Department of Medical Biochemistry (1990 - Present)
Clinical Biochemistry
Medical Biochemistry, Tarbiat Modares University, Tehran, Iran
Clinical Biochemistry
Medical Biochemistry, Tarbiat Modares University, Tehran, Iran
Chemistry
Chemistry, kharazmi University, Tehran, Iran
In the name of GOD Seyed Alireza Mesbah-Namin, Ph.D., Associate professor Dept. of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University (TMU), Tehran, Iran P.O. Box: 14115- 111, Postal code: 14117-13116 Tel.: 9821-82883570 9821-82884565 Fax: 9821-82883818 9821-82884555 E-mails: mesbahna@modares.ac.ir mesbahnamin@yahoo.com Ph.D in Clinical Biochemistry, from Tarbiat Modares University (TMU), Tehran, Iran, 2001 Title of Thesis: Identification of molecular mutations of Glucose-6-Phosphate Dehydrogenase (G6PD) gene in deficient subjects in Mazandaran province of Iran. Supervisors: Mohammed Noori-Daloii (Iran) and Tom Vulliamy (UK) M.Sc. in Clinical Biochemistry, from TMU, Tehran, Iran, 1989. Title of Thesis: Isolation of Nerve Growth Factor (NGF) by HPLC from mice submaxillary glands. Supervisor: Taki Tiraihi (Iran) B.Sc. in Chemistry, from Teacher Training (Kharazmi) University, Tehran, Iran, 1984 Sabbatical leave On sabbatical leave, Dept. of Molecular Medicine and Max-Plank Research Group for stem cell aging , Ulm University, Ulm , Germany , 21st July 2010 31st Jan 2011. (Supported by Ministry of Science, Research and Technology of Iran and TMU, Tehran, Iran). My interests could be divided into the 4 categories which are as follows: Molecular diagnosis of inherited diseases Genetics and epigenetics approach of investigation on the nervous system abnormalities Telomere and telomerase in aging process Molecular diagnosis of infertility Scientific Member of the some Societies such as: Biochemical Society of Islamic Republic of Iran Member of Iranian genetic society, Tehran, Iran Member of Iranian society for Biotechnology, Tehran, Iran Member of Iranian society for Trace Element Research (ISTER) Member of Biosafety Committee of Tarbiat Modares University, Tehran, Iran Member of Biosafety Committee of the Ministry of Science, Research and Technology of Islamic Republic of Iran
Background: Platelet apoptosis is considered as one of the important factors involved in platelet storage lesion (PSL) and affect the quality of platelets during storage. The beneficial effect of L-carnitine (LC) on platelet apoptosis during platelet concentrates (PCs) storage has not been fully investigated. The aim of this study was to evaluate the effects of LC on platelets of PC regarding their apoptosis markers during storage.Methods: Ten PCs from healthy donors were investigated in this study. PCs were prepared by platelet rich plasma (PRP) method and stored at 22?2? C with gentle agitation during storage. The effects of LC (15 mM) on the platelet apoptosis were assessed by analyzing different indicative presence or absence of LC. Sam
Author information: (1)Department of the Clinical Biochemistry, Faculty of Medical Sciences, Kateb University, Kabul, Afghanistan. (2)Afghanistan National Charity Organization for Special Diseases (ANCOSD), Kabul, Afghanistan. (3)Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. (4)Iranian Molecular Medicine Network, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. (5)Iranian Comprehensive Hemophilia Care Center (ICHCC), Tehran, Iran. (6)Anesthesiology Department, Anesthesiology Research Center, Shahid Beheshti University of Medicine, Tehran, Iran. (7)Department of Public Health, Ghalib University, Kabul, Afghanistan. (8)Dr. Zeinali's Medical Genetics La
Vitamin D plays a variety of physiological functions, such as regulating mineral homeostasis. More recently, it has emerged as an immunomodulator player, affecting several types of immune cells, such as regulatory T (Treg) cells. It has been reported that vitamin D exerts some mediatory effects through an epigenetic mechanism. In this study, the impacts of calcitriol, the active form of vitamin D, on the methylation of the conserved non-coding sequence 2 (CNS2) region of the forkhead box P3 (Foxp3) gene promoter, were evaluated.
Background: Mitochondrial dysfunction may be involved in the process of degradation and death of gray matter cells of the central nervous system (CNS) in patients with multiple sclerosis (MS). MS is known as a chronic, progressive demyelinating disease of the CNS. Objectives: Experimental autoimmune encephalomyelitis (EAE) mouse model of MS is the best method for extracting data trend for diagnosing this disorder. The aim of this study was to evaluate the specific activity of the Cytochrome oxidase (COX), ATP, and hypoxia-inducible factor 1 alpha (HIF-1α) in brain tissues of the EAE mice model. Methods: Twenty-one female mice (C57BL/6) were used, 9 for inducing the EAE model and 6 for each of both negative and sham control groups. The spec
BackgroundThe adult human heart muscle cells, cardiomyocytes are not capable of regenerate after injury. Stem cells are a powerful means for future regenerative medicine because of their capacity for self-renewal and multipotency. Several studies have reported the cardiogenic potential in human adipose tissue-derived stem cells (ADSCs) differentiation, but there is still no efficient protocol for the induction of cardiac differentiation by 5-azacytidine (5-Aza). The present study involves characterization and mainly, the ultrastructure of ADSCs derived cardiomyocyte-like cells.MethodsThe cultured ADSCs were treated with 50 ?M 5-Aza for 24 hours, followed by a 10-week extension. At different time points, cardiomyocyte-like cells were assesse
Activation of Sirtuin-1 (SIRT1) is a considered candidate for the prevention of cardiovascular diseases. SIRT1 as a longevity factor regulates human cell lifespan and influences aspects of age-dependent atherosclerosis. Betalains can significantly increase the lifespan of?Caenorhabditis elegans. This effect may be agreeable with activation of SIRT1. Thus, this study investigates the effects of betalains on SIRT1 and Lectin-like Oxidized LDL Receptor 1 (LOX1) expression in coronary artery disease patients. Participants received three treatments (a betalains-rich supplement of red beetroot, a betacyanins-rich supplement of Opuntia stricta and a placebo; daily for two weeks) on three occasions which separated by washout periods. A notable elev
Author: Mousavi SH, Journal: International journal of laboratory hematology[2019/05].
Background: Hemophilia is a rare inherited disorder associated with abnormal repeated bleeding and debilitating joint pain due to deficiency in coagulating factors VIII and IX. This study aimed to provide an updated account on the health-related quality of life (HRQoL) in children with hemophilia in Afghanistan. Methods: This cross-sectional study included 65 randomly selected hemophiliacs out of 350 children registered with the Afghanistan Hemophilia Patient Association (AHPA). The patients were 8--16 years old and voluntarily entered the study. Data were collected through a demographic questionnaire and a Persian version of Haemo-QoL Questionnaire (short version) for children aged 8-16 years. Results: The patients' age averaged 12.9?3.9 y
This study evaluated the potential impacts of supplementation with betalain-rich extracts of foods on some atherosclerotic risk factors in coronary artery disease patients. During an acute phase, 48 male patients received about 50 mg betalain/betacyanin, and their blood and urine samples collected at 3, 8, and 24 hours after supplementations. Also, in a pilot randomized crossover trial, these participants were allocated to two-week interventions (a betacyanin-rich supplement of Opuntia stricta, a betalain-rich supplement of red beetroot and a placebo) with two-week washout periods. Then, their plasma samples were collected at the baseline and after two-weeks’ periods. The concentration of betanin in plasma and urine samples were determine
Objective (s): Human superoxide dismutase 1 (SOD1) is the cytosolic form of this enzyme it detoxifies superoxide anions and attenuates their toxicities and concomitant detrimental effects on the cells. It is believed that the amount of these enzymes present in the oxidative stress-induced diseases is crucial for preventing disease progression. Transfection of rat bone marrow stromal cells (BMSCs) by a constructed vector carrying the human wild-type SOD1 gene, a non-viral gene transfer method, was the main aim of this study.Materials and Methods: For this purpose, the rat BMSCs were transfected with the vector using Turbofect reagent and then stabilized. Western-blot and real-time PCR were also used for evaluation of SOD1 expression.Results:
The identification of factors that reduce the senescent tendency of the mesenchymal stem cells (MSCs) upon expansion has great potential for cellular therapies in regenerative medicine. Previous studies have shown the aging protective effect of L-carnitine (LC). On the other hand, reduction in proliferation potential and age-dependent decline in number and functions of MSCs were accompanied by telomere shortening, reduction in telomerase activity and epigenetic changes. The aim of this study was to evaluate the effects of LC on aging of MSCs through telomerase activity assessment and the investigation of methylation status of the hTERT gene promoter. Telomerase activity and hTERT promoter methylation investigation was performed with PCR-ELI
The proliferation and differentiation potential of adipose-derived stem cells (ADSCs) decline with aging. Moreover, Alzheimer's disease is associated with progressive decline in cholinergic neurons. The purpose of this study is to enhance the proliferation potential of aged rat ADSCs and their differentiation into cholinergic neurons. The ADSCs were collected from aged male rats cultured and treated with different concentrations of sodium selenite for 3 days or glutathione mono ethyl ester (GSH-MEE) for 1 day. Incubating the ADSCs with 27 nM sodium selenite for 3 days significantly increased the relative cell proliferation, compared with the control, without any change in the telomerase activity, the related telomerase gene expression, and
Betalains are unique nitrogen-containing pigments found exclusively in families of the Caryophyllales order and some higher order fungi, where they replace anthocyanin pigments. Betalains, consisting of betacyanins and betaxanthins are generally used as color additives in food. This review discusses on the favorable effects of acute and chronic consumption of betalains, whose edible sources consist primarily of red beetroots (Beta vulgaris) and prickly pears (fruit of the Opuntia genus of cacti). Moreover, it encompasses in vivo and in vitro studies about the bioavailability and bioaccessibility of betanin and indicaxanthin. It seems that treatment with betalains and betalain-rich diets is not only non-toxic but could also prove to be a pro
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