Fa
  • Ph.D. (2001)

    Clinical Biochemistry

    Medical Biochemistry, Tarbiat Modares University, Tehran, Iran

  • M.Sc. (1990)

    Clinical Biochemistry

    Medical Biochemistry, Tarbiat Modares University, Tehran, Iran

  • B.Sc. (1980)

    Chemistry

    Chemistry, kharazmi University, Tehran, Iran

  • Study of pathogenesis of multiple sclerosis (MS)
  • Molecular diagnosis of chronic, inherited, and genetic diseases
  • Molecular study of the effects of herbal and medicinal compounds in the management and control of diseases
  • Molecular Diagnosis

    Research field: Molecular diagnosis of diseases

    Expert: -

    Phone: 02182883852

    Address: Lab No. 214

  • Genetic and epigenetic research

    Research field: Study of hereditary diseases

    Expert: -

    Phone: 02182884565

    Address: Lab No. 210

In the name of GOD Seyed Alireza Mesbah-Namin, Ph.D., Associate professor Dept. of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University (TMU), Tehran, Iran P.O. Box: 14115- 111, Postal code: 14117-13116 Tel.: 9821-82883570 9821-82884565 Fax: 9821-82883818 9821-82884555 E-mails: mesbahna@modares.ac.ir mesbahnamin@yahoo.com Ph.D in Clinical Biochemistry, from Tarbiat Modares University (TMU), Tehran, Iran, 2001 Title of Thesis: Identification of molecular mutations of Glucose-6-Phosphate Dehydrogenase (G6PD) gene in deficient subjects in Mazandaran province of Iran. Supervisors: Mohammed Noori-Daloii (Iran) and Tom Vulliamy (UK) M.Sc. in Clinical Biochemistry, from TMU, Tehran, Iran, 1989. Title of Thesis: Isolation of Nerve Growth Factor (NGF) by HPLC from mice submaxillary glands. Supervisor: Taki Tiraihi (Iran) B.Sc. in Chemistry, from Teacher Training (Kharazmi) University, Tehran, Iran, 1984 Sabbatical leave On sabbatical leave, Dept. of Molecular Medicine and Max-Plank Research Group for stem cell aging , Ulm University, Ulm , Germany , 21st July 2010 31st Jan 2011. (Supported by Ministry of Science, Research and Technology of Iran and TMU, Tehran, Iran). My interests could be divided into the 4 categories which are as follows: Molecular diagnosis of inherited diseases Genetics and epigenetics approach of investigation on the nervous system abnormalities Telomere and telomerase in aging process Molecular diagnosis of infertility Scientific Member of the some Societies such as: Biochemical Society of Islamic Republic of Iran Member of Iranian genetic society, Tehran, Iran Member of Iranian society for Biotechnology, Tehran, Iran Member of Iranian society for Trace Element Research (ISTER) Member of Biosafety Committee of Tarbiat Modares University, Tehran, Iran Member of Biosafety Committee of the Ministry of Science, Research and Technology of Islamic Republic of Iran

Contact

Curriculum Vitae (CV)

Attenuation of aquaporin‐3 may be contributing to low sperm motility and is associated with activated caspase‐3 in asthenozoospermic individuals

P Mohammadi, SA Mesbah‐Namin, M Movahedin
Journal Paper , , {Pages }

Abstract

Analysis of changes in the expression pattern of miR-326 and miR-145 during storage of platelet concentrate in blood bank condition and its relationship with some markers of …

M Norouzi, SA Mesbah-Namin, MR Deyhim
Journal Paper , , {Pages }

Abstract

Protective effect of L-carnitine on platelet apoptosis during storage of platelet concentrate

Mohammad Reza Deyhim, Seyed A Mesbah-Namin, Fahimeh Khoshnaghsh
Journal PaperTransfusion Clinique et Biologique , 2020 June 13, {Pages }

Abstract

Background: Platelet apoptosis is considered as one of the important factors involved in platelet storage lesion (PSL) and affect the quality of platelets during storage. The beneficial effect of L-carnitine (LC) on platelet apoptosis during platelet concentrates (PCs) storage has not been fully investigated. The aim of this study was to evaluate the effects of LC on platelets of PC regarding their apoptosis markers during storage.Methods: Ten PCs from healthy donors were investigated in this study. PCs were prepared by platelet rich plasma (PRP) method and stored at 22?2? C with gentle agitation during storage. The effects of LC (15 mM) on the platelet apoptosis were assessed by analyzing different indicative presence or absence of LC. Sam

A large deletion, spanning exons 1 to 25 of F8 gene, and a high-titer factor VIII inhibitor, in severe hemophilia A.

Sayed Hamid Mousavi, Seyed Alireza Mesbah-Namin, Sirous Zeinali, Mohammad Jazebi, Ali Dabbagh, Sayed Mohammad Reza Hosseini, Motlagh F Zafarghandi, Yavar Shiravand, Akbar Dorgalaleh
Journal PaperInternational journal of laboratory hematology , 2020 March 3, {Pages }

Abstract

Author information: (1)Department of the Clinical Biochemistry, Faculty of Medical Sciences, Kateb University, Kabul, Afghanistan. (2)Afghanistan National Charity Organization for Special Diseases (ANCOSD), Kabul, Afghanistan. (3)Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. (4)Iranian Molecular Medicine Network, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. (5)Iranian Comprehensive Hemophilia Care Center (ICHCC), Tehran, Iran. (6)Anesthesiology Department, Anesthesiology Research Center, Shahid Beheshti University of Medicine, Tehran, Iran. (7)Department of Public Health, Ghalib University, Kabul, Afghanistan. (8)Dr. Zeinali's Medical Genetics La

Immunomodulatory Effects of Calcitriol through DNA Methylation Alteration of FOXP3 in the CD4+ T Cells of Mice

Mona Oraei, Sama Bitarafan, Seyed Alireza Mesbah-Namin, Ali Noori-Zadeh, Fatemeh Mansouri, Karim Parastouei, Ali Anissian, Mir Saeed Yekaninejad, Maryam Hajizadeh, Ali Akbar Saboor-Yaraghi
Journal PaperIranian Journal of Allergy, Asthma and Immunology , 2020 October 4, {Pages 08-Jan }

Abstract

Vitamin D plays a variety of physiological functions, such as regulating mineral homeostasis. More recently, it has emerged as an immunomodulator player, affecting several types of immune cells, such as regulatory T (Treg) cells. It has been reported that vitamin D exerts some mediatory effects through an epigenetic mechanism. In this study, the impacts of calcitriol, the active form of vitamin D, on the methylation of the conserved non-coding sequence 2 (CNS2) region of the forkhead box P3 (Foxp3) gene promoter, were evaluated.

Mitochondrial Dysfunction in EAE Mice Brains and Impact of HIF1-α Induction to Compensate Energy Loss

Mahboobeh Mosavimehr, Seyed Alireza Mesbah-Namin
Journal PaperArchives of Neuroscience , Volume 7 , Issue 4, 2020 October 31, {Pages }

Abstract

Background: Mitochondrial dysfunction may be involved in the process of degradation and death of gray matter cells of the central nervous system (CNS) in patients with multiple sclerosis (MS). MS is known as a chronic, progressive demyelinating disease of the CNS. Objectives: Experimental autoimmune encephalomyelitis (EAE) mouse model of MS is the best method for extracting data trend for diagnosing this disorder. The aim of this study was to evaluate the specific activity of the Cytochrome oxidase (COX), ATP, and hypoxia-inducible factor 1 alpha (HIF-1α) in brain tissues of the EAE mice model. Methods: Twenty-one female mice (C57BL/6) were used, 9 for inducing the EAE model and 6 for each of both negative and sham control groups. The spec

DNA methyltransferase inhibitor 5-azacytidine in high dose promotes ultrastructural maturation of cardiomyocyte

Mona Saheli, Vahid Pirhajati Mahabadi, Seyed Alireza Mesbah-Namin, Alexander Seifalian, Zahra Bagheri-Hosseinabadi
Journal PaperStem Cell Investigation , Volume 7 , 2020 January , {Pages }

Abstract

BackgroundThe adult human heart muscle cells, cardiomyocytes are not capable of regenerate after injury. Stem cells are a powerful means for future regenerative medicine because of their capacity for self-renewal and multipotency. Several studies have reported the cardiogenic potential in human adipose tissue-derived stem cells (ADSCs) differentiation, but there is still no efficient protocol for the induction of cardiac differentiation by 5-azacytidine (5-Aza). The present study involves characterization and mainly, the ultrastructure of ADSCs derived cardiomyocyte-like cells.MethodsThe cultured ADSCs were treated with 50 ?M 5-Aza for 24 hours, followed by a 10-week extension. At different time points, cardiomyocyte-like cells were assesse

A large deletion, spanning exons 1 to 25 of F8 gene, and a high-titer factor VIII inhibitor, in severe hemophilia A

SH Mousavi, SA Mesbah-Namin, S Zeinali, M Jazebi, A Dabbagh, ...
Journal Paper , , {Pages }

Abstract

Factor XIII Deficiency in Western Afghanistan due to a Novel F13A Gene Mutation

SH Mousavi, S Zeinali, SA Mesbah‐Namin, M Shams, A Dorgalaleh
Journal Paper , , {Pages }

Abstract

Betalain-and betacyanin-rich supplements’ impacts on the PBMC SIRT1 and LOX1 genes expression and Sirtuin-1 protein levels in coronary artery disease patients: A pilot?…

Parisa Rahimi, Seyed Alireza Mesbah-Namin, Alireza Ostadrahimi, Ahmad Separham, Mohammad Asghari Jafarabadi
Journal PaperJournal of Functional Foods , Volume 60 , 2019 September 1, {Pages 103401 }

Abstract

Activation of Sirtuin-1 (SIRT1) is a considered candidate for the prevention of cardiovascular diseases. SIRT1 as a longevity factor regulates human cell lifespan and influences aspects of age-dependent atherosclerosis. Betalains can significantly increase the lifespan of?Caenorhabditis elegans. This effect may be agreeable with activation of SIRT1. Thus, this study investigates the effects of betalains on SIRT1 and Lectin-like Oxidized LDL Receptor 1 (LOX1) expression in coronary artery disease patients. Participants received three treatments (a betalains-rich supplement of red beetroot, a betacyanins-rich supplement of Opuntia stricta and a placebo; daily for two weeks) on three occasions which separated by washout periods. A notable elev

Factor XIII Deficiency in Western Afghanistan due to a Novel F13A Gene Mutation.

Sayed Hamid Mousavi, Sirous Zeinali, Seyed Alireza Mesbah-Namin, Mahmood Shams, Akbar Dorgalaleh
Journal PaperInternational journal of laboratory hematology , 2019 May , {Pages }

Abstract

Author: Mousavi SH, Journal: International journal of laboratory hematology[2019/05].

Determinants of Quality of Life in Children and Adolescents With Hemophilia in Kabul, Afghanistan: First Report.

Sayed Hamid Mousavi, Mohammad Saaid Dayer, Fatemeh Pourhaji, Mohammad-Hossein Delshad, Seyed Alireza Mesbah-Namin
Journal PaperArchives of Iranian Medicine (AIM) , Volume 22 , Issue 7, 2019 July 1, {Pages }

Abstract

Background: Hemophilia is a rare inherited disorder associated with abnormal repeated bleeding and debilitating joint pain due to deficiency in coagulating factors VIII and IX. This study aimed to provide an updated account on the health-related quality of life (HRQoL) in children with hemophilia in Afghanistan. Methods: This cross-sectional study included 65 randomly selected hemophiliacs out of 350 children registered with the Afghanistan Hemophilia Patient Association (AHPA). The patients were 8--16 years old and voluntarily entered the study. Data were collected through a demographic questionnaire and a Persian version of Haemo-QoL Questionnaire (short version) for children aged 8-16 years. Results: The patients' age averaged 12.9?3.9 y

Effects of Betalains and Betacyanins on Atherogenic Risk Factors in Patients with Atherosclerotic Cardiovascular Disease

Parisa Rahimi, Seyed Alireza Mesbah-Namin, A Ostadrahimi, Saeed Abedimanesh, Ahmad Separham
Journal PaperFood & Function , 2019 January , {Pages }

Abstract

This study evaluated the potential impacts of supplementation with betalain-rich extracts of foods on some atherosclerotic risk factors in coronary artery disease patients. During an acute phase, 48 male patients received about 50 mg betalain/betacyanin, and their blood and urine samples collected at 3, 8, and 24 hours after supplementations. Also, in a pilot randomized crossover trial, these participants were allocated to two-week interventions (a betacyanin-rich supplement of Opuntia stricta, a betalain-rich supplement of red beetroot and a placebo) with two-week washout periods. Then, their plasma samples were collected at the baseline and after two-weeks’ periods. The concentration of betanin in plasma and urine samples were determine

Betalain-and betacyanin-rich supplements’ impacts on the PBMC SIRT1 and LOX1 genes expression and Sirtuin-1 protein levels in coronary artery disease patients: A pilot …

P Rahimi, SA Mesbah-Namin, A Ostadrahimi, A Separham, ...
Journal Paper , , {Pages }

Abstract

Determinants of Quality of Life in Children and Adolescents With Hemophilia in Kabul, Afghanistan

SH Mousavi, MS Dayer, F Pourhaji, MH Delshad, SA Mesbah-Namin
Journal Paper , , {Pages }

Abstract

Effects of betalains on atherogenic risk factors in patients with atherosclerotic cardiovascular disease

P Rahimi, SA Mesbah-Namin, A Ostadrahimi, S Abedimanesh, ...
Journal Paper , , {Pages }

Abstract

Human wild-type superoxide dismutase 1 gene delivery to rat bone marrow stromal cells: its importance and potential future trends

Mohsen Abedi, Seyed Alireza Mesbah-Namin, Ali Noori-Zadeh, Taki Tiraihi, Taher Taheri
Journal PaperIranian Journal of Basic Medical Sciences , 2018 May 24, {Pages }

Abstract

Objective (s): Human superoxide dismutase 1 (SOD1) is the cytosolic form of this enzyme it detoxifies superoxide anions and attenuates their toxicities and concomitant detrimental effects on the cells. It is believed that the amount of these enzymes present in the oxidative stress-induced diseases is crucial for preventing disease progression. Transfection of rat bone marrow stromal cells (BMSCs) by a constructed vector carrying the human wild-type SOD1 gene, a non-viral gene transfer method, was the main aim of this study.Materials and Methods: For this purpose, the rat BMSCs were transfected with the vector using Turbofect reagent and then stabilized. Western-blot and real-time PCR were also used for evaluation of SOD1 expression.Results:

Anti-aging protective effect of L-carnitine as clinical agent in regenerative medicine through increasing telomerase activity and change in the hTERT promoter CpG island?…

Raheleh Farahzadi, Ezzatollah Fathi, Seyed Alireza Mesbah-Namin, Nosratollah Zarghami
Journal PaperTissue and Cell , Volume 54 , 2018 October 1, {Pages 105-113 }

Abstract

The identification of factors that reduce the senescent tendency of the mesenchymal stem cells (MSCs) upon expansion has great potential for cellular therapies in regenerative medicine. Previous studies have shown the aging protective effect of L-carnitine (LC). On the other hand, reduction in proliferation potential and age-dependent decline in number and functions of MSCs were accompanied by telomere shortening, reduction in telomerase activity and epigenetic changes. The aim of this study was to evaluate the effects of LC on aging of MSCs through telomerase activity assessment and the investigation of methylation status of the hTERT gene promoter. Telomerase activity and hTERT promoter methylation investigation was performed with PCR-ELI

A Comparative Study of the Effects of Sodium Selenite and Glutathione Mono Ethyl Ester on Aged Adipose-Derived Stem Cells: The Telomerase and Cellular Respo...

Najmeh Aminizadeh, Taki Tiraihi, Seyed Alireza Mesbah-Namin, Taher Taheri
Journal PaperRejuvenation research , Volume 21 , Issue 1, 2018 February 1, {Pages 29-36 }

Abstract

The proliferation and differentiation potential of adipose-derived stem cells (ADSCs) decline with aging. Moreover, Alzheimer's disease is associated with progressive decline in cholinergic neurons. The purpose of this study is to enhance the proliferation potential of aged rat ADSCs and their differentiation into cholinergic neurons. The ADSCs were collected from aged male rats cultured and treated with different concentrations of sodium selenite for 3 days or glutathione mono ethyl ester (GSH-MEE) for 1 day. Incubating the ADSCs with 27 nM sodium selenite for 3 days significantly increased the relative cell proliferation, compared with the control, without any change in the telomerase activity, the related telomerase gene expression, and

Betalains, the nature-inspired pigments, in health and diseases

Parisa Rahimi, Saeed Abedimanesh, Seyed Alireza Mesbah Namin, Alireza Ostadrahimi
Journal Paper , Issue just-accepted, 2018 May 26, {Pages 00-00 }

Abstract

Betalains are unique nitrogen-containing pigments found exclusively in families of the Caryophyllales order and some higher order fungi, where they replace anthocyanin pigments. Betalains, consisting of betacyanins and betaxanthins are generally used as color additives in food. This review discusses on the favorable effects of acute and chronic consumption of betalains, whose edible sources consist primarily of red beetroots (Beta vulgaris) and prickly pears (fruit of the Opuntia genus of cacti). Moreover, it encompasses in vivo and in vitro studies about the bioavailability and bioaccessibility of betanin and indicaxanthin. It seems that treatment with betalains and betalain-rich diets is not only non-toxic but could also prove to be a pro

Current Teaching

  • MS.c.

    Biochemistry and Molecular Diagnosis

Teaching History

  • MS.c.

    Advanced Biochemistry of Tissues

  • MS.c.

    Laboratory Methods and Application of Instruments

  • 2021
    Sabzipour, Hassan
    The effect of silymarin on the expression level of the liver X receptor gene and its related genes(ABCA1 and PPARa) and level of the TNFa and IL1B inflammatory factors in the liver of multiple sclerosis mouse model (EAE)
  • 2021
    Moazami goodarzi, Behnaz
  • 2014
    Parvaz, Eskandar
    Evaluation of expression and methylation status of Histone acetyltransferase EP300 promoter gene and its enzyme mass and activity in patients with ankylosing spondylitis (AS) comparison with normal group
  • 2017
    Mosadeghi, Parvin
  • 2019
    Korani, Bahareh

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