Department of Medical Entomology (2011 - Present)
Medical Entomology and Carrier Control - Medical Entomology
, Newcastle Upon Thine, England
Agricultural insects - Ecology and biological control
, Newcastle Upon Thine, England
Agricultural Engineering, Plant Protection
, Chamran martyr of Ahwaz University,
Research field:
Expert:
Phone:
Address:
Research field:
Expert:
Phone:
Address:
Mohammad Saaid Dayer has completed his PhD in 2004 from University of Newcastle upon Tyne in UK and since then he working as a lecturer in the Department of Parasitology and Medical Entomology of Tarbiat Modares University in Tehran (Iran). As an insect pathologist, one of his research field of interest is biological control of medically important arthropods using natural products including medicinal plants. He has published more than 35 papers in reputed journals and presented papers in many international scientific events.
Coronavirus (COVID-19) outbreak in late 2019 and 2020 comprises a serious and more likely a pandemic threat worldwide. Given that the disease has not approved vaccines or drugs up to now, any efforts for drug design and or clinical trails of old drugs based on their mechanism of action are worthy and creditable in such circumstances. Experienced docking experiments using the newly released coordinate structure for COVID-19 protease as a receptor and thoughtfully selected chemicals among antiviral and antibiotics drugs as ligands may be leading in this context. We selected nine drugs from HIV-1 protease inhibitors and twenty-one candidates from anti bronchitis drugs based on their chemical structures and enrolled them in blind and active sit
The disease of COVID-19 comprises the most serious against human health worldwide with a high rate of virulence and mortality. The disease is caused by the 2019-nCoV virus from the beta coronavirus family. The virus makes use of its surface glycoprotein named S protein or spike to enter the human cells. The virus attached to its receptor named angiotensin-converting enzyme 2 on host cells surface via its receptor-binding domain and its fusion is mediated by cleavage at S2'site that is carried out by surface protease. Vaccines or drugs interfering with S protein binding or cleavage sites could be considered as drugs to get rid of the infection. In the current work and though docking and molecular dynamic experiments we have checked more than
Background: Non-alcoholic fatty liver is a chronic lifestyle disease caused by low physical activity and high food intake, which exposes patients to obesity and diabetes mellitus. High incidences and serious consequences of the disease have attracted a great number of new researches. elucidating mechanism for gender dependent risk of the disease is the main endeavor of this study.Methods: In the present study 286 male and 324 female individuals, aged 45?5 years with 13?1.5 and 8?2 mmHg (systolic/diastolic) blood pressure and BMI exceeding 22 were examined. The patients were non-diabetic with increased plasma concentrations of hepatic enzymes, their ratio of aspartate amino transferase (AST) to alanine amino transferase (ALT) was under unity
Background: The close physiological and biochemical relationships between insulin/thyroid hormones and intermediary metabolism, as well as hepatic homeostasis, are well documented. Apart from significant changes in thyroid hormones levels and altered insulin secretion or resistance, there is no consistency regarding the presence of hepatic storage diseases and fatty liver in hypothyroid patients. Objectives: The main objective of the current study was to evaluate the effect of experimental hypothyroidism on insulin level and histological alterations in the liver such as changes in lipid and glycogen reservoirs. Methods: In this study, 20 adult male Wistar rats were assigned to two similar groups including control and hypothyroid. Experiment
Zinc ion is the second essential element in living organisms and is necessary for lots of enzymes activity eg alkaline phosphatase and lactate dehydrogenase. This ion also takes part in biological processes as human growth, immune response, and nerve function. Zinc deficiency causes significant decrease in serum alkaline phosphatase or increase in aspartate aminotransferase and alanine aminotransferase activity. Increase in these two later enzymes, in turn, is an indicator of tissue damage even though there are controversies among researchers. Accordingly, we decided to study the effect of 0. 6 gm/L of zinc sulfate in drinking water in a period of 3 months treatment on serum activities of hepatic enzymes in adult rats. Twenty female rats we
Cardiovascular disease and myocardial infarction comprise the leading causes of more than half of the total death often among elderly people. Psychological stresses, imbalanced diet, sedentary lifestyle, obesity, tobacco, alcohol, and metabolic diseases such as hypothyroidism and diabetes mellitus are the main risk factors for the disease. In order to better understand the underlying risk factor for the disease we performed complete analyses of biochemical factors in sera of obese, non-diabetic and non-hypothyroid male (174) and female patients (213). Among the determinant parameters, TSH, BUN, Creatinine, AST, ALT, FBS, LDL, and TG/HDL ratio, which show correlation and suit structural equation models were selected for path analysis. The av
Five dinuclear organotin(IV) complexes, R4Sn2La (R = Me, Ph) and R4Sn2Lb (R = Me, Ph and Bu) have been synthesized from reaction of R2SnCl2 with 2,4′- and 2,2′-bis-substituted diphenylamine arylidene hydrazones, H4La and H4Lb, respectively. The synthesized compounds have been investigated by elemental analysis and IR, 1H NMR, and 119Sn NMR spectroscopy. The structures of Me4Sn2Lb and Ph4Sn2Lb have been also confirmed by X-ray crystallography. The results show that the fully deprotonated bis-hydrazone ligand provides two contiguous ONO tridentate domains that coordinate to the two SnR2 moieties in the enolate form. Each tin atom in the complexes adopts a five-coordinate environment. Ligands and complexes showed no antibacterial a
Abstract Objective: Multiple Sclerosis, a chronic autoimmune neurodegenerative inflammatory disease, is the main reason of physical disability in young adults. Have been many efforts to find a better understanding of disease and subsequently effective drugs. Surprisingly Angiotensin converting enzyme (ACE) inhibitors have recently attracted attentions for their immunomodulatory effects, besides to their known effectiveness on hypertension. Captopril is one of the well-known ACE inhibitors which is used as an effective drug, for hypertension and congestive heart failure. Inconsistent results have been reported about the effect of captopril on cytokines. Material and Methods: Blood samples were collected from 20 patients diagnosed as MS patie
Abstract Objective: Multiple Sclerosis, a chronic autoimmune neurodegenerative inflammatory disease, is the main reason of physical disability in young adults. More than 2 million people are affected worldwide and the rate of the disease is rather high, about 70 of 100000 in Tehran and Isfahan. Ascorbic Acid, known as vitamin C, is one of important required vitamins for humans, which must be received by food. One of the probable characteristics is anti-inflammatory activity. Since Cytokines as the key molecules in the process of inflammation and autoimmune diseases, can be appropriate targets to follow the process, have been used to check the effect of compounds on inflammation. Inconsistent results have been reported about the effect of ca
Insulin as a small molecule with 51 residues is an interesting model useful in studying protein misfolding of neurodegenerative amyloid proteins. Investigating zinc effects on insulin misfolding and aggregation triggered by 80% ethanol is the main objective of the present work. Using different methods of turbidity measurement, examining thioflavin T fluorescence changes during insulin aggregation, and conducting Far-UV circular dichroism spectroscopy of the process, we studied insulin aggregations in the presence of micromolar and millimolar concentrations of zinc ions to shed light on the mechanism of misfolding in these circumstances. Our findings confirmed that millimolar concentrations of zinc protect insulin integrity against acidic pH
Background: The severe acute respiratory syndrome (SARS) is a life threatening viral infection caused by a positive, single stranded RNA virus from the enveloped coronaviruse family. Associated with fever, cough, and respiratory complications, the illness causes more than 15% mortality worldwide. So far, there is no remedy for the illness except supportive treatments. However, the main viral proteinase has recently been regarded as a suitable target for drug design against SARS infection due to its vital role in polyproteins processing necessary for coronavirus reproduction.Objectives: The present in silico study was designed to evaluate the effects of anti HIV-1 proteases inhibitors, approved for clinical applications by US FDA, on SARS pr
Background: Androgenetic alopecia is the main cause of hair loss and common baldness that affects psychological more than physiological aspects of people’s lives. Studies have shown that this multi factorial disorder is initiated by androgens secretion in pubertal period, minerals limitations, autoimmunity, mental stress, genetic predisposition and some alterations in hematological factors.Objectives: The aim of this study was to evaluate the involvement of hematologic parameters in this disease using a case control study design.Methods: In this case-controlled study, two groups each of 80 individuals with androgenetic alopecia were voluntarily included in the study based on their medical histories and clinical examinations and subjected
Background: Percutaneous nephrolithotomy (PCNL) has been established as a minimally invasive treatment option for removal of kidney stones. The aim of this research was to compare complications and surgical outcomes of standard PCNL with tubeless PCNL.Methods: In this double-blind randomized controlled trial, 50 consecutive patients with kidney stone were randomly assigned to intervention and control groups. In the control group, a nephrostomy was placed at the end of PCNL and in the intervention group, nephrostomy was omitted. Incidence of fever, hospital stay, analgesic requirement, blood transfusion, urinary leakage, and patient’s satisfaction were compared between the 2 groups.Results: Pain score was significantly lower in the tubeles
BackgroundDrug design against human immunodeficiency virus type 1 (HIV-1) integrase through its mechanistic study is of great interest in the area in biological research. The main obstacle in this area is the absence of the full-length crystal structure for HIV-1 integrase to be used as a model. A complete structure, similar to HIV-1 of a prototype foamy virus integrase in complex with DNA, including all conservative residues, is available and has been extensively used in recent investigations.ObjectivesThe aim of this study was to determine whether the above model is precisely representative of HIV-1 integrase. This would critically determine the success of any designed drug using the model in deactivation of integrase and AIDS treatment.M
Background: Protein misfolding and aggregation are the main causes of serious diseases; thus the study of mechanism and effective factors is necessary to find the cure. Since most of the proteins have the ability to produce aggregations, available and non-infectious proteins can be studied as models. Insulin is one of the best models in this field.Methods: The current study evaluated the effect of three temperatures of 0 C, 37 C and 47 C and neutral and acidic pH on insulin structure and misfolding by silico simulation. An insulin structure obtained by nuclear magnetic resonance (NMR) spectroscopy is simulated by GROMACS package under different conditions. The secondary structure of insulin amino acids was studied in acidic and neutral cond
Application of newly designed enzyme inhibitors against viral enzymes is one of the modern and effective approaches in viral diseases treatment. Such inhibitors, by inactivating vital enzymes and interrupting viral proliferation, prevent the spread of infection. In this context, the HIV-1 integrase is of special importance. So far, three inhibitors against integrase were designed, approved and used clinically named: Raltegravir, Elvitegravir, and Dolutegravir. In present work and in order to study the action mechanisms for these inhibitors we at first performed serial docking experiments to find the best binding sites for these inhibitors and to extract their complexes with integrase. Next we simulated these complexes for 10ns period at nat
no record found