Fa
  • Ph.D. (2014)

    Tissue Engineering

    School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

  • M.Sc. (2010)

    Medical Engineering - Biomaterials

    , Amirkabir University of Technology, Tehran, Iran

  • B.Sc. (1999)

    , Shahid Beheshti University of Medical Sciences & Health Services, Tehran, Iran

  • Synthesis and characterization of orthopedics grafts using tissue engineering for bone repair
  • Cardiac tissue engineering constructing electroactive cardiac patches/ cardiac cell therapy
  • Synthesis of antibacterial structures based on graphene oxide and reduced graphene oxide
  • Tissue Engineering laboratory

    Research field: Freeze dryer-Electrospinning-Furnace

    Expert: Ms. Mirzaee

    Phone: 02182884853

    Address: Jalal Al-Ahmad highway, Tarbiat Modares university, faculty of medical sciences, 1st floor

Dr. Nafiseh Baheiraei is a nationally recognised expert in Tissue Engineering. She completed her PhD in Tissue Engineering at Tehran University of Medical Sciences, Iran. She works as an associate Professor at Faculty of Medical Sciences, Tarbiat Modares University, Iran. Her current research interests are antibacterial materials, bone and cardiac tissue engineering. In recent years, she has focused on better techniques for fabricating novel scaffolds containing electroactive moieties including graphene-based nanomaterials. Dr. Baheiraeis expertise in Tissue Engineering has been recognised by a range of awards and patents at both national and international levels.

Contact

Curriculum Vitae (CV)

Reduced graphene oxide facilitates biocompatibility of alginate for cardiac repair (vol 35, pg 363, 2020)

Karimi N Hajishoreh, N Baheiraei, N Naderi, M Salehnia
Journal PaperJOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS , Volume 36 , Issue 1, 2021 January 1, {Pages 90-90 }

Abstract

Human Mesenchymal Stem Cells being Encapsulated in Alginate/reduced Geraphen Oxide Improving Infarct Expansion, and Inducing Neovasculariziation Formation in Ischemic Myocardium

Nafiseh Baheiraei, Nasim Naderi, Mojdeh Salehnia, Behshid Ghadrdoost, Mehdi Razavi
Journal Paper , 2021 February 5, {Pages }

Abstract

Currently, one of the new therapeutic strategies is injection of hydrogel and cells to myocardial infarction (MI) patients, which has some limitations such as lack of electromechanical properties and neovascularization. In this study, we investigated the therapeutic potential of new electroactive hydrogel [Reduced graphene oxide (rGO)/Alginate (ALG)] encapsulated human bone marrow mesenchymal stem cell (BMSC) in different experimental groups. The study was done in rat model of chronic ischemic cardiomyopathy by ligating the left anterior descending coronary artery (LAD). Echocardiograms were analyzed at 4 and 8 weeks after MI induction.Experimental groups particularly (BMSC) encapsulated in rGO-ALG increased signi cantly improvement of frac

Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite

Navid Rabiee, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri, Yousef Fatahi, Nafiseh Baheiraei, Moein Safarkhani, Abdullah Aldhaher, Rassoul Dinarvand
Journal PaperScientific reports , Volume 11 , Issue 1, 2021 March 23, {Pages 15-Jan }

Abstract

Herein, in a one-pot method, the reduced graphene oxide layers with the assistance of multiwalled carbon nanotubes were decorated to provide a suitable space for the in situ growth of CoNi 2 S 4, and the porphyrins were incorporated into the layers as well to increase the sensitivity of the prepared nanostructure. The prepared nanocomposite can establish π–π interactions between the genetic material and on the surface of porphyrin rings. Also, hydrogen bonds between genetic domains and the porphyrin’nitrogen and the surface hydroxyl groups are probable. Furthermore, the potential donor–acceptor relationship between the d 7 transition metal, cobalt, and the genetic material provides a suitable way to increase the interaction and gene

Biohybrid oxidized alginate/myocardial extracellular matrix injectable hydrogels with improved electromechanical properties for cardiac tissue engineering

Ali Mousavi, Shohreh Mashayekhan, Nafiseh Baheiraei, Ali Pourjavadi
Journal PaperInternational Journal of Biological Macromolecules , 2021 March 19, {Pages }

Abstract

Injectable hydrogels which mimic the physicochemical and electromechanical properties of cardiac tissue is advantageous for cardiac tissue engineering. Here, a newly-developed in situ forming double-network hydrogel derived from biological macromolecules (oxidized alginate (OA) and myocardial extracellular matrix (ECM)) with improved mechanical properties and electrical conductivity was optimized. 3-(2-aminoethyl amino) propyltrimethoxysilane (APTMS)-functionalized reduced graphene oxide (Amine-rGO) was added to this system with varied concentrations to promote electromechanical properties of the hydrogel. Alginate was partially oxidized with an oxidation degree of 5% and the resulting OA was cross-linked via calcium ions which was reacted

Graphene Coated Scaffold for Bone Tissue Engineering: Physicochemical and Osteogenic Characterizations

Sajad Bahrami, Nafiseh Baheiraei, Mostafa Shahrezaee
Journal Paper , 2021 April 15, {Pages }

Abstract

Variety of bone-related diseases and injures and limitations of traditional regeneration methods need to introduce new tissue substitutes. Tissue engineering and regeneration combined with nanomedicine can provide different natural or synthetic and combined scaffolds with bone mimicking properties for implant in the injured area. In this study, we synthesized collagen (Col) and reduced graphene oxide coated collagen (Col-rGO) scaffolds and evaluated their in vitro and in vivo effects on bone tissue repair. Col and Col-rGO scaffolds were synthesized by chemical crosslinking and freeze-drying methods. The surface topography, mechanical and chemical properties of scaffolds were characterized and showed threedimensional (3D) porous scaffolds an

Biomimetic reduced graphene oxide coated collagen scaffold for in situ bone regeneration

S Bahrami, N Baheiraei, M Shahrezaee
Journal Paper , , {Pages }

Abstract

Effects of Kartogenin/PLGA Nanoparticles on Silk Scaffold Properties and Stem Cell Fate

MR Nia, F Bagheri, N Baheiraei
Journal Paper , , {Pages }

Abstract

Trehalose Attenuates Detrimental Effects of Freeze-Drying on Human Sperm Parameters

IH Elaheh Shahmoradi , Nafiseh Baheiraei
Journal Paper , , {Pages }

Abstract

Reduced graphene oxide facilitates biocompatibility of alginate for cardiac repair (vol 35, pg 363, 2020)

KN Hajishoreh, N Baheiraei, N Naderi, M Salehnia
Journal Paper , , {Pages }

Abstract

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

NR Nafiseh Baheiraei, Hossein Eyni, Bita Bakhshi, Raziyeh Najafloo
Journal Paper , , {Pages }

Abstract

Nanobiomaterials in musculoskeletal regeneration

Nafiseh Baheiraei Sara Tabatabaee, Mohammed Najafi-Ashtiani, Ali Mousavi
Journal Paper , 2020 January , {Pages }

Abstract

Stimulus-responsive sequential release systems for drug and gene delivery

Journal PaperNano Today , Volume 34 , 2020 January , {Pages }

Abstract

Conductive biomaterials as nerve conduits: Recent advances and future challenges

Payam Zarrintaj, Ehsan Zangene, Saeed Manouchehri, Leila Mohammadi Amirabad, Nafiseh Baheiraei, Mahmoud Reza Hadjighasem, Mehdi Farokhi, Mohammad Reza Ganjali, Brian W Walker, Mohammad Reza Saeb, Masoud Mozafari, Sabu Thomas, Nasim Annabi
Journal Paper , Volume 20 , 2020 September 1, {Pages 100784 }

Abstract

Millions of people around the world are in distress due to neurodegenerative disorders. There have been continued attempts to design biomaterial-based therapies for the regeneration of dysfunctional neural tissues, mainly damaged peripheral nerve and spinal cord. The development of nerve guidance channels, where the distal and proximal end of a damaged nerve is sutured to an artificial conduit, has been one main strategy to treat damaged nerves. Different types of biomaterials have been utilized for fabricating the functional nerve conduits with the capability to stimulate the cellular function. Due to their intrinsic electrical properties, conductive materials revealed promising features for promoting regeneration of peripheral nerve injur

Reduced graphene oxide facilitates biocompatibility of alginate for cardiac repair

Negar Karimi Hajishoreh, Nafiseh Baheiraei, Nasim Naderi, Mojdeh Salehnia
Journal PaperJournal of Bioactive and Compatible Polymers , Volume 35 , Issue 05-Apr, 2020 July , {Pages 363-377 }

Abstract

The benefits of combined cell/material therapy appear promising for myocardial infarction treatment. The safety of alginate, along with its excellent biocompatibility and biodegradability, has been extensively investigated for cardiac tissue engineering. Among graphene-based nanomaterials, reduced graphene oxide has been considered as a promising candidate for cardiac treatment due to its unique physicochemical properties. In this study, the reduced graphene oxide incorporation effect within alginate hydrogels was investigated for cardiac repair application. Reduced graphene oxide reinforced alginate properties, resulting in an increase in gel stiffness. The cytocompatibility of the hydrogels prepared with human bone marrow–derived mesenc

Conversion of Neural Stem Cells into Functional Neuron-Like Cells by MicroRNA-218: Differential Expression of Functionality Genes

Wissam Khalil, Taki Tiraihi, Masoud Soleimani, Nafiseh Baheiraei, Kazem Zibara
Journal PaperNeurotoxicity Research , Volume 38 , Issue 3, 2020 October , {Pages 707-722 }

Abstract

Conversion of mesenchymal stem cells (MSC) into neuron-like cells (NLC) is a feasible cell therapy strategy for replacing lost neurons in neuronal disorders. In this study, adipose-derived MSC (ADMSC) were converted into neural stem cells (NSC) via neurosphere. The resulting NSC were then differentiated into NLC by transduction with microRNA-218, using a lentiviral vector. ADMSC, NSC, and NLC were first characterized by flow cytometry, RT-PCR, and immunocytochemistry. The functionality of the NLC was evaluated by qRT-PCR and patch clamp recording. Immunophenotyping of ADMSC showed their immunoreactivity to MSC markers CD90, CD73, CD105, and CD49d, but not to CD31 and CD45. RT-PCR results demonstrated the expression of nestin, neurogenin, ne

Stimulus-responsive sequential release systems for drug and gene delivery

Sepideh Ahmadi, Navid Rabiee, Mojtaba Bagherzadeh, Faranak Elmi, Yousef Fatahi, Fatemeh Farjadian, Nafiseh Baheiraei, Behzad Nasseri, Mohammad Rabiee, Niloufar Tavakoli Dastjerd, Ali Valibeik, Mahdi Karimi, Michael R Hamblin
Journal Paper , Volume 34 , 2020 October 1, {Pages 100914 }

Abstract

In recent years, a range of studies have been conducted with the aim to design and characterize delivery systems that are able to release multiple therapeutic agents in controlled and programmed temporal sequences, or with spatial resolution inside the body. This sequential release occurs in response to different stimuli, including changes in pH, redox potential, enzyme activity, temperature gradients, light irradiation, and by applying external magnetic and electrical fields. Sequential release (SR)-based delivery systems, are often based on a range of different micro- or nanocarriers and may offer a silver bullet in the battle against various diseases, such as cancer. Their distinctive characteristic is the ability to release one or more

Controlled Gene Delivery Systems: Nanomaterials and Chemical Approaches

Sepideh Ahmadi, Navid Rabiee, Yousef Fatahi, Mojtaba Bagherzadeh, Meysam Gachpazan, Nafiseh Baheiraei, Behzad Nasseri, Mahdi Karimi, Thomas J Webster, Michael R Hamblin
Journal Paper , Volume 16 , Issue 5, 2020 May 1, {Pages 553-582 }

Abstract

Successful gene therapy depends on the design of effective gene delivery systems. A gene delivery system is considered a powerful tool for the release of genetic material within cells resulting in a change in cell functions and protein production. The release of genes in a controlled manner by using appropriate carriers facilitates their release without side effects and increases the expression of genes at the released site. It is expected that significant changes in the combination of several genes and drugs can be provided by developing treatment systems sensitive to different stimuli such as redox potential, pH variations, temperature gradients, light irradiation, and enzyme activity. The most important advantages for the release of gene

Microfluidic devices in tissue engineering

Sajad Bahrami, Nafiseh Baheiraei, Mohammed Najafi-Ashtiani, Shirin Nour, Mehdi Razavi
Journal Paper , 2020 December 15, {Pages 209-233 }

Abstract

Microfluidics deals with the manipulation of small fluid volumes within a system of microchannels. Microfluidic devices are widely used in biological sciences, and specifically in tissue engineering to either repair or replace damaged cells, tissues or organs. Indeed, microfluidic systems can provide opportunities for various tissue engineering applications, such as cell culture, scaffold synthesis, drug screening, point-of-care detection, and fabrication of therapeutic devices in a rapid, precise, and high-throughput manner. With regard to tissue engineering, this technology has several advantages compared with traditional 2D and 3D cell culture methods, including spatiotemporal controllability, control over fluid and gas flow, physiologic

Synthesis and characterization of collagen/calcium phosphate scaffolds incorporating antibacterial agent for bone tissue engineering application

Raziyeh Najafloo, Nafiseh Baheiraei, Rana Imani
Journal PaperJournal of Bioactive and Compatible Polymers , 2020 November 6, {Pages 0883911520966692 }

Abstract

In the present study, we developed a novel niosomal nanocarrier embedded into a collagen/β- tricalcium phosphate (Col/β-TCP) scaffold for the local delivery of thymol as a natural anti-bacterial reagent. The niosomal Col/β-TCP (N-Col/β-TCP) scaffolds with different weight ratios of β-TCP to Col were prepared by freeze-drying. The antimicrobial activities of the prepared samples against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were assessed by agar diffusion method. The release profile of niosomal thymol from the optimized composite scaffolds showed a sustained profile where 66% of the loaded thymol was released over 30 days. The compressive modulus of niosome added scaffolds with an equal ratio of β-TCP an

Multifunctional Conductive Biomaterials as Promising Platforms for Cardiac Tissue Engineering

Ali Mousavi, Sadaf Vahdat, Nafiseh Baheiraei, Mehdi Razavi, Mohammad Hadi Norahan, Hossein Baharvand
Journal Paper , 2020 December 14, {Pages }

Abstract

Adult cardiomyocytes are terminally differentiated cells that result in minimal intrinsic potential for the heart to self-regenerate. The introduction of novel approaches in cardiac tissue engineering aims to repair damages from cardiovascular diseases. Recently, conductive biomaterials such as carbon- and gold-based nanomaterials, conductive polymers, and ceramics that have outstanding electrical conductivity, acceptable mechanical properties, and promoted cell–cell signaling transduction have attracted attention for use in cardiac tissue engineering. Nevertheless, comprehensive classification of conductive biomaterials from the perspective of cardiac cell function is a subject for discussion. In the present review, we classify and summa

Current Teaching

  • MS.c.

    Bioreactors in Biomedical Engineering

  • MS.c.

    Adult Stem Cells and Tissue Homeostasis

  • Ph.D.

    Principles of Materials

  • Ph.D.

    Two and Three Dimensional Cell Culture

  • Ph.D.

    Two and Three Dimensional Cell Culture

Teaching History

  • MS.c.

    Biomaterials

  • MS.c.

    Fundamentals of Regenerative Medicine

  • Ph.D.

    Principles of Tissue Development & Repair

  • MS.c.

    Stem cells and tissue regeneration

  • MS.c.

    The Principles of Commercialization and Standardization of Biomedical Engineering Products

  • 2021
    Pourebrahim, Fatemeh
    Design and fabrication of electrospun scaffold based on gelatin containing calcium phosphate nanoparticles: in vitro and in vivo study
  • 2020
    Edrisi, Fatemeh
  • 2021
    Shams, Fatemeh
  • 2021
    Safaee, Maryam
  • 2020
    Ramezani, Mina
    Evaluation of cardiac function following intramyocardial injection of alginate and extracted crocin along with bone marrow derived mesenchymal stem cells in rat model of myocardial infarction
  • 2021
    Keramati, Bahman
  • Award winner of Annual Student Writers Contest for writing the book entitled "an Introduction on characterization methods in tissue engineering",2013, Tehran, Iran.
  • Award winner on best innovation on medical sciences, International Congress of Prof. Yalda , Oct.2016, Tehran, Iran
  • Award winner on best poster prize, International Congress of Prof. Yalda Oct.2014, Tehran, Iran
  • Award winner on best poster prize, Royan International 12th Congress on Stem Cells Biology & Technology. Sept. 2016, Tehran, Iran.
  • Award winner on best poster prize, Royan International 16th Congress on Stem Cells Biology & Technology. Sept. 2020, Tehran, Iran
  • Award winner on invention, Faculty of Medical Sciences, Tarbiat Modares University Dec.2017, Tehran, Iran
  • Award winner on invention, Faculty of Medical Sciences, Tarbiat Modares University .2018, Tehran, Iran
  • Award winner on second Avicenna Festival, Tehran University of Medical Sciences, Dec 2015, Tehran, Iran
  • Award winner on selected researcher, Faculty of Medical Sciences, Tarbiat Modares University Dec.2022, Tehran, Iran
  • Award winner on selected researcher, Faculty of Medical Sciences, Tarbiat Modares University Dec.2023, Tehran, Iran
  • Dr Kazemi Ashtiani Award winner received by Iranian National Elite Organization, Sept. 2016, Tehran, Iran
  • First rank postgraduate student (MSc degree), Cumulative GPA: 19.48/20, 2010
  • First rank postgraduate student (PhD degree), Cumulative GPA: 19.75/20, 2014
  • Honored Ph.D. graduated student, school of advanced technology, Tehran University of Medical Sciences, June 2015
  • Selected research section in the field of medical sciences,Modares Women Event,2021
  • Deputy Director of Applied Research and Technology office, Tarbiat Modares University, Dec. 2020-May 2022
  • Eitorial board of Journal of Pathobiology Research,2017-present
  • Vice Dean of tissue engineering affairs, Faculty of medical sciences, Tarbiat Modares University, Tehran, Iran,Dec.2017-2019
  • Collaboration in strategic transformation plan, vice dean of research, Tarbiat Modares University, Tehran, Iran,Oct.2017-Present .
  • Member of scientific committee and chairperson of many national congresses on tissue engineering and regenerative medicine,Iran,2013-present.
  • Eitorial board of Journal of Applied Tissue Engineering,2017-2019

Top

New

    no record found