow stromal cells into Schwann cells by progesterone improved the outcome of transected sciatic nerve model. J Neurosurg Sci. 2015 May 12. [Epub ahead of print].

7.     Mahdieh Azin, M.Sc., Javad Mirnajafi-Zadeh, Ph.D., Mohammad Javan, Fibroblast Growth Factor-2 Enhanced The Recruitment of Progenitor Cells and Myelin Repair in Experimental Demyelination of Rat Hippocampal Formations. Cell J. 2015; 17(3): 540-546.

8.     Kaeidi A, Azizi H, Javan M, Ahmadi Soleimani SM, Fathollahi Y, Semnanian S. Direct Facilitatory Role of Paragigantocellularis Neurons in Opiate Withdrawal-Induced Hyperactivity of Rat Locus Coeruleus Neurons: An In Vitro Study. PLoS One. 2015 Jul 31;10(7):e0134873

9.     Asadi S, Dehghan S, Hajikaram M, Mowla SJ, Ahmadiani AA, Javan M. Comparing The Effects of Small Molecules BIX-01294, Bay K8644, RG-108 and Valproic Acid, and Their Different Combinations on Induction of Pluripotency Marker-Genes by Oct4 in The Mouse Brain. Cell J. 2015 Winter;16(4):416-25. Epub 2015 Jan 13.

10. Parvini M, Satarian L, Parivar K, Javan M, Tondar M, Ahmad S, Baharvand H. (2014) Human pluripotent stem cell-derived retinal pigmented epithelium in retinal treatment: from bench to bedside. Mol Neurobiol 2014 Oct;50(2):597-612. doi: 10.1007/s12035-014-8684-y. Epub 2014 Apr 3.

11. Satarian L, Javan M, Kiani S, Hajikaram M, Mirnajafi-Zadeh J, Baharvand H. Engrafted human induced pluripotent stem cell-derived anterior specified neural progenitors protect the rat crushed optic nerve. PLoS One. 2013 Aug 19;8(8):e71855. doi: 10.1371/journal.pone.0071855. eCollection 2013.

12. Pazhoohan S, Satarian L, Asghari AA, Salimi M, Kiani S, Mani AR, Javan M. Valproic Acid attenuates disease symptoms and increases endogenous myelin repair by recruiting neural stem cells and oligodendrocyte progenitors in experimental autoimmune encephalomyelitis. Neurodegener Dis. 2014;13(1):45-52. doi: 10.1159/000352021. Epub 2013 Aug 16.

13. Bakhtiari N, Soulemani M, Javan M, Hemmati R, Hosseinkhani S. Ursolic acid induces myoglobin expression and skeletal muscle remodeling in mice. Published by Iranian society of Physiology and Pharmacology. Volume 18, Number 4 (Winter 2014)

14. Mousavi Y, Azizi H, Mirnajafi-Zadeh J, Javan M, Semnanian S. Blockade of orexin type-1 receptors in locus coeruleus nucleus attenuates the development of morphine dependency in rats. Neurosci Lett. 2014 Aug 22;578:90-4. doi: 10.1016/j.neulet.2014.06.038. Epub 2014 Jun 24.

15. Safari F, Anvari Z, Moshtaghioun S, Javan M, Bayat G, Forosh SS, Hekmatimoghaddam S. Differential expression of cardiac uncoupling proteins 2 and 3 in response to myocardial ischemia-reperfusion in rats. Life Sci. 2014 Mar 11;98(2):68-74. doi: 10.1016/j.lfs.2013.12.230. Epub 2014 Jan 13.

16. Ahmadirad N, Shojaei A, Javan M, Pourgholami MH, Mirnajafi-Zadeh J. Effect of minocycline on pentylenetetrazol-induced chemical kindled seizures in mice. Neurol Sci. 2014 Apr;35(4):571-6. doi: 10.1007/s10072-013-1552-0. Epub 2013 Oct 15.

17. Nazm Bojnordi M, Movahedin M, Tiraihi T, Javan M, Ghasemi Hamidabadi H. Oligoprogenitor cells derived from spermatogonia stem cells improve remyelination in demyelination model. Mol Biotechnol. 2014 May;56(5):387-93. doi: 10.1007/s12033-013-9722-0.

18. Hajiasgharzadeh K, Tavangar SM, Javan M, Dehpour AR, Mani AR. Does hepatic vagus nerve modulate the progression of biliary fibrosis in rats? Auton Neurosci. 2014 Oct;185:67-75. doi: 10.1016/j.autneu.2014.07.005. Epub 2014 Jul 17.

19. Nazm Bojnordi M, Movahedin M, Tiraihi T, Javan M, Ghasemi Hamidabadi H. Oligoprogenitor Cells Derived from Spermatogonia Stem Cells Improve Remyelination in Demyelination Model. Mol Biotechnol. 2014 May;56(5):387-93. doi: 10.1007/s12033-013-9722-0.

20. Ahmadirad N, Shojaei A, Javan M, Pourgholami MH, Mirnajafi-Zadeh J. Effect of minocycline on pentylenetetrazol-induced chemical kindled seizures in mice. Neurol Sci. 2014 Apr;35(4):571-6. doi: 10.1007/s10072-013-1552-0. Epub 2013 Oct 15.

21. Moradpour F, Naghdi N, Fathollahi Y, Javan M, Choopani S, Gharaylou Z. Pre-pubertal castration improves spatial learning during mid-adolescence in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 1;46:105-12. doi: 10.1016/j.pnpbp.2013.07.005. Epub 2013 Jul 16.

22. Azin M, Goudarzvand M, Mirnajafi-Zadeh J, Javan M. Field potential recording from rat hippocampus provides a functional evaluation method for assessing demyelination and myelin repair. Neurol Res. 2013 Oct;35(8):837-43. doi: 10.1179/1743132813Y.0000000221. Epub 2013 May 14.

23. Davoudi M, Shojaei A, Palizvan MR, Javan M, Mirnajafi-Zadeh J. Comparison between standard protocol and a novel window protocol for induction of pentylenetetrazol kindled seizures in the rat. Epilepsy Res. 2013 Sep;106(1-2):54-63. doi: 10.1016/j.eplepsyres.2013.03.016. Epub 2013 Apr 22.

24. Mongabadi S, Firoozabadi SM, Javan M, Shojaei A, Mirnajafi-Zadeh J. Effect of different frequencies of repetitive transcranial magnetic stimulation on acquisition of chemical kindled seizures in rats. Neurol Sci. 2013 Nov;34(11):1897-903. doi: 10.1007/s10072-013-1401-1. Epub 2013 Apr 2.

25. Asghari AA, Azarnia M, Mirnajafi-Zadeh J, Javan M. Adenosine A1 receptor agonist, N6-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies. J Neurol Sci. 2013 Feb 15;325(1-2):22-8. doi: 10.1016/j.jns.2012.11.008. Epub 2012 Dec 20.

26. Khezri S, Javan M, Goudarzvand M, Semnanian S, Baharvand H. Dibutyryl Cyclic AMP Inhibits the Progression of Experimental Autoimmune Encephalomyelitis and Potentiates Recruitment of Endogenous Neural Stem Cells. J Mol Neurosci. 2013 Oct;51(2):298-306. doi: 10.1007/s12031-013-9959-x. Epub 2013 Jan 19.

27. Alavian F, Hajizadeh S, Bigdeli MR, Javan M. The role of protein kinase c in ischemic tolerance induced by hyperoxia in rats with stroke. EXCLI Journal 2012; 11:188-197.

28. Nazm Bojnordi M, Movahedin M, Tiraihi T, Javan M. Alteration in genes expression patterns during in vitro differentiation of mouse spermatogonial cells into neuroepithelial-like cells. Cytotechnology. 2013 Jan;65(1):97-104. doi: 10.1007/s10616-012-9465-y. Epub 2012 Oct 27.

29. Ali T, Javan M, Sonboli A, Semnanian S. Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats. Daru. 2012 Oct 4;20(1):48. doi: 10.1186/2008-2231-20-48

30. Nazm Bojnordi M, Movahedin M, Tiraihi T, Javan M. A simple co-culture system for generation of embryonic stem like cells from testis. Iran Red Crescent Med J. 2012 Dec;14(12):811-5. doi: 10.5812/ircmj.4051. Epub 2012 Dec 6.

31. Bayat Gh, Hajizadeh S, Javan M, Forouzandeh-Moghadam M, Safari F, Azizi H, Mazloom R. Decreased Uncoupling Protein 2 and 3 (UCP2 and UCP3) mRNA expression by endurance exercise training with and without chronic administration of nandrolone in rat heart. Physiology and Pharmacology, 15 (3), 330-340.

32. Bayat Gh, Hajizadeh S, Javan M, Safari F, Goudarzvand M, Shokri S, Pourkhalili Kh, Alavian F. Effect of exercise and chronic administration of nandrolone decanoate on expression of rat heart sarcolemmal ATP- sensitive potassium channels. Feyz, Journal of Kashan University of Medical Sciences 2012; 16: 102-111.

33. Sadegh M, Fathollahi Y, Javan M, Semnanian S. Tolerance to anti-nociceptive effects of sodium-salicylate and morphine decreases adenosine deaminase activity in the rat hippocampus. Koomesh 2012, 13 (3): 390-396.

34. Alavian F, Hajizadeh S, Bigdeli MR, Bayat Gh, Javan M. Evaluation of UCP2 expression in the phenomenon of ischemic resistance induced by alternating normobaric hyperoxia in a rat model of stroke. Physiology and Pharmacology 16 (1): 54-61.

35. Alavian F, Hajizadeh S, Bigdely MR, Javan M. Effect of intermittent normobaric hyperoxia and PKC activity on blood - brain barrier (BBB) permeability. J Sharekord Univ Med Sci 2012, 14(3): 40-50.

36. Alavian F, Hajizadeh S, Javan M, Bigdeli MR. Evaluation of HIF1αexpression in ischemic tolerance induced by intermittent normobaric hyperoxia in the rat model of stroke. J Sabzevar Univ Med Sci 2012, 19: 287-295.

37. Sherafat MA, Heibatollahi M, Mongabadi S, Moradi F, Javan M, Ahmadiani A. Electromagnetic field stimulation potentiates endogenous myelin repair by recruiting subventricular neural stem cells in an experimental model of white matter demyelination. J Mol Neurosci. 2012 Sep;48(1):144-53. doi: 10.1007/s12031-012-9791-8. Epub 2012 May 17.

38. Dehghan S, Javan M, Pourabdolhossein F, Mirnajafi-Zadeh J, Baharvand H. Basic Fibroblast Growth Factor Potentiates Myelin Repair Following Induction of Experimental Demyelination in Adult Mouse Optic Chiasm and Nerves. J Mol Neurosci. 2012 Sep;48(1):77-85. doi: 10.1007/s12031-012-9777-6. Epub 2012 May 3.

39. Haghani M, Shabani M, Javan M, Motamedi F, Janahmadi M. CB1 Cannabinoid Receptor Activation Rescues Amyloid β-Induced Alterations in Behaviour and Intrinsic Electrophysiological Properties of Rat Hippocampal CA1 Pyramidal Neurons. Cell Physiol Biochem. 2012;29(3-4):391-406. doi: 10.1159/000338494. Epub 2012 Apr 3.

40. Pouya A, Sattarian L, Kiani S, Javan M, Baharvand H. Human Induced Pluripotent Stem Cells Differentiation into Oligodendrocyte Progenitors and Transplantation in a Rat Model of Optic Chiasm Demyelination. PLoS One. 2011;6(11):e27925. doi: 10.1371/journal.pone.0027925. Epub 2011 Nov 18.

41. M. Navidhamidi, S. Semnanian, M. Javan, M. Goudarzvand, K. Rohampour, H. Azizi. Examining the effect of the CaMKII inhibitor administration in the locus coeruleus on the naloxone-precipitated morphine withdrawal signs in rats. Behav Brain Res. 2012 Jan 15;226(2):440-4. doi: 10.1016/j.bbr.2011.09.043. Epub 2011 Oct 10.

42. Ali T, Javan M, Sonboli A, Semnanian S. Antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa Willd. in experimental rat models. Nat Prod Res. 2012;26(16):1529-34. doi: 10.1080/14786419.2011.565284. Epub 2011 Oct 10.

43. Hosseinmardi N, Azimi L, Fathollahi Y, Javan M, Naghdi N. In vivo sodium salicylate causes tolerance to acute morphine exposure and alters the ability of high frequency stimulation to induce long-term potentiation in hippocampus area CA1. Eur J Pharmacol. 2011 Nov 30;670(2-3):487-94. doi: 10.1016/j.ejphar.2011.09.008. Epub 2011 Sep 21.

44.  Sherafat MA, Javan M, Mozafari S, Mirnajafi-Zadeh J, Motamedi F. Castration attenuates myelin repair following lysolecithin induced demyelination in rat optic chiasm: an evaluation using visual evoked potential, marker genes expression and myelin staining. Neurochem Res. 2011 Oct;36(10):1887-95. doi: 10.1007/s11064-011-0510-6. Epub 2011 May 28.

45. Mahdavi S, Gharibzadeh S, Ranjbar B, Javan M. Voltage-gated sodium channel gating modifiers: valuable targets for multiple sclerosis treatment. J Neuropsychiatry Clin Neurosci. 2011 Winter;23(1):E17. doi: 10.1176/appi.neuropsych.23.1.E17.

46. Mozafari S, Javan M, Sherafat MA, Mirnajafi-Zadeh J, Heibatollahi M, Pour-Beiranvand S, Tiraihi T, Ahmadiani A. Analysis of Structural and Molecular Events Associated With Adult Rat Optic Chiasm and Nerves Demyelination and Remyelination; Possible Role for 3rd Ventricle Proliferating Cells. Neuromolecular Med. 2011 Jun;13(2):138-50. doi: 10.1007/s12017-011-8143-0. Epub 2011 Feb 3.

47. Mozafari S, Sherafat MA, Javan M, Mirnajafi-Zadeh J, Tiraihi T. Visual evoked potentials and MBP gene expression imply endogenous myelin repair in adult rat optic nerve and chiasm following local lysolecithin induced demyelination. Brain Res 2010, 1351: 50-56. Brain Res. 2010 Sep 10;1351:50-6. doi: 10.1016/j.brainres.2010.07.026. Epub 2010 Jul 15.

48. Khezri Sh, Javan M, Baharvand H, Semnanian S. Reaction of subventricular zone stem cells to the induction of experimental autoimmue encephalomyelitis in mouse. Physiology and Pharmacology 1390, 15(2): 229-240.

49. Khezri Sh, Javan M, Baharvand H, Semnanian S. The Effect of Systemic Administration of dbcAMP on Neural Stem Cells Migration in EAE Model of Multiple Sclerosis. Journal of Sabzevar University of Medical Sciences, 1390, 18: 179-187.

50. Pourabdolhossein F, Javan M, Mirnajafi-Zadeh J, Dehghan S, Sherafat M, Mozafari S, Ahmadiani A. PKC Mediates endogenous inhibition of myelin repair in the context of local demyelination induced in mice optic chiasm. Feyz J Kashan Univ Med Sci 1389, 14: 369-379.

51. Mozafari S, Sherafat MA, Javan M, Mirnajafi-Zadeh J, Electrophysiological and histological comparison of the processes of demyelination and remyelination in optic chiasm and nerves of male-castrated and female rats. The Modares Semiannual Biological Sciences 1389, 1: 9-20.

52. Namvar S, Mirnajafi-Zadeh J, Javan M, Zeraati M. Investigating the changes in expression of RGS4 and RGS10 proteins in the anticonvulsant effects of low frequency stimulation on perforant path kindling in male adult rats. Physiology and Pharmacology 1389, 14: 234-241.

53. Pourabdolhossein F, Mozafari S, Javan M, Mirnajafizadeh J. Electrophysiological and Histological study of Lysolecithin-Induced Local Demyelination in Adult Mice Optic Chiasm. Physiology and Pharmacology 1389, 14(4): 324-336.

54. Zeraati M, Mirnajafi-Zadeh J, Javan M, Semnanian S, Namvar S. Effect of an endonucleotidase inhibitor on anticonvulsant actions of low-frequency electrical stimulation in perforant path rapid kindling in rats. Physiology and Pharmacology,1389, 14, 115 -126.

55. Khakpay R, Semnanian S, Javan M, Janahmadi M. Is the pain modulatory action of 17β-estradiol in locus coeruleus of male rats mediated by GABAA receptors? Physiology and Pharmacology 1389, 14: 252-261.

56. Kourosh Arami M, Semnanian S, Javan M, Hajizadeh S, Sarihi A. Postnatal developmental alterations in the locus coeruleus neuronal fast excitatory postsynaptic currents mediated by ionotropic glutamate receptors of rat. Physiology and Pharmacology 1389, 14(4): 338-348.

57. J. Ghorbi, M. Javan, V. Sheibani, A. Zarebkohan, Changes in beta 1 and beta 2 integrin genes expression in rat lumbar spinal cord is supportive of the inhibitory effect of chronic pain on the development of tolerance to morphine analgesia.  Physiology and Pharmacology 1389, 14: 94-104.

58. Navidhamidi M, Javan M, Fatholahi Y, Semnanian S. Effect of chronic morphine administration on Ca2+/Calmodulin-Dependent protein kinase IIα activity in rat locus coeruleus and its possible role in morphine dependency. Physiology and Pharmacology 1389, 14: 105-114.

59. Khakpay R, Semnanian S, Javan M, Janahmadi M. The effect of intra-locus coeruleus injection of 17-estradiol on inflammatory pain modulation in male rat. Behav Brain Res. 2010 Dec 25;214(2):409-16. doi: 10.1016/j.bbr.2010.06.012. Epub 2010 Jun 20.

60. Goudarzvand M, Javan M, Mirnajafi-Zadeh J, Mozafari S, Tiraihi T. Vitamins E and D3 attenuate Demyelination and potentiate Remyelination Processes of Hippocampal Formation of Rats following Local Injection of Ethidium Bromide. Cell Mol Neurobiol. 2010 Mar;30(2):289-99. doi: 10.1007/s10571-009-9451-x. Epub 2009 Sep 19.

61. Goudarzvand M, Javan M, Mirnajafi-Zadeh J, Tiraihi T. The effect of combined administration of vitamins E and D3 on the demyelination and remyelination of rat hippocampus. J Sabzevar Univ Med Sci, 2009, 16: 62-71.

62. Ghorbi J, Javan M, Sheibani V. changes in the gene expression of beta1 and beta2 integrin following development of tolerance to analgesic effect of morphine in rats. Yakhteh, 11 (2010) 448-455.

63. Hosseinmardi N, Fathollahi Y, Naghdi N, Javan M. Theta pulse stimulation: A natural stimulus pattern can triggerlong-term depression but fails to reverse long-term potentiation in morphine withdrawn hippocampus area CA1. Brain Res. 2009 Nov 3;1296:1-14. doi: 10.1016/j.brainres.2009.08.020. Epub 2009 Aug 15.

64. Zarebkohan A, Javan M, Satarian L, Ahmadiani A. Effect of chronic administration of morphine on the gene expression level of sodium-dependent vitamin C transporters in rat hippocampus and lumbar spinal cord. J Mol Neurosci. 2009 Jul;38(3):236-42. doi: 10.1007/s12031-009-9203-x. Epub 2009 May 6.

65. Jahanshahi A, Mirnajafi-Zadeh J, Javan M, Mohammad-Zadeh M, Rohani R. The antiepileptogenic effect of electrical stimulation at different low frequencies is accompanied with change in adenosine receptors gene expression in rats. Epilepsia. 2009 Jul;50(7):1768-79. doi: 10.1111/j.1528-1167.2009.02088.x. Epub 2009 Apr 27.

66. Hosseinmardi N, Azimi L, Javan M, Naghdi N, Fathollahi Y. Augmentation of paired pulse index as short-term plasticity due to morphine dependence. Physiology and Pharmacology, 13 (2), 108 – 119.

67. Mohammad-Zadeh M, Mirnajafi-Zadeh J, Fathollahi Y, Javan M, Jahanshahi A, Noorbakhsh S M, Motamedi F. The role of adenosine A1 receptors in mediating the inhibitory effects of low frequency stimulation of perforant path on kindling acquisition in rats. Neuroscience, 2009, 158, 1632-43. doi:10.1016/j.

68. Asadi S, Javan M, Ahmadiani A, Sanati M H. Alternative splicing in the synaptic protein interaction site of rat Cav2.2 (a1B) calcium channels: Changes induced by chronic inflammatory pain. J Mol Neurosci. 2009 Sep;39(1-2):40-8. doi: 10.1007/s12031-008-9159-2. Epub 2009 Jan 6.

69. Sherafat M A, Zarebkohan A, Ghorbi J, Mozafari S, Javan M. The effect of cadmium on tolerance induction to analgesic effects of morphine in rats. Ofoghe-Danesh 2008, 14: 18-26.

70. Jalalvand E, Javan M, Haeri-rohani A, Ahmadiani A. Stress and non-stress mediated mechanisms are involved in pain-induced apoptosis in hippocampus and dorsal lumbar spinal cord in rats. Neuroscience. 2008 Nov 19;157(2):446-52. doi: 10.1016/j.neuroscience.2008.08.052. Epub 2008 Sep 4.

71. Jahanshahi A, Mirnajafi-Zadeh J, Javan M, Mohammad-Zadeh M, Rohani R. Effect of Low-Frequency Stimulation on Adenosine A1 and A2A Receptors Gene Expression in Dentate Gyrus of Perforant Path Kindled Rats. Yakhteh Medical Journal. 2008, 10(2), 87-92.

72. Barabadi Z, Hajizadeh S, Javan M, Erfani B, Heidarianpour A. Investigation on the vasodilatory effect of insulin through KATP channels and NO pathway in the skin vessels of native and diabetic rats. Physiology and Pharmacology. 2008, 11(4), 270 – 275.

73. Satarian L, Javan M, Motamedi F. Changes in gene expression levels of the enzymes involved in biosynthesis and degradation of catecholamines following hronic administration of morphine and pain in rats. Physiology and Pharmacology. 2008, 12(1), 14 – 21.

74. Esmaeili-Mahani S, Javan M, Motamedi F, Ahmadiani A. Post-adrenalectomy changes in the gene expression of specific G-protein subunits involved in morphine sensitization. Neuropeptides. 2008 Apr;42(2):169-75. doi: 10.1016/j.npep.2007.12.002. Epub 2008 Jan 30.

75. Satarian L, Javan M, Fathollahi Y. Epinephrine inhibits analgesic tolerance to intrathecal administrated morphine and increases the expression of calcium–calmodulin-dependent protein kinase IIα. Neuroscience Letters, 2008, 430, 213-217.

76. Amini H, Javan M, Gazerani P, Ghaffari A, Ahmadiani A. Lack of Bioequivalence between Two Aciclovir Tablets in Healthy Subjects. Clin Drug Invest. 2008, 28, 47-53.

77. Esmaeili-Mahani S, Shimokawa N, Javan M, Maghsoudi N, Motamedi F, Koibuchi N, Ahmadiani A. Low-dose morphine induces hyperalgesia through activation of G(alphas), protein kinase C, and l-type Ca(2+) channels in rats. J Neurosci Res. 2008, 86:471–479.

78. Sadegh M, Mirnajafi-Zadeh J, Javan M, Fathollahi Y, Mohammad-Zadeh M, Jahanshahi A, Nourbakhsh S M. The role of galanin receptors in anticonvulsant effects of low frequency stimulation in perforant path kindled rats. Neuroscience. 2007 Dec 5;150(2):396-403. Epub 2007 Oct 9.

79. Fereidoni M, Javan M, Semnanian S, Ahmadiani A.Chronic forced swim stress inhibits ultra-low dose morphine-induced hyperalgesia in rats.Behav Pharmacol. 2007,18, 667-72.

80. Esmaeili-Mahani S, Fereidoni M, Javan M, Maghsoudi N, Motamedi F, Ahmadiani A. Nifedipine suppresses morphine-induced thermal hyperalgesia: Evidence for the role of corticosterone. Eur J Pharmacol. 2007 Jul 12;567(1-2):95-101. Epub 2007 Mar 30.

81. Jamali A, Mahdavi M, Shahabi S, Hassan Z M, Sabahi F, Javan M, Jazayeri-Farsani M, Parsania M, Bamdad T. Naloxone, an opioid receptor antagonist, enhances induction of protective immunity against HSV-1 infection in BALB/c mice. Microb Pathog. 2007 Nov-Dec;43(5-6):217-23. Epub 2007 Jul 31.

82. Mohammad-Zadeh M, Mirnajafi-Zadeh J, Fathollahi Y, Javan M, Ghorbani P, Sadegh M, Noorbakhsh S M. Effect of low frequency stimulation of perforant path on kindling rate and synaptic transmission in the dentate gyrus during kindling acquisition in rats. Epilepsy Res. 2007 Jul;75(2-3):154-61. Epub 2007 Jun 18

83. Ghorbi J, Javan M, Sheibani V, Satarian L, Zarebkohan A. Possible role for integrins in development of tolerance to analgesic effect of morphine in rats. Physiology and Pharmacology. 2007, 11(2), 115-122.

84. Mohammad-Zadeh M, Mirnajafi-Zadeh J, Fathollahi Y, Javan M, Ghorbani P. Effect of low frequency stimulation of perforant path on kindling acquisition and synaptic transmission in the dentate gyrus in rats. Physiology and Pharmacology, 2007. 11 (2), 137-145.

85. Shamsizadeh A, Sheibani V, Fathollahi Y, Javan M, Mirnajafi-Zadeh J, Afarinesh M R. Neuronal response properties of somatosensory cortex (layer IV) are modulated following experience dependent plasticity in c-fiber depleted rats. Physiology and Pharmacology. 2007, 11(2), 91-98.

86. Javan M, Kazemi B, Ahmadiani A, Motamedi F. Dexamethasone Mimics The Inhibitory Effect of Chronic Pain on The Development of Tolerance to Morphine Analgesia and Compensates for Morphine Induced Changes in G Proteins Gene Expression. Brain Res. 2006 Aug 9;1104(1):73-9. Epub 2006 Jul 7.

87. Shahabi S, Hashemi M, Hassan Z M, Javan M, Bathaie S Z, Toraihi T, Zakeri Z, Ilkhanizadeh B, Hosseini-Jazani N. The Effect of Post-Burn Local Hyperthermia on The Reducing Burn Injury: The Possible Role of Opioids, Int. Journal of Hyperthermia. 2006, 22: 421–431.

88. Satarian L, Javan M, Fathollahi Y. Intrathecal administration of epinephrine inhibits and reverses analgesic tolerance to morphine in rats. Physiology and Pharmacology. 2006, 10: 57-62.

89. Amini H, Javan M, Ahmadiani A. Development and validation of a sensitive assay of valproic acid in human plasma by high-performance liquid chromatography without prior derivatization. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan 18;830(2):368-71. Epub 2005 Dec 1.

90. Movahedi S, Javan M, Ahmadiani A. Study on the possible similar mechanism of ultra low dose-induced hyperalgesia and development of tolerance to analgesia in male rats: an study based on the role of Gs signaling pathway. Physiology and Pharmacology. 10, 2006, 107-114.

91. Fereidoni M, Javan M, Semnanian S, Ahmadiani A. Hypothalamus Pituitary Adrenal axis and stimulatory G proteins signaling role in nociceptive changes induced by forced swim stress Physiology and Pharmacology. 2007, 291-302.

92. Farazifard R, Safarpour F, Sheibani V, Javan M. Eye-wiping test: a sensitive animal model for acute trigeminal pain studies. Brain Res Brain Res Protoc. 2005 Dec;16(1-3):44-9. Epub 2005 Nov 22.

93. Javan M, Ahmadiani A, Motamedi F, Kazemi B. Changes in G Proteins Genes Expression in Rat Lumbar Spinal Cord Support the Inhibitory Effect of Chronic Pain on the Development of Tolerance to Morphine Analgesia. Neurosci Res. 2005 Nov;53(3):250-6. Epub 2005 Aug 1.

94. Davoodi F G, Javan M, Ahmadiani A. The effect of swim stress on morphine tolerance development and the possible role of nitric oxide in this process. Iranian Journal of Pharmaceutical Research (IJPR). 2005.

95. Mahani S E, Motamedi F, Javan M, Ahmadiani A. Involvement of hypothalamic pituitary adrenal axis on the effects of nifedipine in the development of morphine tolerance in rats. Pharmacol Biochem Behav. 2005 May;81(1):152-7. Epub 2005 Apr 21.

96. Khaksarian M, Javan M, Sonboli A, Motamedi F. The Effects of Peripheral and Central Administration of Hypericumperforatum L. on Chronic and Acute Pain in Male Rats. Pak J Biol Sci, 8 (7), 2005, 949-953.

97. Ahmadiani A, Javan M, Semnanian S, Barat E, Kamalinejad M. Anti-inflammatory and antipyretic effects of Trigonella foenum-graecum leaves extract. J Ethnopharmacol. 2001 May;75(2-3):283-6.

98. Ahmadiani A, Hosseiny J, Semnanian S, Javan M, Saeedi F, Kamalinejad M, Sarami S. Antinociceptive and anti-inflammatory effects of Elaeagnus angustifolia fruit extract. J Ethnopharmacol. 2000 Sep;72(1-2):287-92.

99. Feriedoni M, Ahmadiani A, Semnanian S, Javan M. An accurate and simple method for measurement of paw edema. J Pharmacol Toxicol Methods. 2000 Jan-Feb;43(1):11-4.

100.         Javan M, Ahmadiani A, Semnanian S, Kamalinejad M. Anti-nociceptive effects of Trigonella foenum-graecum leaves extract. J Ethnopharmacol. 1997 Oct;58(2):125-9.

101.Khaksarian M., Javan M, Sonboli A., Motamedi F. Inhibition of acute and chronic pain in male rats by aqueous extract of Hypericum perforatum L. Yafte, 2004, 5, 11-17.

102.Javan M, Ahmadiani A, Motamedi F, Kazemi B. The Role of Gai/o and Gb Protein Gene Expression In Chronic Morphine Induced Tolerance to Analgesia in Rat Lumbar Spinal Cord. The Cell (Yakhteh), 2003, 5 (17) 45-52.

103.Javan M, Masoudnia F, Motamedi F, Ahmadiani A. Possible relevance of tolerance to analgesic effect of morphine due to chronic inflammatory pain and the role of lumbar spinal cord in this interaction. Physiology and Pharmacology. 7(1), 2003.

104.Ahmadiani A, Javan M, Motamedi F, Kazemi B. Effect of chronic inflammatory pain on gene expression level of a subunit of inhibitory G proteins (Gai) in lumbar spinal cord of rat. Physiology and Pharmacology, Proceeding of 16th Iranian Congress of Physiology and Pharmacology. 2003, Tehran, Iran.

105.Ahmadiani A, Jesmani T, Javan M. The role of ATP-dependent K+ channel in antinociception, tolerance and morphine dependence. Physiology and Pharmacology. 3(2), 2000.

106.Parvizpur A R, Ahmadiani A, Javan M, Kamalinejad M. Study on the site of antinociceptive effect of Trigonella foenum-graecum (TFG) leaves extract in phasic and tonic models of pain. Physiology and Pharmacology, 3(2). 2000.

107.Farzaneh P, Baharvand H, Javan M, Kazemi S. Text book of “Biology” (2nd year of high school), Iranian Ministry of Education and Training Press. 2000.

Supervising Post-graduate thesis