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The COVID-19 pandemic has caused unprecedent negative impacts on our society, however, evidences show a reduction of anthropogenic pressures on the environment. Due to the high importance of environmental conditions on human life quality, it is crucial to model the impact of COVID-19 lockdown on environmental conditions. Consequently, the objective of this study was to model the impact of COVID-19 lockdown on the urban surface ecological status (USES). To this end, the Landsat-8 images of Milan for three pre-lockdown dates (Feb 13, 2018 (MD1), April 18, 2018 (MD2) and Feb 3, 2020 (MD3)) and one date over the lockdown (April 14, 2020 (MD4)), and Wuhan for three pre-lockdown dates (Dec 17, 2017 (WD1), March 23, 2018 (WD2) and Dec 7, 2019 (WD3