Department of NanoBiotechnology (2014 - Present)
Nano technology
Institute for Nanoscience and Nanotechnology, Sharif Uneverity of Technology, Tehran, Iran
Materials Engineering
Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
Materials Engineering
Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
Research field: Regenerative Nanomedicine
Expert:
Phone: 021-82884756
Address: Faculty of Biological Science, 1st Floor, #5010
Dr. Elnaz Tamjid is Associate Professor in Department of Nanobiotechnology at Tarbiat Modares University, Iran. She has been the Head of Nanobiotechnology Department (2019-2022), and awarded ?Distinguished Researcher? (2021-2022).
She was a Postdoctoral Fellow in the Institute of Biomaterials and Biomedical Engineering (IBBME) at the University of Toronto, Canada. She received her Ph.D. in Nanotechnology from the Institute for Nanoscience and Nanotechnology at Sharif University of Technology, Iran. She has also received several prestigious scholarships and awards such as Erasmus Mobility Grant, Nanoprototype Start-up Grant, Incubator Postdoctoral Fellowship, Nanotechnology Research Grant, Exceptional Talents Award, and 5th Khwarizmi Student Award.
Dr. Tamjid has been the ?Coordinator of International Affairs? in Faculty of Biological Sciences (2018-2022) and involved in variety of international research collaborations with Max-Planck Institute, Farunhofer Institute, University of Toronto, and University of Tampere. She is the Editorial Board Member of Scientific Reports (Nature Publishers), and has published 40 papers in peer-reviewed journals as well as 30 presentations in several international and national conferences in different countries. She has also been able to register a number of patents in national level.
Her research focus is to design, develop, optimize, and characterize novel functional biomaterials through Advanced Manufacturing processes with particular emphasize on 3D Bioprinting for Tissue Engineering and Regenerative Medicine Applications.
Wound healing is a complex process based on the coordinated signaling molecules and dynamic interactions between the engineered scaffold and newly formed tissue. So far, most of the engineered scaffolds used for the healing of full-thickness skin wounds do not mimic the natural extracellular matrix (ECM) complexity and therefore are not able to provide an appropriate niche for endogenous tissue regeneration [1]. To address this gap and to accelerate the wound healing process, we present biomimetic bilayer scaffolds compositing of gelatin nanofibers (GFS) and photocrosslinkable composite hydrogels loaded with epidermal growth factors (EGF). The nanofibers operate as the dermis layer, and EGF-loaded composite hydrogels acted as the epidermis
Magnesium-based implants (MBIs) have recently attracted great attention in bone regeneration due to elastic modulus similar to bone. Nevertheless, the degradation rate and hydrogen release of MBIs in the body have to be tackled for practical applications. In the present study, we present a metal–organic framework (MOF) nanoplates to reduce the degradation rate of AZ91 magnesium alloy. Zeolitic imidazolate frameworks (ZIF-8) with a specific surface area of 1789 m 2 g− 1 were prepared by solvothermal methods, and after dispersion in a chitosan solution (10% w/w), the suspension was electrospun on the surface of AZ91 alloy. Studying the degradation rate in simulated body fluid (SBF) by electrochemical analysis including potentiodynamic pol
Titanium alloys are commonly used in orthopedic devices due to their good corrosion resistance, high specific strength and excellent biological response. The direct contact between the implant surface and the host tissue results in notable effect of surface properties such as surface topography on the biological responses. The aim of this study is to investigate the effect of frequency of pulsed Nd-YAG laser on Ti6Al4V alloy surface topography and its influence on the improvement of biocompatibility while other laser parameters kept constant. The range of applied frequency values were selected from 1 to 20?Hz. The range of surface roughness was found between 452?nm and 3.37?μm. The untreated sample and also samples with the highest and the
Coaxial electrospinning with the ability to use simultaneously two separate solvents provides a promising strategy for drug delivery. Nevertheless, controlled release of hydrophilic and sensitive therapeutics from slow biodegradable polymers is still challenging. To address this gap, we fabricated core-sheath fibers for dual delivery of lysozyme, as a model protein, and phenytoin sodium as a small therapeutic molecule. The sheath was processed by a gelatin solution while the core fibers were fabricated from an aqueous gelatin/PVA solution. Microstructural studies by transmission and scanning electron microscopy reveal the formation of homogeneous core-sheath nanofibers with an outer and inner diameter of 180???48?nm and 106???30?nm, respect
Magnesium alloys have recently attracted significant attention for the fabrication of biodegradable orthopedic implants and cardiovascular stents. Nevertheless, the high degradation rate of magnesium alloys under physiological conditions is still challenging. We present a surface modification strategy to tailor the degradation rate and in vitro cell behavior of AZ91 alloy through electrospinning of continuous poly (ε-caprolactone) fibers containing bioactive glass nanoparticles (~30 nm). The average thickness of the nanocomposite film and the fibers are 30 μm ? 5 and 300 ? 31 nm, respectively. Electrochemical studies in simulated body fluid and standard immersion corrosion tests have determined that the degradation rate of t
Aims: Since one of the main problems in bone tissue repair is bacterial infections, recently the development of drug-eluting nanocomposite scaffolds for bone regenerative medicine applications has attracted significant attention. Materials & Methods: In the present study, polycaprolactone (PCL)-based composite scaffolds containing 10% V titanium dioxide nanoparticles (21nm), and bioactive glass particles (6?m), were prepared without drug and also loaded by tetracycline hydrochloride (TCH) antibiotic (0.57 and 1.15 mg/mL) through solvent casting method for bone tissue engineering applications. Structural characterizations based on scanning electron microscopy and FTIR analysis were utilized to study the chemical bonds of glass/ceramic partic
Additive manufacturing techniques have evolved novel opportunities for the fabrication of highly‐porous composite scaffolds with well‐controlled and interconnected pore structures which is notably important for tissue engineering. In this work, poly (ԑ‐caprolactone) (PCL)‐based composite scaffolds (average pore diameter of 450 μm, and strut thickness of 400 μm) reinforced with 10 vol% bioactive glass particles (BG; ~6 μm) or TiO2 nanoparticles (~21 nm), containing different concentrations of Tetracycline hydrochloride (TCH) as antimicrobial agent were prepared by 3D printing. In order to investigate the effect of fabrication process and scaffold geometry on the biocompatibility, drug release kinetics and antibacterial
Aims: Since one of the main problems in bone tissue repair is bacterial infections, recently the development of drug-eluting nanocomposite scaffolds for bone regenerative medicine applications has attracted significant attention. Materials & Methods: In the present study, polycaprolactone (PCL)-based composite scaffolds containing 10% V titanium dioxide nanoparticles (21nm), and bioactive glass particles (6?m), were prepared without drug and also loaded by tetracycline hydrochloride (TCH) antibiotic (0.57 and 1.15 mg/mL) through solvent casting method for bone tissue engineering applications. Structural characterizations based on scanning electron microscopy and FTIR analysis were utilized to study the chemical bonds of glass/ceramic partic
Recently, drug-eluting nanofibrous scaffolds have attracted a great attention to enhance the cell differentiation through biomimicking the extracellular matrix (ECM) in regenerative medicine. In this study, electrospun nanocomposite polycaprolactone (PCL)-based scaffolds containing synthesized graphene oxide (GO) nanosheets and osteogenic drugs, i.e. dexamethasone and simvastatin were fabricated. The physicochemical and surface properties of the scaffolds were investigated through FTIR, wettability, pH, and drug release studies. The cell viability, differentiation, and biomineralization were studied on mesenchymal stem cells (MSCs) by Alamar Blue, alkaline phosphatase (ALP) activity, and Alizarin Red-S staining, respectively. Uniformly dist
Additive manufacturing techniques have evolved novel opportunities for the fabrication of highly porous composite scaffolds with well‐controlled and interconnected pore structures which is notably important for tissue engineering. In this work, poly (ε‐caprolactone) (PCL)‐based composite scaffolds (average pore diameter of 450 μm and strut thickness of 400 μm) reinforced with 10 vol% bioactive glass particles (BG; ∼6 μm) or TiO2 nanoparticles (∼21 nm), containing different concentrations of tetracycline hydrochloride (TCH) as an antimicrobial agent, were prepared by 3D printing. In order to investigate the effect of fabrication process and scaffold geometry on the biocompatibility, drug release kinetics, and antibac
The development of bioinks based on shear-thinning and self-healing hydrogels has recently attracted significant attention for constructing complex three-dimensional physiological microenvironments. For extrusion-based bioprinting, it is challenging to provide high structural reliability and resolution of printed structures while protecting cells from shear forces during printing. Herein, we present shear-thinning and printable hydrogels based on silicate nanomaterials, laponite (LA), and glycosaminoglycan nanoparticles (GAGNPs) for bioprinting applications. Nanocomposite hydrogels (GLgels) were rapidly formed within seconds due to the interactions between the negatively charged groups of GAGNPs and the edges of LA. The shear-thinning behav
This work presents a novel melatonin sensor based on unfunctionalized macroporous graphene networks decorated with gold nanoparticles for the differential pulse voltammetric detection of melatonin in pharmaceutical products. Highly porous graphene structures were prepared by metallic template-assisted chemical vapor deposition, and their active surface area and electrocatalytic activity were improved by electrochemical deposition of gold nanoparticles (50–250 nm) on their struts. The graphene-gold electrodes present a highly sensitive performance toward electro-oxidation of melatonin with a wide linear range of 0.05–50 μM, a low detection limit of 0.0082 μM (3σ/m), and a significant sensitivity of 16.219 μA μM–1 cm–2. Therefore
Magnesium-based implants (MBIs) have recently attracted great attention in bone regeneration due to elastic modulus similar to bone. Nevertheless, the degradation rate and hydrogen release of MBIs in the body have to be tackled for practical applications. In the present study, we present a metal organic framework (MOF) nanoplates to reduce the degradation rate of AZ91 magnesium alloy. Zeolitic imidazolate frameworks (ZIF-8) with speci c surface area of 1789 m2. g-1 were prepared by solvothermal methods, and after dispersion in a chitosan solution (10% w/w), the suspesnsion was electrospun on the surface of AZ91 alloy. Studying of the degradation rate in simulated body uid (SBF) by electrochemical analysis including potentiodynamic polarizat
To enhance physicomechanical properties and bioactivity of fibrous membranes for wound dressing and tissue engineering applications, novel composite scaffolds consisting of fibrous mats and thermosensitive hydrogel particles were prepared by concurrent electrospinning and electrospraying technique. The composite scaffolds were composed of keratin/bacterial cellulose fibers (150 ? 43 nm) which are hybridized with hydrogel particles (500 nm to 2 μm) based on nonionic triblock copolymers conjugated with Tragacanth gum (TG). FTIR and H-NMR studies indicated ester reactions between carboxylated copolymers and TG through carbodiimide crosslinker chemistry. The hydrogel particles were uniformly embedded into fibrous network at fiber jun
In order to regenerate bone defects, bioactive hierarchically scaffolds play a key role due to their multilevel porous structure, high surface area, enhanced nutrient transport and diffusion. In this study, novel hierarchically porous silk fibroin (SF) and silk fibroin-bioactive glass (SF-BG) composite were fabricated with controlled architecture and interconnected structure, by combining indirect three-dimensional (3D) inkjet printing and freeze-drying methods. Further, the effect of 45S5 Bioactive glass particles of different sizes (<100 nm and 6 μm) on mechanical strength and cell behavior was investigated. The results demonstrated that the hierarchical structure in this scaffold was composed of two levels of pores in the order of 5
In recent years there has been much interest in development of multifunctional drug delivery systems. In this work, liposomes that contain doxorubicin (Dox), a potent anticancer drug, and graphene nanosheets (GNS) were prepared. The GNSs have excellent optical properties, such as photoluminescence which enables tracking of the liposomes, high absorption in ultra violet region of electromagnetic spectrum which can be exploited in photodynamic and photothermal therapy, and low toxicity to mammalian cells. Nanoliposomes were prepared using the thin film hydration method. Dox and GNSs were loaded to the liposomes during the hydration of the lipid film. Liposomes were characterized and the profile of in vitro drug release, cellular uptake, and c
The delivery of growth factors is often challenging due to their short half-life, low stability, and rapid disactivation. In native tissues, the sulfated residual of glycosaminoglycan (GAG) polymer chains of proteoglycans immobilizes growth factors through the proteoglycans/proteins’ complexation with nanoscale organization. These biological assemblies can influence growth factor-cell surface receptor interactions, cell differentiation, cell-cell signaling, as well as the mechanical properties of the tissues. Here, we introduce a facile procedure to prepare novel biomimetic proteoglycan nanocarriers, based on naturally-derived polymers, for the immobilization and controlled release of growth factors. We developed polyelectrolyte complex n
Aims: Recently, polymer-based nanofibrous scaffolds have attracted great attention due to their significant antibacterial properties in the field of dermatological applications. In this study, a polycaprolactone-based nanofibrous scaffold has been fabricated using the electrospinning method. The aim of this study was to evaluate the antibacterial effect of electrospun nanofibrous structures. Materials and Methods: In this experimental study, the structure and bacterial attachment on polymeric nanofibrous scaffolds were studied by Scanning Electron Microscopy (SEM). In addition, antibacterial properties of nanofibrous scaffolds were studied on two gram-negative bacteria of Escherichia coli and Pseudomonas aeruginosa and two gram-positive bac
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