Background: Synchronization between the embryonic stage and the uterine endometrial lining is important in the outcomes of the vitrified-warmed embryo transfer (ET) cycles.Objective: The aim was to investigate the effect of the exact synchronization between the cleavage stage of embryos and the duration of progesterone administration on the improvement of clinical outcomes in frozen embryo transfer (FET) cycles.Materials and Methods: 312 FET cycles were categorized into two groups:(A) day-3 ET after three days of progesterone administration (n= 177) and (B) day-2 or-4 ET after three days of progesterone administration (n= 135). Group B was further divided into two subgroups: B1: day-2 ET cycles, that the stage of embryos were less than the

Objective: The aim of this study was to screen the potential of human embryos to develop into expanding blastocysts following in vitro embryo splitting and then assess the quality of the generated blastocysts based on chromosomal characteristics and using morphokinetics.Materials and Methods: In this experimental study, a total of 82 good quality cleavage-stage donated embryos (8-14 cells) were used (24 embryos were cultured to the blastocyst stage as controls and 58 embryos underwent in vitro splitting). After in vitro splitting, the blastomere donor and blastomere recipient embryos were named twin A and twin B, respectively. Morphokinetics and morphological parameters were evaluated using a time-lapse system in the blastocysts developed f

To investigate the impact of antioxidants in sperm parameters and reduction in reactive oxygen species production during the freeze‐thaw process. PubMed, Scopus, Web of Science, Embase and Cochrane central library were systematically searched. Of the 1583 articles, 23 studies were selected for data extraction. Our results show that antioxidants improved sperm progressive motility (standardised mean difference (SMD)?=?1; 95% CI: 0.62, 1.38; p?

Aims: The present study aims to compare the survival rate, reconstitution and dislocation of meiotic spindle of mouse oocyte vitrification between open and close systems.Materials & Methods: 131 matured oocytes (containing meiotic spindle) harvested from 6-8 week-old BALB/C and divided into two groups of open and close systems. After exposure of oocytes in vitrification media, oocytes were loaded on cryotop in open group and on Rapid-i in close group, and then vitrified. After warming, oocytes were incubated for 3 hours and evaluated for survival rate, presence and location of re-polymerized meiotic spindle by PolScope system.Findings: Survival rate was significantly higher in open system compared to close system (91.1% vs 68.6%, respective

A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low-and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4%(62.3 (55.1–70.8) million) to 6.4%(58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of< 5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2%(30 (22.8–38.5) million) in 2000 to 6.0%(55.5 (44.8–67.9) million

BackgroundRigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease.MethodsGBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and t

BackgroundAccurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019.Methods8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-

BackgroundIn an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries.MethodsGBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territo