Fa
  • Ph.D. (2008)

    Medical Bacteriology

    , Isfahan University of Medical Sciences, Isfahan, Iran

  • M.Sc. (2003)

    Medical Microbiology

    , Tehran University of Medical Sciences,

  • B.Sc. (1998)

    Biology - Microbiology

    , Al-Zahra University / QA /,

  • Application of Nanotechnology Designing Bacterial Vaccines, Designing Nano Biosensors, New systems of tracing and diagnosing bacterial infections
  • Molecular epidemiology, Genotyping and Toxigenotyping of Intestinal Bacteria and ulcerative colitis.
  • laboratory

    Research field: Bacterial Vaccines, Designing Nano Biosensors,Molecular epidemiology

    Expert:

    Phone: 02182884558

    Address: Ground floor of the medical building , room No 7

Contact

Curriculum Vitae (CV)

High prevalence of Campylobacter jejuni CC21 and CC257 clonal complexes in children with gastroenteritis in Tehran, Iran

Mahnaz Sarhangi, Bita Bakhshi, Shahin Najar Peeraeyeh
Journal PaperBMC Infectious Diseases , Volume 21 , Issue 1, 2021 December , {Pages 13-Jan }

Abstract

Campylobacter jejuni (C. jejuni) is a leading cause of acute gastroenteritis in human worldwide. The aim of study was to assess the distribution of sialylated lipooligosaccharide (LOS) classes and capsular genotypes in C. jejuni isolated from Iranian children with gastroenteritis. Furthermore, the level of dnaK gene expression in C. jejuni strains with selected capsular genotypes and LOS classes was intended. Moreover, a comprehensive study of C. jejuni MLST-genotypes and inclusive comparison with peer sequences worldwide was intended. Twenty clinical C. jejuni strains were isolated from fecal specimens of 280 children aged 0–5 years, suspected of bacterial gastroenteritis, which admitted to 3 children hospitals from May to October, 201

Prevalence of Antibiotic Resistance in Vibrio cholerae: A Meta-analysis

Sareh Bagheri-Josheghani, Bita Bakhshi, Maryam Mousavi
Journal Paper , 2021 February 11, {Pages }

Abstract

Background: Cholera could cause severe watery diarrhea and even death, but in patients diagnosed with severe dehydration, treatment with an appropriate antimicrobial agent could decrease the volume of diarrhea and shorten the duration of V. cholerae shedding. Unfortunately, due to the high antibiotic’s consumption, antibiotic resistance in V. cholerae strains is progressively increasing worldwide. The present systematic review and meta-analysis study aimed to investigate the incidence of antibiotic resistance in V. cholerae strains worldwide.Methods: The incidence of antibiotic resistance in V. cholerae strains was assessed by conducting a systematic review and searching international databases including PubMed and Google Scholar for arti

Prevalence of intestinal parasitic infections and Campylobacter spp. among children with gastrointestinal disorders in Tehran, Iran

Mohammad Barati, Ali Taghipour, Bita Bakhshi, Saeed Shams, Majid Pirestani
Journal PaperParasite Epidemiology and Control , 2021 February 14, {Pages e00207 }

Abstract

Co-infection of intestinal parasitic infections (IPIs) and Campylobacter spp. are public health problem in both developing and developed countries. This study was conducted to determine prevalence of IPIs and Campylobacter spp. among children with gastrointestinal disorders in Tehran. In this descriptive cross-sectional survey, 283 fresh stool samples were collected from all individuals and examined by standard parasitological methods including direct slide smear, formalin-ether concentration, trichrome staining, modified Ziehl-Neelsen staining, and chromotrope 2R staining techniques were used for detection of intestinal protozoa and helminths. Furthermore, culture and multiplex-PCR were also used to identify the species of Campylobacter. D

Fabrication, tuning and performance analysis of polyacrylonitrile (PAN)-derived microfiltration membranes for bacteria removal from drinking water

Seyed Saeid Hosseini, Hadi Khodadadi, Bita Bakhshi
Journal PaperKorean Journal of Chemical Engineering , Volume 38 , Issue 1, 2021 January , {Pages 32-45 }

Abstract

Removal of bacterial contaminations from water using advanced technologies is one of the essential steps in improving human health. The present study’s aim was to develop high performance microfiltration membranes from polyacrylonitrile (PAN) for bacteria removal from drinking water. The characteristics and performance of membranes were tuned through exploring the variation of prominent fabrication and operating parameters. The findings reveal that increasing PAN concentration in dope and addition of citric acid were successful in tailoring membrane microstructure. Bacteria rejection in modified membranes improved by exhibiting high log removal values (LRV) ranging from 3.92 (99.87%) to 5.57 (99.99%) while permeate fluxes w

Clonal diversity and genomic characterization of Panton-valentine Leukocidin (PVL)-positive Staphylococcus aureus in Tehran, Iran

Shahin Najar-Peerayeh, Abbas Yadegar, Bita Bakhshi
Journal PaperBMC infectious diseases , Volume 21 , Issue 1, 2021 December , {Pages 12-Jan }

Abstract

Some Staphylococcus aureus strains produce Panton-Valentine leukocidin (PVL), a bi-component pore-forming toxin, which causes leukocyte lysis and tissue necrosis. Currently, there is very limited information on the molecular epidemiology of PVL-encoding S. aureus strains in Iran. This study aimed to determine the molecular epidemiology and genetic background of PVL-positive S. aureus clinical strains isolated from Iranian patients. A total of 28 PVL-positive S. aureus strains were detected from 600 S. aureus isolates between February 2015 and March 2018 from different hospitals in Tehran, Iran. Antimicrobial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Molecular genot

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Nafiseh Baheiraei, Hossein Eyni, Bita Bakhshi, Raziyeh Najafloo, Navid Rabiee
Journal PaperScientific Reports , Volume 11 , Issue 1, 2021 April 22, {Pages 09-Jan }

Abstract

Bioactive glasses (BGs) have attracted added attention in the structure of the scaffolds for bone repair applications. Different metal ions could be doped in BGs to induce specific biological responses. Among these ions, strontium (Sr) is considered as an effective and safe doping element with promising effects on bone formation and regeneration. In this experiment, we evaluated the antibacterial activities of the gelatin-BG (Gel-BG) and Gel-BG/Sr scaffolds in vitro. The osteogenic properties of the prepared scaffolds were also assessed in rabbit calvarial bone defects for 12 weeks. Both scaffolds showed in vivo bone formation during 12 weeks with the newly formed bone area in Gel-BG/Sr scaffold was higher than that in Gel-BG scaffolds afte

Vibrio cholerae toxin co‐regulated pilus provokes inflammatory responses in co‐culture model of Caco‐2 and Peripheral Blood Mononuclear Cells (PBMC) leading?…

Maryam Ghasemi, Bita Bakhshi, Reza Khashei, Sara Soudi, Mina Boustanshenas
Journal PaperMicrobiology and Immunology , 2021 April 29, {Pages }

Abstract

The aim of this study was to assess the modulatory effect of TcpA in the expression of CEACAM1 adhesin molecule and IL‐1, IL‐8 and TNFα pro‐inflammatiory cytokines in the co‐culture model of Caco‐2/PBMC that can mimic the intestinal milieu. The tcpA gene from V.cholerae ATCC14035 was cloned in pET‐28a and transformed into E.coli Bl‐21. The recombinant TcpA‐His6 protein was expressed and purified using the Ni‐column chromatography. The sequencing of transformed plasmid and Western blotting of purified protein confirmed the identity of rTcp. Cytotoxicity of different concentrations of recombinant protein for human colon carcinoma cell line (Caco‐2 cell) was assessed by MTT assay and showed viability of 92%, 82% and 70 %,

Immunomodulatory effects of mesenchymal stem cell-conditioned media on lipopolysaccharide of Vibrio cholerae as a vaccine candidate

M Bahroudi, B Bakhshi, S Soudi, S Najar-Peerayeh
Journal Paper , , {Pages }

Abstract

Methicillin-resistant Staphylococcus aureus colonization of infectious and non-infectious skin and soft tissue lesions in patients in Tehran

H Khalili, S Najar-Peerayeh, M Mahrooghi, P Mansouri, B Bakhshi
Journal Paper , , {Pages }

Abstract

Investigating the effect of an identified mutation within a critical site of PAS domain of WalK protein in a vancomycin-intermediate resistant Staphylococcus aureus by …

N Baseri, S Najar-Peerayeh, B Bakhshi
Journal Paper , , {Pages }

Abstract

Significant contribution of the CmeABC Efflux pump in high-level resistance to ciprofloxacin and tetracycline in Campylobacter jejuni and Campylobacter coli clinical isolates

S Sharifi, B Bakhshi, S Najar-Peerayeh
Journal Paper , , {Pages }

Abstract

Transcriptome analysis of biofilm formation under aerobic and microaerobic conditions in clinical isolates of Campylobacter spp.

E Ohadi, B Bakhshi, BS Kalani, M Talebi, G Irajian
Journal Paper , , {Pages }

Abstract

Home-based exercise training influences gut bacterial levels in multiple sclerosis

M Mokhtarzade, MM Shamsi, M Abolhasani, B Bakhshi, MA Sahraian, ...
Journal Paper , , {Pages }

Abstract

Dual-responsive nisin loaded chondroitin sulfate nanogel for treatment of bacterial infection in soft tissues

M Tayeferad, S Boddohi, B Bakhshi
Journal Paper , , {Pages }

Abstract

Immunomodulatory Effects of Adipose-derived Mesenchymal Stem Cells on Epithelial Cells Function in Response to Vibrio cholera in a Co-culture Model.

A Moulazadeh, S Soudi, B Bakhshi
Journal Paper , , {Pages }

Abstract

Effect of bacteria on self-healing of bio-concrete by increasing compressive strength

A Noori Shahrabadi, A Hassani, B Bakhshi
Journal Paper , , {Pages }

Abstract

Vibrio cholerae toxin coregulated pilus provokes inflammatory responses in Coculture model of Caco‐2 and peripheral blood mononuclear cells (PBMC) leading to …

M Ghasemi, B Bakhshi, R Khashei, S Soudi, M Boustanshenas
Journal Paper , , {Pages }

Abstract

High prevalence of Campylobacter jejuni CC21 and CC257 clonal complexes in children with gastroenteritis in Tehran, Iran

M Sarhangi, B Bakhshi, SN Peeraeyeh
Journal Paper , , {Pages }

Abstract

The effect of subinhibitory concentration of chlorhexidine on the evolution of vancomycin-intermediate Staphylococcus aureus and the induction of mutations in walKR and vraTSR …

N Baseri, S Najar-Peerayeh, B Bakhshi
Journal Paper , , {Pages }

Abstract

Isolation and Kinetic Modeling of New Culture from Compost with High Capability of Degrading n-Hexadecane, Focused on Ochrobactrum Oryzae and Paenibacillus Lautus

Mohammad Reza Samaei, Mahrokh Jalili, Fariba Abbasi, Sayed Bagher Mortazavi, Ahmad Jonidi Jafari, Bita Bakhshi
Journal PaperSoil and Sediment Contamination: An International Journal , 2020 February 2, {Pages 13-Jan }

Abstract

Nowadays, petroleum pollution is one of the most important environmental challenges in Iran. Some bacteria were isolated for hexadecane degrading from soil, sediment, and sludge; however, there is no report on its isolation from compost. This study was aimed to isolation, molecular identification of novel bacteria with high capability of hexadecane-degrading from compost using enrichments media. The isolated bacteria were identified by PCR with 16S rDNA method and were studied their ability for removing hexadecane in liquid and solid medium. According to results, the isolated bacteria were identified as O.oryzae and P.lautus. In liquid medium, hexadecane concentration decreased from 3000?1.4 to 366.96?0.9 mg/l (87.77?0.2%) by O.oryzae, whil

Current Teaching

  • MS.c.

    Diagnostic bacteriology II

  • Ph.D.

    Advanced Bacterial Genetics

  • Ph.D.

    Advanced Bacterial Genetics

  • Ph.D.

    Bioinformatics

  • Ph.D.

    Bioinformatics

Teaching History

  • Ph.D.

    Bacterial Toxins

  • MS.c.

    Cellular and Molecular Biology (Pro/Eu)

  • MS.c.

    Clinical Bacteriology I

  • Ph.D.

    Laboratory Diagnostics of Fastidious and Anaerobic Bacteria

  • MS.c.

    Microbiology

  • MS.c.

    Molecular Detection of Bacteriology

  • 2021
    Asadi, Sepehr
    Investigation of genetic relatedness of Vibrio cholerae isolates from Iran 2022 outbreaks with cholera 7th pandemic
  • 2017
    Shahbazi, Tayebe
    Determination of dominant gastrointestinal microbiota of patients with Colorectal Cancer (CRC) by 16S rRNA metagenomic method and evaluation of the effect of their colon content supernatant on CRC related genes expression in Caco2 cell line
  • 2019
    Heidari, Leila
  • 2019
    Derakhshansefidi, Mozhgan
  • 2021
    Goodarzi, Forough

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