Seyed Alireza Mesbah Namin
Associate Professor
Speciality: Clinical Biochemistry
  • BS/BA: Chemistry
  • MS: Clinical Biochemistry
  • PhD: Clinical Biochemistry
  • Phone: 82883570
  • Fax: 82883818
  • Email: mesbahna@modares.ac.ir
    • Address: School of Medical Sciences, Tarbiat Modares University
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Seyed Alireza Mesbah-Namin

Ph.D, Associate professor

 Dept. of Clinical Biochemistry, Faculty of Medical Sciences

P.O. Box:  14115- 331, Postal code: 14117-13116

Tarbiat Modares University (TMU), Tehran, Iran.

Tel:  +9821-82883570/ +9821-82884565

Fax:  +9821-82883818 / +9821-82884555

E-mails:  mesbahna@modares.ac.ir / mesbahnamin@yahoo.com

 

 

Date:  28th May 2016

 

I.             BIOGRAPHICAL INFORMATION

 

Date of birth: 8 September 1957

Citizenship: Iranian

Place of birth: Tehran, Iran

Marital status: Married

Address at work: Chamran and Jalale Ale-Ahmad cross road- Tarbiat Modares University, Tehran, Iran

Phone at lab: +9821-82884565

Phone at work/office: +9821-82883570

 

II.             EDUCATIONAL RECORDS:                                                                           

 

Ph.D in Clinical Biochemistry, from TMU, Tehran, Iran, 2001

Title of Thesis:  Identification of molecular mutations of Glucose-6-Phosphate Dehydrogenase (G6PD) gene in deficient subjects in Mazandaran province of Iran. Supervisors: Mohammed Noori-Daloii (Iran) and Tom Vulliamy (UK)

M.Sc. in Clinical Biochemistry, from TMU, Tehran, Iran, 1989. Title of Thesis:  Isolation of Nerve Growth Factor (NGF) by HPLC from mice submaxillary glands. Supervisor: Taki Tiraihi (Iran)

B.Sc. in Chemistry, from Teacher Training University, Tehran, Iran, 1984

  

III.         SABBATICAL LEAVE  

On sabbatical leave, Dept. of Molecular Medicine and Max-Plank Research Group for stem cell aging , Ulm University, Ulm , Germany , 21st July 2010 – 31st Jan 2011. 

 

 ( Supported by Ministry of Science, Research and Technology of Iran and TMU, Tehran, Iran ). 

 

 IV.           EMPLOYMENT HISTORY:

 

Associate Professor: May 2008 - present

Assistant Professor: March 2002- May 2008

Researcher and Lecturer: March 1996 - March 2002

 

V.            ACADEMIC EXPERIENCES:                                                                     

 

Supervisor of research works, 2001-present

Supervising M.Sc. students who are working on multiple-subjects in TMU and Azad University, Tehran, Iran

Instructor, Teaching and Research Assistant, 1989-2001 
Tarbiat Modarres University (TMU), Zahedan and Tehran University

Courses: Advance techniques in Biochemistry, Some aspects of clinical Biochemistry and Molecular Biology

 Lecturer for the Biosafety training courses related to the chemical and biological hazards in research laboratories of the faculties of Medical and biological sciences of Tarbiat Modares University, Tehran, Iran for the period time from 2002 till now ( 2015)

 

  

VI.               MEMBERSHIP OF SCIENTIFIC SOCIETIES:

 

Member of Biochemical Society of Islamic Republic of Iran

Member of Iranian genetic society, Tehran, Iran

Member of Iranian society for Biotechnology, Tehran, Iran

Member of Iranian society for Trace Element Research (ISTER)

Member of Biosafety Committee of Tarbiat Modares University, Tehran, Iran

Member of Biosafety Committee of the Ministry of Science, Research and Technology of Islamic Republic of Iran

 

VII.             REFEREE FOR SCIENTIFIC JOURNAL:

 

1- British J. of Hematology

2- European J. of Hematology

3- Iranian J. of Biotechnology

4- Iranian Biomedical J.

5- Yakhteh (the cell) Medical J.

6- Modares J. of Medical Sciences: Pathobiology

7- Avicenna Journal of Medical Biotechnology

 

VIII.            RESEARCH INTERESTS:

 

My interests could be divided into the 4 categories which are as follows:

1- Mutation research, Genotyping and Gene silencing

 2- Pathogenesis of Multiple sclerosis- Genetics and epigenetics

 3- DNA Damage evaluation

 4- Telomere and telomerase in aging of Stem cells and cancerous cell lines

 

 

IX.           PUBLICATIONS:                                                                           

 

    A. Full papers (In English):

1994

1-  Totonchi A., Rassaee M. J., Allameh A.A., Assadikaram G. R. and Mesbah-Namin S. A. Development of a rapid and sensitive radio immunoassay for measurement of Aflatoxin B1 in biological samples. Medical Journal of the Islamic Republic of Iran, 8(1), 35-41, 1994.

 

2000

2- Mesbah-Namin S. A., Sanati M. H., Mowjoodi A. and M. R. Noori-Daloii. Spread of the Glucose-6-phosphate dehydrogenates variant (G6PD-Mediterranean) in one of the coastal provinces of Caspian Sea in Iran. Medical Journal of Sciences, Islamic Republic of Iran. 11(4) 285-288, 2000.

 

2002

 3- Mesbah-Namin S. A., Sanati M. H., Mowjoodi A., Mason P. J., Vulliamy T. J. and M. R. Noori-Daloii. Three major glucose-6-phosphate dehydrogenase polymorphic variant identified in Mazandaran state of Iran. British Journal of Hematology, 117, 1-2, 2002. 

 

2003

4-  Clarke J.L., Vulliamy T.J., Roper D., Mesbah-Namin S.A., Wild B.J., Walker J.H., Will A.M., Bolton-Maggs P.H., Mason P.J. and D.M. Layton . Combined glucose-6-phosphate dehydrogenase and glucose phosphate isomerase deficiency can alter clinical outcome. Blood Cells, Molecules and Disease, 30,258-263, 2003

 

2004

5- Mohandesan E., Mowla S.J., Hojabri-Noori A., Yaghoobi M.M. and  Mesbah-Namin S. A. Extraction and analysis of ancient DNA from human remains of Masjede Kabood burial site.  Iranian J. of Biotechnology, 2 (4), 236-242, 2004

6- Ghoudarzi B. Gh., Lotfi A., Mesbah-Namin S. A., Zare Mirakabadi A.and Bagherian R. Isoelectric focusing and PCR-RFLP joined techniques for Alpha1- antitrypsin deficiency detection.  Archives of Razi Institute, 58, 39-49, 2004

7- Mesbah-Namin S. A., Nemati A and Taki Tiraihi. Evaluation of DNA damage in leukocytes of G6PD-deficient Iranian newborns (Mediterranean variant) using comet assay.  Mutation Research, 568, 179–185, 2004

 

2005

8- Lotfi A.S., Mesbah-Namin S. A, Goudarzi GH. B. and Zare Mirakabadi A. Determination of alpha1-  antitrypsin phenotypes and genotypes in Iranian patients. Iranian J. of Biotechnology, 3 (4), 249-254, 2005

 

2007

9- Mohammadian Yajloo M., Sahebghadam Lotfi A.S., Mesbah- Namin S.A., hasannia S., Biglarzadeh M and Ardalan A. Rapid α-1 antitrypsin M-variant genotyping by primer- induced restriction analysis. Diagnostic Molecular pathology, 16(1), 54-56, 2007

10- Noori-Daloii M.R., Hajebrahimi Z., Najafi L. Mesbah-Namin S.A. , Mowjoodi A., Mohammad Ganji S., Yekaninejad M.S., Sanati M.H. A comprehensive study on the major mutations in glucose-6-phosphate dehydrogenase-deficient polymorphic variants identified in the coastal provinces of Caspian Sea in the north of Iran.

Clinical Biochemistry, 40, 699–704, 2007

11- Hakhamaneshi M.S., Mesbah-Namin S.A., Houshmand M., Sahebghadam Lotfi A., Alteration in antioxidant capacity in patients with chronic obstractive pulmonary disease. Tanaffos, 6(4), 13-17, 2007

 

2008

12- Movaghar B, Taki Tiraihi, Mesbah-Namin S.A. Transdifferentiation of bone marrow stromal cells into schwann cell phenotype using progesterone as inducer. Brain Research, 1208, 17-24, 2008

 

2009

13- Naghdi M, Taki Tiraihi, Mesbah-Namin S.A. Arabkheradmand J.

 Transdifferentiation of bone marrow stromal cells into cholinergic neuronal phenotype: a potential source for cell therapy in spinal cord injury. Cytotherapy,  11, 137-152, 2009.

14- Naghdi M, Tiraihi T, Mesbah-Namin S.A., Arabkheradmand J. Induction of bone marrow stromal cells into cholinergic-like cells by nerve growth factor. Iranian Biomedical J. 13 (2):117-23. 2009

15-  Yavari K., Taghikhani M, Maragheh M.G., Mesbah-Namin S.A., Babaei M.H.  Knockdown of IGF-IR by RNAi inhibits SW480 colon cancer cells growth in vitro. Archives of Medical Research. 40(4): 235-40, 2009.

 

2010

16- Ghorbanian M.T., Tiraihi T, Mesbah-Namin S.A., Fathollahi Y. Selegiline is an efficient and potent inducer for bone marrow stromal cell differentiation into neuronal phenotype. Neurological Research . 32 (2):185-93. 2010

17- Yavari K, Taghikhani M, Maragheh M.G., Mesbah-Namin SA, Babaei MH, Arfaee AJ, Madani H, Mirzaei HR. SiRNA-mediated IGF-1R inhibition sensitizes human colon cancer SW480 cells to radiation. Acta Oncologica. 49(1):70-5. 2010

18-  Yavari K, Taghikhani M, Ghannadi Maragheh M, Mesbah-Namin SA, Babaei MH.  Downregulation of IGF-IR expression by RNAi inhibits proliferation and enhances chemosensitization of human colon cancer cells. International J. of Colorectal Disease . 25 (1) :9-16. 2010

19- Daneshpour MS, Zarkesh M, Hedayati M, Mesbah-Namin SA, Halalkhor S, Faam B, Azizi F. The G360T polymorphism in the APO AIV gene and its associatiom with combined HDL/LDL-chlestrol phenotype: Tehran Lipid and glucose study. International Journal of endocrinology and Metabolism 1: 32-38, 2010

  

2011

20 -Halalkhor S, Mesbah-Namin SA, Daneshpour MS, Hedayati M, Azizi F. Association of ATP-binding cassette transporter-A1 polymorphism with apolipoprotein AI level in Tehranian population. Journal of Genetics. 90(1):129-32 ,2011.

 

2012

21- Daneshpour MS, Faam B, Mansournia MA, Hedayati M, Halalkhor S, Mesbah-Namin SA, Shojaei S, Zarkesh M, Azizi F. Haplotype analysis of Apo AI-CIII-AIV gene cluster and lipids level: Tehran lipid and glucose study. Endocrine. 41(1):103-10, 2012.

22- Faezizadeh Z, Mesbah-Namin SA, Allameh A. The effect of silymarin on telomerase activity in the human leukemia cell line k562.Planta Med. 2012 Jun;78(9):899-902. Epub 2012 Apr 24.
 

23- Mohammad-Gharibani P, Tiraihi T, Mesbah-Namin SA, Arabkheradmand J, Kazemi H. Induction of bone marrow stromal cells into GABAergic neuronal phenotype using creatine as inducer. Restorative Neurology and Neuroscience , 2012 Jan 1;30(6):511-25. doi: 10.3233/RNN-2012-100155.

 

 2013

 

24- Gharib A, Faezizadeh Z, Mesbah-Namin SA. In vitro and in vivo antibacterial activities of cyanidinum chloride-loaded liposomes against a resistant strain of Pseudomonas aeruginosa. Planta Medica, 2013 Jan;79(1):15-9.
25- Zahednasab H, Balood M, Mesbah-Namin SA. Comment on "matrix metalloproteinase-7 and matrix metalloproteinase-9 in pediatric multiple sclerosis". Pediatric Neurology, 2013 Mar;48(3):255.
26- Zahednasab H, Mesbah-Namin SA, Sahraian MA, Balood M, Doosti R. Relationship between NF-κB1 -94 ins/del ATTG polymorphism and susceptibility of multiple sclerosis in Iranian MS patients. Neuroscience Letters, 545: 46-49, 2013.
 27- Naghdi M, Tiraihi T, Mesbah-Namin SA, Arabkharadmand J, Kazemi H, Taheri T. Improvement of Contused Spinal Cord in Rats by Cholinergic-like Neuron Therapy. Iran Red Crescent Medical Journal, 2013 Feb;15(2):127-35.
28- Siroos B, Balood M, Zahednasab H, Mesbah-Namin SA, Pourgholy F, Harirchian MH. Secretory Phospholipase A2 activity in serum and cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis. J Neuroimmunol. 2013 Sep 15;262(1-2):125-7.
 
 
2014 
 

 

29- Balood M, Mesbah-Namin SA, Sanati MH, Zahednasab H, Sahraian MA, Ataei M. Inhibitor IκBα promoter functional polymorphisms in patients with multiple sclerosis. Mol Biol Rep. 2014 Feb;41(2):613-6.

30- Noori-Zadeh A, Mesbah-Namin SA, Tiraihi T, Rajabibazl M, Taheri T. Non-viral human proGDNF gene delivery to rat bone marrow stromal cells under ex vivo conditions. J Neurol Sci. 2014 Apr 15;339(1-2):81-6.

31- Balood M, Zahednasab H, Siroos B, Mesbah-Namin SA, Torbati S, Harirchian MH. Elevated serum levels of lysophosphatidic acid in patients with multiple sclerosis. Hum Immunol. 2014 May;75(5):411-3.

32- Gharib A, Faezizadeh Z, Mesbah-Namin SA, Saravani R. Preparation, characterization and in vitro efficacy of magnetic nanoliposomes containing the artemisinin and transferrin. Daru. 2014 May 28;22:44. doi: 10.1186/2008-2231-22-44.

33- Zahednasab H, Balood M, Harirchian MH, Mesbah-Namin SA, Rahimian N, Siroos B. Increased autotaxin activity in multiple sclerosis. J Neuroimmunol. 2014 Aug 15;273(1-2):120-3. doi: 10.1016/j.jneuroim.2014.06.006.

34- Mesbah-Namin SA, Gunes C. Analysis of expression levels of E2F transcription factors in lineage negative hematopoietic stem cells of young and old mice. Molecular and Biochemical diagnosis. 2014 spring; 1 (1), 35-40

35- Darvishi M, Tiraihi T, Mesbah-Namin SA, Delshad A, Taheri T.Decreased GFAP Expression and Improved Functional Recovery in Contused Spinal Cord of Rats Following Valproic Acid Therapy. Neurochem Res. 2014 Dec;39(12):2319-33. doi: 10.1007/s11064-014-1429-5

 
2015
36- Zahednasab H, Mesbah-Namin SA, Balood M. Coenzyme Q10 supplementation and multiple sclerosis.  Nutr Neurosci. 2015 May;18(4):192. doi: 10.1179/1476830514Y.0000000126
37- Deyhim MR, Mesbah-Namin SA, Yari F, Taghikhani M, Amirizadeh N. L-carnitine effectively improves the metabolism and quality of platelet concentrates during storage. Ann Hematol. 2015 Apr;94(4):671-80. doi: 10.1007/s00277-014-2243-5. Epub 2014 Nov 18.
38- Nazemi L, Skoog I, Karlsson I, Hosseini S, Mohammadi MR, Hosseini M, Hosseinzade MJ, Mesbah-Namin SA, Baikpour M. Malnutrition, Prevalence and Relation to Some Risk Factors among Elderly Residents of Nursing Homes in Tehran, Iran. Iran J Public Health. 2015 Feb;44(2):218-27.
39-Rezaei M, Dadgar Z, Noori-Zadeh A, Mesbah-Namin SA, Pakzad I, Davodian E. Evaluation of the antibacterial activity of the Althaea officinalis L. leaf extract and its wound healing potency in the rat model of excision wound creation. Avicenna J Phytomed. 2015 Mar-Apr;5(2):105-12.

40- Gharib A, Faezizadeh Z, Mesbah-Namin SA, Saravani R. Experimental treatment of breast cancer-bearing BALB/c mice by artemisinin and transferrin-loaded magnetic nanoliposomes. Pharmacogn Mag. 2015 May;11(Suppl 1):S117-22. doi: 10.4103/0973-1296.157710.

 

41- Mokari-Zadeh N, Mesbah-Namin SA. Evaluation of an Improved Non-invasive Fetal Sex Determination in Haemophilia A Patients. J Clin Diagn Res. 2015 Jul;9(7):GC01-4. doi: 10.7860/JCDR/2015/12556.6175. Epub 2015 Jul 1.

 

 

2016
 
42- Noori-Zadeh A, Mesbah-Namin SA, Bistoon-Beigloo S, Bakhtiyari S, Abbaszadeh HA, Darabi S, Rajabibazl M, Abdanipour A. Regulatory T cell number in multiple sclerosis patients: A meta-analysis. Mult Scler Relat Disord. 2016 Jan;5:73-6. doi: 10.1016/j.msard.2015.11.004.
 
43- Darvishi M, Tiraihi T, Mesbah-Namin SA, Delshad A, Taheri T. Motor Neuron Transdifferentiation of Neural Stem Cell from Adipose-Derived Stem Cell Characterized by Differential Gene Expression. Cell Mol Neurobiol. 2016 Apr 23. [Epub ahead of print]

 

 

X.  REFEREES

 

1- Allameh A., Ph.D., Professor

Dept. of Biochemistry, School of Medical Sciences, TMU,

P.O.Box: 14155- 331, Tehran, IRAN

Tel: +98 21 82883585

Fax: +98 21 8006544

Email: allameha@modares.ac.ir

  

 

 

 

 

 

2- S. Lotfi A., Ph.D., Professor

Dept. of Biochemistry, School of Medical Sciences, TMU,

P.O.Box: 14155- 331, Tehran, IRAN

Tel: +98 21 82883594

Fax: +98 21 82883818

Email: lotfi-ab@modares.ac.ir    

 

 

 

C.             Full papers (in Persian): 

 

2000

1- Sammak H., Haji Fathali A. and Mesbah-Namin S. A. Investigation of lipids and lipoprotein cholesterol levels in patients with Acute Lymphoblastic Leukemia. Pejouhesh, Journal of the faculty of Medicine,  Shahid Beheshti University, 24 (1), 7-14, 2000. 

 

2001

2- Lotfi A.  Hakhamaneshi M. S.,  Yadegari M. H. and Mesbah-Namin S. A.  Optimization of glucose oxidase production by Aspergillus Niger. Pajouhesh-va-Sazandegi in animal sciences. 51, (6-7) 2001 

 

2002

3- Lotfi A.  Hakhamaneshi M. S.,  Yadegari M. H. and Mesbah-Namin S. A. Production, purification and determination of some physiochemical properties of D-glucose oxidase from Aspergillus Niger.  Modarres, Journal of Medical Sciences. TMU, 5 (1), 65-74, 2002

 

2004

4-Soleimani E., Mesbah-Namin S.A., Asilian H., Soleimanian A. Evaluation of occupational exposure to nickel compound in abig electroplating workshop in west of Tehran.  Daneshvar Medicine, Scientific –Research J. of Shahid University, 53, 13-20, 2004

 

2005

5- Mesbah-Namin S.A., Kavianpour A., Mowla S.J., Tiraihi T. Sex determination of human fetus using nested-PCR. Yakhteh Medical J., 6(24), 202- 205 , 2005

6- Lotfi A.S., Mohammadian Yajloo S.A., Mesbah-Namin S.A., Hasannia S., Beiglarzadeh Goodarzi B. The frequency of the alpha-1-antitrypsin M1, M2, M3, S and Z variants in Iranian population.  J. of Rafsanjan University of Medical Sciences and Health Services, 4(1), 25-39, 2005

 

2006

7- Rahmdani F,. Mesbah-Namin S.A., Tarihi T. Non-invasive fetal RHD genotyping by hemi-nested PCR of maternal serum in RHD-negative pregnancies. Blood, The scientific Journal of Iranian Blood Transfusion Organization-Research Center,3 (2), 93-100, 2006

8- Zamani-Taghizadeh S., Zavaran Hoseini A., Mesbah-Namin S.A. The role of 6-Aminonicotinamide in the resistance of peritoneal macrophages against Leishmania majr infection in BALB/C mouse.Tehran University Medical L. 64(9), 10-18, 2006

 

2007

9-Ghorbanian M.T., Tiraihi T., Mesbah-Namin S.A., Fathollahi Y. Induction effect of deprenyl on transdifferention of BMSCs into neuron and glial-like cells in vitro. Yakhteh Medical J., 9(1), 15-22, 2007

10- Najjar Sadeghi R., Mesbah-Namin S.A., Rastgar-Jazi F. Methylation status of p15 gene in esophageal squamous cell carcinoma using methylation-specific PCR. Yakhteh Medical J., 9(1),39-44,, 2007

11- Zamani Taghizadeh Rabe Sh, Zavaran Hosseini A, Mesbah Namin SA.  The Role of Dehydroepiandrosterone on Leishmania Major Replication in ‎BALB/c Peritoneal Macrophages. Kowsar Medical J., 12 (3), 219-228, 2007

12- Hakhamaneshi M.S., Mesbah-Namin S.A., Houshmand M., Sahebghadam Lotfi A., Assessment of cytochrome C oxidase activity in white blood cells of patients with chronic obstractive pulmonary disease. Journal of Babol university of medical sciences, 10 (1), 14-19, 2007.

 

2008

13-Ghorbanian M.T., Tiraihi T., Mesbah-Namin S.A., Fathollahi Y. Immunohistochemical study on the inductive effects of Deprenyl on differentiation of BMSCs into dopaminergic neurons. Daneshvar Medicine, Scientific,Research J. of Shahid University,14(73), 27-36, 2008

14- Movaghar B, Taki Tiraihi, Mesbah-Namin S.A. Comprison between the effect of forskolin as an inducer with ther effect of beta mercaptoethanol and retinoeic acid in transdifferentiation of BMSCs into schwann cells. Daneshvar Medicine, Scientific, Research J. of Shahid University,15(75), 79-86, 2008

15- Skandari A., Yadegari M. H. and Mesbah-Namin S. A. Identification of important pathogenic yeast candida species in acute candidiasis using PCR.  Kowsar Medical J., 13 (2), 154-124, 2008

 

2012