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Midazolam is considered as one of the best first-line drugs in managing status epilepticus in children who require emergency drug treatment. Due to poor water solubility, oral bioavailability of midazolam is relatively low. To improve its dissolution and absorption, midazolam nano-suspensions were formulated with different stabilizers using the ultrasonic technique. A combination of Tween 80 and Poloxamer (TP) was considered as one stabilizer and 3-methyl chitosan (TMC) as another stabilizer. The ratio of the stabilizers was selected as an independent variable, and their effects on the particle size and the zeta potential were evaluated by the simplex lattice mixture method. The freeze-dried optimized midazolam nano-suspension powder was ch
The encapsulation of ascorbic acid within chitosan nanoparticles (CHNs), embedded in a fibrous structure of a dexamethasone (Dex)-loaded PCL scaffold, provides a new plan for osteogenic differentiation of mesenchymal stem cells. This electrospun PCL fibrous scaffold can release Dex, as bone differentiation initiator, and ascorbic acid, as bone differentiation enhancer, in an approximately sustained release pattern for about 2 weeks. Ascorbic acid-loaded CHNs were prepared by electrospraying a mixture of chitosan and ascorbic acid, and Dex-containing PCL fibers were prepared by electrospinning a mixture of PCL and Dex. The final PCL/chitosan bilayer scaffolds were obtained by the sequential employment of electrospinning and electrospraying m
Genistein (GEN), a soybean isoflavone, is structurally and functionally similar to endogenous estrogen; therefore, it has potential to enhance estradiol properties. This study was designed to evaluate the effects of GEN on the reproductive performance and bone status of laying hens. Eighty 40-wk-old (the late stage of egg production cycle) Hyline W-36 with initial body weight of 1,230 ? 15.8 g (Mean?S.E.M) and similar egg production, egg weight, were randomly assigned to two groups with 10 replicates and 4 birds in each replicate (40 laying hens per group). Laying hens fed diets with 0 (control) and 20 mg/kg GEN (white powder, Sichuan Guanghan co. Ltd., purity of 98.5%) for 6 weeks (41 to 46). At the end of experiment 20 hens (one hens from
see more details process, soybeans were affected for 20-30 seconds at 150-160 C in the extruder by heat and pressure and finally were dried and cooled. In the process of roasting, the soybean for 15 minutes at temperature of 145 C was heated and for 45 minutes holding tank for heat storage remained. Seeds seeds Subject Category: Anatomical and Morphological Structures
The main goal of this research was to compare the in vitro release rates of nano-and microcapsules of Silybum marianum extract (SME) in animal simulated gastric and intestinal medium conditions. The extract was encapsulated within sodium alginate carriers using emulsification/internal gelation method. Particle size, zeta potential, polydispersity index (PDI) and morphology of nanocapsules were analysed via dynamic light scattering (DLS) and transmission electron microscopy (TEM). In addition, the effect of ultrasonication on nanocapsule properties and the release profiles of SME-loaded nano/microcapsules were evaluated. Results showed that ultrasonication reduced the size of capsules from 657.5 nm to 169.1 nm which resulted in uniform parti
This study was carried out to investigate the chemical composition, antioxidant properties antioxidant properties Subject Category: Properties
The objective of this study was to evaluate antioxidant and hepatoprotective activities of nanoencapsulated silymarin (NES) against carbon tetrachloride-induced oxidative stress in broiler chickens. An in vitro study was conducted using a 20 kHz ultrasound with 62.5% amplitude to produce NES, stabilized by alginate for controlled release of its bioactive compounds in simulated gastrointestinal tract of broiler chickens. Results showed that sonication reduced the size of particles from 657.5 to 169.1 nm and polydispersity index from 0.60 to 0.31.Simulated gastrointestinal digestion in vitro indicated that NES was more resistant to gastric fluid compared to intestinal fluid. An animal model study was designed to investigate the antioxidan
The main goal of this research was to compare the in vitro release rates of nano-and microcapsules of Silybum marianum extract (SME) in animal simulated gastric and intestinal medium conditions. The extract was encapsulated within sodium alginate carriers using emulsification/internal gelation method. Particle size, zeta potential, polydispersity index (PDI) and morphology of nanocapsules were analysed via dynamic light scattering (DLS) and transmission electron microscopy (TEM). In addition, the effect of ultrasonication on nanocapsule properties and the release profiles of SME-loaded nano/microcapsules were evaluated. Results showed that ultrasonication reduced the size of capsules from 657.5 nm to 169.1 nm which resulted in uniform parti
Introduction: In feeding of dairy cows, well balanced diet and the proper amount of dietary fiber and particle sizeare necessary. Also, management of feed and feed intake is very important. On the other hand, increasing the intake of dry matter in lactating cows during early lactation is vital for improving milk production, animal health, and physical condition (Grant and Albright, 1995). One of the factors affecting animal health, is the physical properties of the feed, which has a strong relationship with the health of the digestive tract and animal feeding behaviors. Many researches have shown that cows tend to consume fine-grained components of their diet and makes selective consumption against larger components of the diet, while coars
Nanotechnology based drug delivery systems have been explored extensively in cancer therapy over the past decades. Among the vast number of different materials used in nanocarrier systems, natural biopolymers are most frequently used in the encapsulation of chemotherapeutic drugs. However, the low solubility of these agents within biological fluid has decreased their efficacy for inhibiting the growth of cancer cells. Herein, we have developed a new biodegradable and biocompatible drug delivery system based on Dextran. Specifically, we have prepared lipid-conjugated dextran through esterification process using stearic acid (SA) and cholesterol (Chol). In vitro toxicity studies of unloaded and rapamycin loaded nanocarriers with U87 MG cell l
Gallic acid (GA) is a natural and non-enzymatic antioxidant with known anticancer property. In the present work, two types of mesoporous silica nanoparticles (MSNs) were evaluated as a nano carrier for sustained release of GA. For this purpose, amine-functionalized (AP-MSNs) and chitosan coated (CS-MSNs) MSNs were synthesized, loaded by GA and then characterized by SEM, XRD, N2 adsorption isotherms and zeta-potential analysis. Optimum conditions for the loading of GA into the modified MSNs were obtained, and then in vitro GA release in simulated gastric fluid (SGF, pHs 1.4) was investigated. Cytotoxicity and cellular uptake of the modified MSNs were also investigated using MCF-7 cells. The encapsulation efficiency and loading capacity wer
This work aimed to using optimization study to formulate a patient-friendly captopril fast-dissolving oral film with satisfactory disintegration time. Films were made with pullulan and hydroxypropyl methyl cellulose (HPMC) by using the solvent-casting method. Cellulose nanofiber (CNF) was used as a compatibilizer and glycerine was used as a plasticizer. In order to find an optimum formulation, a response surface methodology and a central composite design were employed. The concentration percentages of pullulan and glycerine were considered to be the design factors. Disintegration time, tensile strength, percent elongation at break, and folding endurance were considered to be the responses. The results showed that CNF improved t
A method for producing an antibiotic-loaded transdermal patch including preparing a polymeric adhesive solution by dissolving a polymeric mixture in a solvent, preparing a plurality of antibiotic-loaded solid lipid nanoparticles (SLNs), forming a patch formulation by mixing the plurality of antibiotic-loaded SLNs and the polymeric adhesive solution, and forming a layer of the patch formulation on a substrate.
Rivastigmine hydrogen tartrate (RHT) is a pseudo-irreversible inhibitor of cholinesterase and is used for the treatment of Alzheimer's. However, RHT delivery to the brain is limited by the blood–brain barrier (BBB). The purpose of this study was to improve the brain-targeting delivery of RHT by producing and optimizing rivastigmine hydrogen tartrate-loaded tocopherol succinate-based solid lipid nanoparticles (RHT-SLNs). RHT-SLNs were prepared using the microemulsion technique. The impact of significant variables, such as surfactant concentration and drug/lipid ratio, on the size of RHT-SLNs and their drug loading and encapsulation efficiency was analysed using a five-level central composite design (CCD). The minimum size of particles and
Objectives: The main objective of this novel study was to develop midazolam hydrochloride fast dissolving oral films (FDFs) using solvent casting method and to evaluate the characteristics of the optimum formulation through in vitro and in vivo analysis. The FDFs are new favorable solid dosage forms that deliver drugs rapidly to the blood circulation system and have great advantages in the emergent control of severe neuropathic attacks in children. Methods: Midazolam nanosuspensions were prepared using the ultrasonic method and then incorporated in the hydroxypropyl methyl cellulose (HPMC)/pullulan polymeric matrix with other excipients like glycerol and cellulose nanofiber as a softener and a compatibilizer, respectively. The prepared film
see more details of feed which may be used to optimize fermentation and digestion (Dann et al., 1999). Cereal processing can make optimal use of them, reduce nutrient losses, and also make livestock livestock Subject Category: Organism Groupssee more details more balanced, which is very important in animal nutrition management. The aim of this study was to determine the effect of pelleting pelleting Subject Category: Techniques, Methodologies and Equipment